TIGIT Monoclonal Antibody (MBSA43), eFluor 450, eBioscience | Invitrogen 48-9500-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TIGIT Monoclonal Antibody (MBSA43), eFluor 450, eBioscience

catalog :

48-9500-42

quantity :

100 Tests

price :

US 420.00

clonality :

monoclonal

host :

mouse

conjugate :

eFluor 450

clone name :

MBSA43

reactivity :

human

application :

flow cytometry

citations: 14

Reference
Murakami H, Takahama S, Akita H, Kobayashi S, Masuta Y, Nagatsuka Y, et al. Circulating tumor-associated antigen-specific IFNγ+4-1BB+ CD8+ T cells as peripheral biomarkers of treatment outcomes in patients with pancreatic cancer. Front Immunol. 2024;15:1363568 pubmed publisher
de Lima M, Machado C, Nascimento D, Silva C, Toller Kawahisa J, Rodrigues T, et al. The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation. Sci Rep. 2023;13:13599 pubmed publisher
Worboys J, Vowell K, Hare R, Ambrose A, Bertuzzi M, Conner M, et al. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nat Commun. 2023;14:5016 pubmed publisher
Asashima H, Axisa P, Pham T, Longbrake E, Ruff W, Lele N, et al. Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis. J Clin Invest. 2022;132: pubmed publisher
Xu K, Wang R, Xie H, Hu L, Wang C, Xu J, et al. Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis. Oncogenesis. 2021;10:66 pubmed publisher
Yu L, Liu X, Wang X, Yan F, Wang P, Jiang Y, et al. TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma. Oncoimmunology. 2021;10:1942673 pubmed publisher
Jung J, Rha M, Sa M, Choi H, Jeon J, Seok H, et al. SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells. Nat Commun. 2021;12:4043 pubmed publisher
Liang Q, Tong L, Xiang L, Shen S, Pan C, Liu C, et al. Correlations of the expression of γδ T cells and their co-stimulatory molecules TIGIT, PD-1, ICOS and BTLA with PR and PIBF in the peripheral blood and decidual tissues of women with unexplained recurrent spontaneous abortion. Clin Exp Immunol. 2021;203:55-65 pubmed publisher
Bailur J, McCachren S, Pendleton K, Vasquez J, Lim H, Duffy A, et al. Risk-associated alterations in marrow T cells in pediatric leukemia. JCI Insight. 2020;5: pubmed publisher
Wierzbinska J, Toth R, Ishaque N, Rippe K, Mallm J, Klett L, et al. Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL. Genome Med. 2020;12:29 pubmed publisher
Vendrame E, Seiler C, Ranganath T, Zhao N, Vergara R, Alary M, et al. TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells. AIDS. 2020;34:801-813 pubmed publisher
Li X, Wang R, Fan P, Yao X, Qin L, Peng Y, et al. A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer. Front Oncol. 2019;9:1066 pubmed publisher
Catakovic K, Gassner F, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, et al. TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. Oncoimmunology. 2017;7:e1371399 pubmed publisher
Belkina A, Snyder Cappione J. OMIP-037: 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets. Cytometry A. 2017;91:175-179 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TIGIT Monoclonal Antibody (MBSA43), eFluor 450, eBioscience

Catalog # :

48-9500-42

Quantity :

100 Tests

Price :

US 420.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

MBSA43

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM