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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
EOMES Monoclonal Antibody (WD1928), eFluor™ 660, eBioscience
catalog :
50-4877-41
quantity :
25 Tests
price :
US 193.00
clonality :
monoclonal
host :
mouse
conjugate :
efluor 660
clone name :
WD1928
reactivity :
human, pigs
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 42
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 6a-6d
Bhattacharya P, Ellegård R, Khalid M, Svanberg C, Govender M, Keita A, et al. Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells. elife. 2020;9: pubmed publisher
  • flow cytometry; human; loading ...; fig 3c
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
  • flow cytometry; human; loading ...; fig 5a
Demers K, Makedonas G, Buggert M, Eller M, Ratcliffe S, Goonetilleke N, et al. Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection. PLoS Pathog. 2016;12:e1005805 pubmed publisher
  • flow cytometry; human; loading ...; fig 4a
Thomsen E, Mich J, Yao Z, Hodge R, Doyle A, Jang S, et al. Fixed single-cell transcriptomic characterization of human radial glial diversity. Nat Methods. 2016;13:87-93 pubmed publisher
  • flow cytometry; human; loading ...; fig 4e
Simonetta F, Pradier A, Bosshard C, Masouridi Levrat S, Chalandon Y, Roosnek E. NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin. J Immunol. 2015;195:4712-20 pubmed publisher
  • flow cytometry; human; fig 1
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
  • flow cytometry; human; fig 5
Srivastava R, Khan A, Spencer D, Vahed H, Lopes P, Thai N, et al. HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgenic. J Immunol. 2015;194:2232-48 pubmed publisher
  • flow cytometry; human; fig 3
Khan A, Srivastava R, Spencer D, Garg S, Fremgen D, Vahed H, et al. Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes. J Virol. 2015;89:3776-92 pubmed publisher
Kourtis N, Wang Q, Wang B, Oswald E, Adler C, Cherravuru S, et al. A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. Nat Cancer. 2022;3:885-898 pubmed publisher
McMurray J, von Borstel A, Taher T, Syrimi E, Taylor G, Sharif M, et al. Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program. Cell Rep. 2022;39:110858 pubmed publisher
Lutter L, Roosenboom B, Brand E, Ter Linde J, Oldenburg B, Van Lochem E, et al. Homeostatic Function and Inflammatory Activation of Ileal CD8+ Tissue-Resident T Cells Is Dependent on Mucosal Location. Cell Mol Gastroenterol Hepatol. 2021;12:1567-1581 pubmed publisher
Méndez Lagares G, Chin N, Chang W, Lee J, Rosás Umbert M, Kieu H, et al. Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function. J Clin Invest. 2021;131: pubmed publisher
Sia W, Hey Y, Foo R, Wang L, Leeansyah E. Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells. STAR Protoc. 2021;2:100487 pubmed publisher
Hou Q, Xiao Q, Sun X, Ju X, Luo Z. TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a. Sci Adv. 2021;7: pubmed publisher
Pattekar A, Mayer L, Lau C, Liu C, Palko O, Bewtra M, et al. Norovirus-Specific CD8+ T Cell Responses in Human Blood and Tissues. Cell Mol Gastroenterol Hepatol. 2021;11:1267-1289 pubmed publisher
Buggert M, Vella L, Nguyen S, Wu V, Chen Z, Sekine T, et al. The Identity of Human Tissue-Emigrant CD8+ T Cells. Cell. 2020;183:1946-1961.e15 pubmed publisher
Song M, Pebworth M, Yang X, Abnousi A, Fan C, Wen J, et al. Cell-type-specific 3D epigenomes in the developing human cortex. Nature. 2020;587:644-649 pubmed publisher
Tao L, Farooq M, Gao Y, Zhang L, Niu C, Ajmal I, et al. CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells. Cancers (Basel). 2020;12: pubmed publisher
Papagno L, Kuse N, Lissina A, Gostick E, Price D, Appay V, et al. The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro. Sci Rep. 2020;10:11620 pubmed publisher
Yoshida T, Ichikawa J, Giuroiu I, Laino A, Hao Y, Krogsgaard M, et al. C reactive protein impairs adaptive immunity in immune cells of patients with melanoma. J Immunother Cancer. 2020;8: pubmed publisher
Katsuyama E, Suárez Fueyo A, Bradley S, Mizui M, Marin A, Mulki L, et al. The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections. Cell Rep. 2020;30:112-123.e4 pubmed publisher
Marquardt N, Kekäläinen E, Chen P, Lourda M, Wilson J, Scharenberg M, et al. Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells. Nat Commun. 2019;10:3841 pubmed publisher
Sagebiel A, Steinert F, Lunemann S, Korner C, Schreurs R, Altfeld M, et al. Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine. Nat Commun. 2019;10:975 pubmed publisher
Thommen D, Koelzer V, Herzig P, Roller A, Trefny M, Dimeloe S, et al. A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Nat Med. 2018;24:994-1004 pubmed publisher
Felices M, Lenvik A, McElmurry R, Chu S, Hinderlie P, Bendzick L, et al. Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect. JCI Insight. 2018;3: pubmed publisher
Falanga Y, Frascoli M, Kaymaz Y, Forconi C, Ong Echa J, Bailey J, et al. High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells. JCI Insight. 2017;2: pubmed publisher
Barbarin A, Cayssials E, Jacomet F, Núñez N, Basbous S, Lefèvre L, et al. Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases. Front Immunol. 2017;8:316 pubmed publisher
Oja A, Vieira Braga F, Remmerswaal E, Kragten N, Hertoghs K, Zuo J, et al. The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells. Front Immunol. 2017;8:325 pubmed publisher
Jacomet F, Cayssials E, Barbarin A, Desmier D, Basbous S, Lefèvre L, et al. The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia. Front Immunol. 2016;7:688 pubmed publisher
Srivastava R, Khan A, Garg S, Syed S, Furness J, Vahed H, et al. Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocula. J Virol. 2017;91: pubmed publisher
Marquardt N, Ivarsson M, Sundström E, Akesson E, Martini E, Eidsmo L, et al. Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid. J Immunol. 2016;197:3069-3075 pubmed
Hoffmann M, Pantazis N, Martin G, Hickling S, Hurst J, Meyerowitz J, et al. Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. PLoS Pathog. 2016;12:e1005661 pubmed publisher
Johnson S, Eller M, Teigler J, Maloveste S, Schultz B, Soghoian D, et al. Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia. J Virol. 2015;89:7494-505 pubmed publisher
Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson M, Michaelsson J, et al. T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection. PLoS Pathog. 2014;10:e1004251 pubmed publisher
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed publisher
Intlekofer A, Banerjee A, Takemoto N, Gordon S, Dejong C, Shin H, et al. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science. 2008;321:408-11 pubmed publisher
Intlekofer A, Takemoto N, Wherry E, Longworth S, Northrup J, Palanivel V, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005;6:1236-44 pubmed
Pearce E, Mullen A, Martins G, Krawczyk C, Hutchins A, Zediak V, et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science. 2003;302:1041-3 pubmed
Russ A, Wattler S, Colledge W, Aparicio S, Carlton M, Pearce J, et al. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature. 2000;404:95-9 pubmed
Hancock S, Agulnik S, Silver L, Papaioannou V. Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin. Mech Dev. 1999;81:205-8 pubmed
Ciruna B, Rossant J. Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev. 1999;81:199-203 pubmed
Ryan K, Garrett N, Mitchell A, Gurdon J. Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell. 1996;87:989-1000 pubmed
product information
Product Type :
Antibody
Product Name :
EOMES Monoclonal Antibody (WD1928), eFluor™ 660, eBioscience
Catalog # :
50-4877-41
Quantity :
25 Tests
Price :
US 193.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Porcine
Applications :
Flow Cytometry: 5 µL (0.03 µg)/test
Species :
Human, Porcine
Clone :
WD1928
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
TBR2 is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation. TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.03 µg)/test
Aliases :
C77258; EOMES; eomesodermin; eomesodermin homolog; eomesodermin homolog (Xenopus laevis); T-box brain protein 2; T-box transcription factor; TBR2; TBR-2; T-brain-2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA