CD11b/c Monoclonal Antibody (OX42), eFluor 660, eBioscience™ | Invitrogen 50-0110-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD11b/c Monoclonal Antibody (OX42), eFluor 660, eBioscience™

catalog :

50-0110-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

efluor 660

clone name :

OX42

reactivity :

rat

application :

flow cytometry

citations: 5

Reference
Sun X, Liu Y, Lv Z, Yang L, Hu S, Zheng H, et al. rSj16, a recombinant protein of Schistosoma japonicum-derived molecule, reduces severity of the complete Freund's adjuvant-induced adjuvant arthritis in rats' model. Parasite Immunol. 2010;32:739-48 pubmed publisher
He J, Yin Y, Luster T, Watkins L, Thorpe P. Antiphosphatidylserine antibody combined with irradiation damages tumor blood vessels and induces tumor immunity in a rat model of glioblastoma. Clin Cancer Res. 2009;15:6871-80 pubmed publisher
Turnbull E, Yrlid U, Jenkins C, Macpherson G. Intestinal dendritic cell subsets: differential effects of systemic TLR4 stimulation on migratory fate and activation in vivo. J Immunol. 2005;174:1374-84 pubmed
Drasković Pavlović B, van der Laan L, Pejnovic N, Dijkstra C, Colic M. Differential effects of anti-rat CD11b monoclonal antibodies on granulocyte adhesiveness. Immunology. 1999;96:83-9 pubmed
Robinson A, White T, Mason D. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology. 1986;57:239-47 pubmed

product information

Product Type :

Antibody

Product Name :

CD11b/c Monoclonal Antibody (OX42), eFluor 660, eBioscience™

Catalog # :

50-0110-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Rat

Applications :

Flow Cytometry: 0.125 µg/test

Species :

Rat

Clone :

OX42

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. CD11b is also a receptor for fibrogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% thymocytes and is commonly used as a microgial marker in nervous tissue. CD11c encodes the integrin alpha X chain protein. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Mutations affecting the CD11b/c gene lead to systemic lupus erythematosus 6.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test

Aliases :

AI449405; antigen CD11b (p170); CD11 antigen-like family member B; CD11 antigen-like family member C; CD11b; CD11B (p170); CD11b/CD18; CD11bc; CD11C; CD11C (p150) alpha polypeptide; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component 3 receptor 4 subunit; complement component receptor 3 alpha-a; complement receptor 4; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; Cr4; F730045J24Rik; integrin alpha M; integrin alpha X; integrin alpha-M; Integrin alpha-X; integrin aX; integrin subunit alpha M; integrin subunit alpha X; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5; leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; Ly-40; MAC1; MAC-1; Mac-1 alpha; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; myeloid membrane antigen, alpha subunit; N418; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; OX42; OX-42; p150 95 integrin alpha chain; RGD1561123; SLEB6