This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
3G11 Sialoganglioside Antigen Monoclonal Antibody (eBio3G11 (SM3G11, 3G11)), eFluor 660, eBioscience
catalog :
50-5443-82
quantity :
100 ug
price :
US 370.00
clonality :
monoclonal
host :
mouse
conjugate :
efluor 660
clone name :
eBio3G11 (SM3G11, 3G11)
reactivity :
mouse, rat
application :
flow cytometry
citations: 4
Reference
Zhao Z, Ciric B, Yu S, Li H, Yang J, Kamoun M, et al. Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency. J Neurol Sci. 2010;295:66-74 pubmed publisher
Zhang G, Yu S, Calida D, Zhao Z, Gran B, Kamoun M, et al. Loss of the surface antigen 3G11 characterizes a distinct population of anergic/regulatory T cells in experimental autoimmune encephalomyelitis. J Immunol. 2006;176:3366-73 pubmed
Hayakawa K, Hardy R. Murine CD4+ T cell subsets defined. J Exp Med. 1988;168:1825-38 pubmed
Ernst D, Hobbs M, Torbett B, Glasebrook A, Rehse M, Bottomly K, et al. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol. 1990;145:1295-302 pubmed
product information
Product Type :
Antibody
Product Name :
3G11 Sialoganglioside Antigen Monoclonal Antibody (eBio3G11 (SM3G11, 3G11)), eFluor 660, eBioscience
Catalog # :
50-5443-82
Quantity :
100 ug
Price :
US 370.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse, Rat
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse, Rat
Clone :
eBio3G11 (SM3G11, 3G11)
Isotype :
IgM, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
The 3G11 sialylated carbohydrate antigen was found to be expressed by thymoyctes and peripheral T cells, but not by B cells, myeloid cells or erythrocytes. 3G11 is expressed at higher levels on CD4+ T cells than on CD8+ T cells, however expression on both of these subsets decreases with advancing age. In thymus, 3G11 is expressed on approximately 20% of total thymocytes. 3G11 has also been used as a marker to distinguish naive and memory T cells, as 3G11 is irreversibly down-regulated upon activation of CD4+ T cells. 3G11 antibodies can be used to block binding of antibodies to CD3 epsilon, suggesting close proximity of these two proteins. Recently, it has been demonstrated that loss of 3G11 expression in experimental autoimmune encephalomyelitis (EAE) is associated with an anergic, regulatory T phenotype. Purified 3G11- T cells were able to suppress proliferation and cytokine production of 3G11+ T cells, and part of this effect was due to the secretion of IL-10.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
3G11 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA