Pannexin 1 Polyclonal Antibody | Invitrogen 488100 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pannexin 1 Polyclonal Antibody

catalog :

488100

quantity :

100 µg

price :

US 428

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:250; fig 1	Sword J, Croom D, Wang P, Thompson R, Kirov S. Neuronal pannexin-1 channels are not molecular routes of water influx during spreading depolarization-induced dendritic beading. J Cereb Blood Flow Metab. 2017;37:1626-1633 pubmed publisher
western blot; human; fig 1	Krick S, Wang J, St Pierre M, Gonzalez C, Dahl G, Salathe M. Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production. J Biol Chem. 2016;291:6423-32 pubmed publisher
	Siu R, Kotova A, Timonina K, Zoidl C, Zoidl G. Convergent NMDA receptor-Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36. Commun Biol. 2021;4:702 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Pannexin 1 Polyclonal Antibody

Catalog # :

488100

Quantity :

100 µg

Price :

US 428

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20°C

Description :

The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and 92% homologous to human sequence.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL

Aliases :

AI847747; innexin; MRS1; Pannexin 1; pannexin-1; Panx1; px1; UNQ2529; UNQ2529/PRO6028

more info or order :

Invitrogen product webpage