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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Pannexin 1 Polyclonal Antibody
catalog :
487900
quantity :
100 µg
price :
US 428
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, immunohistochemistry
more info or order :
citations: 5
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:100; fig 2
Seref Ferlengez Z, Maung S, Schaffler M, Spray D, Suadicani S, Thi M. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS ONE. 2016;11:e0155107 pubmed publisher
Nouri Nejad D, O Donnell B, Patil C, Sanchez Pupo R, Johnston D, Sayedyahossein S, et al. Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. Mol Biol Cell. 2021;:mbcE19100585 pubmed publisher
Seref Ferlengez Z, Urban Maldonado M, Sun H, Schaffler M, Suadicani S, Thi M. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019;1442:79-90 pubmed publisher
Zorzi V, Paciello F, Ziraldo G, Peres C, Mazzarda F, Nardin C, et al. Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function. Front Mol Neurosci. 2017;10:379 pubmed publisher
Keller A, Diederich L, Panknin C, DeLalio L, Drake J, Sherman R, et al. Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. Am J Physiol Cell Physiol. 2017;313:C593-C603 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Pannexin 1 Polyclonal Antibody
Catalog # :
487900
Quantity :
100 µg
Price :
US 428
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Mouse
Applications :
Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL
Species :
Mouse
Isotype :
IgG
Storage :
-20°C
Description :
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
Immunogen :
Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and human sequences.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry: 2-4 µg/mL, Western Blot: 1-3 µg/mL
Aliases :
AI847747; innexin; MRS1; Pannexin 1; pannexin-1; Panx1; px1; UNQ2529; UNQ2529/PRO6028
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA