CD146 Monoclonal Antibody (P1H12), eFluor 660, eBioscience™ | Invitrogen 50-1469-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD146 Monoclonal Antibody (P1H12), eFluor 660, eBioscience™

catalog :

50-1469-41

quantity :

25Tests

price :

US 128

clonality :

monoclonal

host :

mouse

conjugate :

efluor 660

clone name :

P1H12

reactivity :

human, mouse, dogs, domestic rabbit

application :

flow cytometry

citations: 9

Reference
Al Rekabi Z, Fura A, Juhlin I, Yassin A, Popowics T, Sniadecki N. Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells. Cell Adh Migr. 2019;13:138-150 pubmed publisher
Yianni V, Sharpe P. Molecular Programming of Perivascular Stem Cell Precursors. Stem Cells. 2018;36:1890-1904 pubmed publisher
Somasundaram R, Zhang G, Fukunaga Kalabis M, Perego M, Krepler C, Xu X, et al. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat Commun. 2017;8:607 pubmed publisher
Agarwal S, Loder S, Sorkin M, Li S, Shrestha S, Zhao B, et al. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. Stem Cells. 2016;34:1692-701 pubmed publisher
Moradi I, Behjati M, Kazemi M. Application of anodized titanium for enhanced recruitment of endothelial progenitor cells. Nanoscale Res Lett. 2012;7:298 pubmed publisher
Lamerato Kozicki A, Helm K, Jubala C, Cutter G, Modiano J. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol. 2006;34:870-8 pubmed
Elshal M, Khan S, Takahashi Y, Solomon M, McCoy J. CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood. 2005;106:2923-4 pubmed
Solovey A, Gui L, Chang L, Enenstein J, Browne P, Hebbel R. Identification and functional assessment of endothelial P1H12. J Lab Clin Med. 2001;138:322-31 pubmed
Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel R. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med. 1997;337:1584-90 pubmed

product information

Product Type :

Antibody

Product Name :

CD146 Monoclonal Antibody (P1H12), eFluor 660, eBioscience™

Catalog # :

50-1469-41

Quantity :

25Tests

Price :

US 128

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rabbit

Applications :

Flow Cytometry: 5 µL (0.06 µg)/test

Species :

Canine, Human, Mouse, Rabbit

Clone :

P1H12

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.06 µg)/test

Aliases :

1-gicerin; AV025631; CD146; CD149; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Gicerin; HEMCAM; l-gicerin; l-gicerin protein; MCAM; melanoma adhesion molecule; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; Muc18; s-endo; S-endo 1 endothelial-associated antigen; s-gicerin