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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MARVELD2 Polyclonal Antibody
catalog :
48-8400
quantity :
100 µg
price :
US 430
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...; fig 4c
  • western blot; human; 1:1000; loading ...; fig 4e
Salomon J, Gaston C, Magescas J, Duvauchelle B, Canioni D, Sengmanivong L, et al. Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Nat Commun. 2017;8:13998 pubmed publisher
Talukdar S, Osan J, Ryan K, Grove B, Perley D, Kumar B, et al. RSV-induced expanded ciliated cells contribute to bronchial wall thickening. Virus Res. 2023;327:199060 pubmed publisher
Bagge J, Padma A, Casselbrant A, Hellstr xf6 m M, Oltean M. Mucosal Recovery after Intestinal Transplantation in the Rat: A Sequential Histological and Molecular Assessment. Eur Surg Res. 2023;64:201-210 pubmed publisher
Bekusova V, Zudova T, Fatyykhov I, Fedorova A, Amasheh S, Markov A. Selective Role of TNFα and IL10 in Regulation of Barrier Properties of the Colon in DMH-Induced Tumor and Healthy Rats. Int J Mol Sci. 2022;23: pubmed publisher
Haas A, Zihni C, Krug S, Maraspini R, Otani T, Furuse M, et al. ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. Cells. 2022;11: pubmed publisher
Huang J, Ge S, Luo D, Du R, Wang Y, Liu W, et al. The endothelium permeability after bioresorbable scaffolds implantation caused by the heterogeneous expression of tight junction proteins. Mater Today Bio. 2022;16:100410 pubmed publisher
Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M. Angulin-1 seals tricellular contacts independently of tricellulin and claudins. J Cell Biol. 2021;220: pubmed publisher
Heymans C, Delcorte O, Spourquet C, Villacorte Tabelin M, Dupasquier S, Achouri Y, et al. Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Sci Rep. 2021;11:14519 pubmed publisher
Delaney C, Farrell M, Doherty C, Brennan K, O Keeffe E, Greene C, et al. Attenuated CSF-1R signalling drives cerebrovascular pathology. EMBO Mol Med. 2021;13:e12889 pubmed publisher
S xf8 fteland J, Bagge J, Padma A, Casselbrant A, Zhu C, Wang Y, et al. Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine. Am J Transplant. 2021;21:2220-2230 pubmed publisher
Smyth T, Veazey J, Eliseeva S, Chalupa D, Elder A, Georas S. Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin. Part Fibre Toxicol. 2020;17:52 pubmed publisher
Zhang J, Qin M, Ye Z, Peng P, Li S, Song Q, et al. Association of tricellulin expression with poor colorectal cancer prognosis and metastasis. Oncol Rep. 2020;44:2174-2184 pubmed publisher
Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani T, Higashi T, et al. The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts. J Biol Chem. 2020;295:4289-4302 pubmed publisher
Otani T, Nguyen T, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol. 2019;218:3372-3396 pubmed publisher
Shimada H, Satohisa S, Kohno T, Konno T, Takano K, Takahashi S, et al. Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer. Oncol Lett. 2017;14:6776-6782 pubmed publisher
Sauer R, Kirchner J, Yang S, Hu L, Leinders M, Sommer C, et al. Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy. Ann N Y Acad Sci. 2017;1405:71-88 pubmed publisher
Sang Q, Li W, Xu Y, Qu R, Xu Z, Feng R, et al. ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open. 2015;4:411-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
MARVELD2 Polyclonal Antibody
Catalog # :
48-8400
Quantity :
100 µg
Price :
US 430
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2-4 µg/mL, Western Blot: 0.25-3 µg/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.
Immunogen :
Recombinant protein derived from the C-terminal region of the human Tricellulin protein (Accession# NP_001033692, Q8N4S9), which is identical to rhesus monkey and chimpanzee sequences, and 89% homologous to rat and mouse, 88% homologous to bovine and canine, and 86% homologous to horse sequence
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2-4 µg/mL, Western Blot: 0.25-3 µg/mL
Aliases :
BC003296; DFNB49; MARVD2; MARVEL (membrane-associating) domain containing 2; MARVEL domain containing 2; MARVEL domain-containing protein 2; Marveld2; Mrvldc2; Tric; Trica; Tricb; Tricc; Tricellulin
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA