This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CIITA Polyclonal Antibody
catalog :
49-1001
quantity :
50µg
price :
US 331.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
product information
Product Type :
Antibody
Product Name :
CIITA Polyclonal Antibody
Catalog # :
49-1001
Quantity :
50µg
Price :
US 331.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
ChIP assay: 5-7 µg
Species :
Human
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
CIITA contains an acidic transcriptional activation domain, four LRRs (leucine-rich repeats) and a GTP binding domain. It is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. CIITA also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
Immunogen :
Raised against recombinant CIITA protein.
Format :
Liquid
Applications w/Dilutions :
ChIP assay: 5-7 µg
Aliases :
C2TA, CIITAIV, MHC2TA, NLRA, MHC class II transactivator, MHC class II transactivator type III, NLR family, acid domain containing, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA