Gata-3 Monoclonal Antibody (TWAJ), eFluor 450, eBioscience | Invitrogen 48-9966-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Gata-3 Monoclonal Antibody (TWAJ), eFluor 450, eBioscience

catalog :

48-9966-42

quantity :

100 Tests

price :

US 442.00

clonality :

monoclonal

host :

rat

conjugate :

eFluor 450

clone name :

TWAJ

reactivity :

human, mouse, pigs , rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig s1j	Geng X, Wang C, Gao X, Chowdhury P, Weiss J, Villegas J, et al. GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms. Blood Cancer J. 2022;12:149 pubmed publisher
	Jacenik D, Karagiannidis I, Beswick E. Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. Br J Cancer. 2023;128:387-397 pubmed publisher
	Korniotis S, Saichi M, Trichot C, Hoffmann C, Amblard E, Viguier A, et al. GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner. J Cell Sci. 2022;135: pubmed publisher
	Antunes K, Cass xe3 o G, Santos L, Borges S, Poppe J, Gon xe7 alves J, et al. Airway Administration of Bacterial Lysate OM-85 Protects Mice Against Respiratory Syncytial Virus Infection. Front Immunol. 2022;13:867022 pubmed publisher
	Wilfahrt D, Philips R, Lama J, Kizerwetter M, Shapiro M, McCue S, et al. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. elife. 2021;10: pubmed publisher
	Kalim K, Yang J, Modur V, Nguyen P, Li Y, Zheng Y, et al. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Front Immunol. 2021;12:726393 pubmed publisher
	Chao J, Korzinkin M, Zhavoronkov A, Ozerov I, Walker M, Higgins K, et al. Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med. 2021;2:100399 pubmed publisher
	Verma M, Michalec L, Sripada A, McKay J, Sirohi K, Verma D, et al. The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. J Exp Med. 2021;218: pubmed publisher
	Sanchez Ferras O, Pacis A, Sotiropoulou M, Zhang Y, Wang Y, Bourgey M, et al. A coordinated progression of progenitor cell states initiates urinary tract development. Nat Commun. 2021;12:2627 pubmed publisher
	Zutshi S, Sarode A, Ghosh S, Jha M, Sudan R, Kumar S, et al. LmjF.36.3850, a novel hypothetical Leishmania major protein, contributes to the infection. Immunology. 2021;163:460-477 pubmed publisher
	Zhao X, Zhou L, Chen Z, Ji Y, Peng X, Qi L, et al. The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance. Sci Adv. 2020;6:eaay6191 pubmed publisher
	Stokes J, Hoffman E, Molina M, Kummet N, Simpson R, Zeng Y, et al. Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia. Oncoimmunology. 2020;9:1758011 pubmed publisher
	Eissmann M, Dijkstra C, Jarnicki A, Phesse T, Brunnberg J, Poh A, et al. IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nat Commun. 2019;10:2735 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Gata-3 Monoclonal Antibody (TWAJ), eFluor 450, eBioscience

Catalog # :

48-9966-42

Quantity :

100 Tests

Price :

US 442.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse, Porcine, Rhesus Monkey

Applications :

Flow Cytometry: 5 uL (0.25 ug)/test

Species :

Human, Mouse, Porcine, Rhesus Monkey

Clone :

TWAJ

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.25 ug)/test

Aliases :

EGK_19445; GATA binding factor-3; GATA binding protein 3; GATA binding protein-3; GATA3; Gata-3; GATA-binding factor 3; GATA-binding protein 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3; Transacting T-cell-specific transcription factor GATA-3

more info or order :

Invitrogen product webpage