Pannexin 1 Polyclonal Antibody | Invitrogen 487900 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pannexin 1 Polyclonal Antibody

catalog :

487900

quantity :

100 µg

price :

US 428

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:100; fig 2	Seref Ferlengez Z, Maung S, Schaffler M, Spray D, Suadicani S, Thi M. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS ONE. 2016;11:e0155107 pubmed publisher
	Nouri Nejad D, O Donnell B, Patil C, Sanchez Pupo R, Johnston D, Sayedyahossein S, et al. Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. Mol Biol Cell. 2021;:mbcE19100585 pubmed publisher
	Seref Ferlengez Z, Urban Maldonado M, Sun H, Schaffler M, Suadicani S, Thi M. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019;1442:79-90 pubmed publisher
	Zorzi V, Paciello F, Ziraldo G, Peres C, Mazzarda F, Nardin C, et al. Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function. Front Mol Neurosci. 2017;10:379 pubmed publisher
	Keller A, Diederich L, Panknin C, DeLalio L, Drake J, Sherman R, et al. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017;313:C593-C603 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Pannexin 1 Polyclonal Antibody

Catalog # :

487900

Quantity :

100 µg

Price :

US 428

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL

Species :

Mouse

Isotype :

IgG

Storage :

-20°C

Description :

The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

Immunogen :

Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and human sequences.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL

Aliases :

AI847747; innexin; MRS1; Pannexin 1; pannexin-1; Panx1; px1; UNQ2529; UNQ2529/PRO6028

more info or order :

Invitrogen product webpage