TCR V beta 8 Monoclonal Antibody (JR-2), eFluor 450, eBioscience | Invitrogen 48-9890-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 8 Monoclonal Antibody (JR-2), eFluor 450, eBioscience

catalog :

48-9890-41

quantity :

25 Tests

price :

US 134.00

clonality :

monoclonal

host :

mouse

conjugate :

eFluor 450

clone name :

JR-2

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Lima M, Almeida J, Santos A, dos Anjos Teixeira M, Alguero M, Queirós M, et al. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol. 2001;159:1861-8 pubmed
Stuart P, Munn R, DeMoll E, Woodward J. Characterization of human T-cell responses to Yersinia enterocolitica superantigen. Hum Immunol. 1995;43:269-75 pubmed
Choi Y, Kotzin B, Lafferty J, White J, Pigeon M, Kubo R, et al. A method for production of antibodies to human T-cell receptor beta-chain variable regions. Proc Natl Acad Sci U S A. 1991;88:8357-61 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 8 Monoclonal Antibody (JR-2), eFluor 450, eBioscience

Catalog # :

48-9890-41

Quantity :

25 Tests

Price :

US 134.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.25 ug)/test

Species :

Human

Clone :

JR-2

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.25 ug)/test

Aliases :

TCR V beta8; TCRV beta 8; TCRV beta8; Vb8; Vbeta8