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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-13 Monoclonal Antibody (eBio13A), eFluor 450, eBioscience
catalog :
48-7133-82
quantity :
100 µg
price :
US 290
clonality :
monoclonal
host :
rat
conjugate :
eFluor 450
clone name :
eBio13A
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 71
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3g
Hurrell B, Galle Treger L, Jahani P, Howard E, Helou D, Banie H, et al. TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity. Cell Rep. 2019;29:4509-4524.e5 pubmed publisher
  • flow cytometry; mouse; fig s4
Wiesner D, Specht C, Lee C, Smith K, Mukaremera L, Lee S, et al. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog. 2015;11:e1004701 pubmed publisher
Jaeger N, McDonough R, Rosen A, Hernandez Leyva A, Wilson N, Lint M, et al. Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. Cell Rep. 2020;33:108331 pubmed publisher
Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, et al. Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice. Nat Commun. 2020;11:220 pubmed publisher
Galle Treger L, Sankaranarayanan I, Hurrell B, Howard E, Lo R, Maazi H, et al. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nat Commun. 2019;10:713 pubmed publisher
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park J, et al. Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 2018;10:76 pubmed publisher
Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, et al. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis. Immunity. 2018;48:1220-1232.e5 pubmed publisher
Lai D, Tang J, Chen L, Fan E, Scott M, Li Y, et al. Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis. Cell Death Dis. 2018;9:369 pubmed publisher
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, et al. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Immunity. 2018;48:258-270.e5 pubmed publisher
Saigusa R, Asano Y, Taniguchi T, Hirabayashi M, Nakamura K, Miura S, et al. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells. Arthritis Res Ther. 2018;20:23 pubmed publisher
Osbourn M, Soares D, Vacca F, Cohen E, Scott I, Gregory W, et al. HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33. Immunity. 2017;47:739-751.e5 pubmed publisher
Minutti C, Drube S, Blair N, Schwartz C, McCrae J, McKenzie A, et al. Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity. 2017;47:710-722.e6 pubmed publisher
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed publisher
Kim K, Kim N, Lee G. Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. PLoS ONE. 2016;11:e0148576 pubmed publisher
Wei F, Yang D, Tewary P, Li Y, Li S, Chen X, et al. The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant. Cancer Res. 2014;74:5989-98 pubmed publisher
Johnson R, Kerr M, Slaven J. An atypical CD8 T-cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin-13. Immunology. 2014;142:248-57 pubmed publisher
Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S. Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS ONE. 2013;8:e82698 pubmed publisher
Yu X, Pappu R, Ramirez Carrozzi V, Ota N, Caplazi P, Zhang J, et al. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol. 2014;7:730-40 pubmed publisher
Worthington J, Klementowicz J, Rahman S, Czajkowska B, Smedley C, Waldmann H, et al. Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity. PLoS Pathog. 2013;9:e1003675 pubmed publisher
Mielke L, Groom J, Rankin L, Seillet C, Masson F, Putoczki T, et al. TCF-1 controls ILC2 and NKp46+ROR?t+ innate lymphocyte differentiation and protection in intestinal inflammation. J Immunol. 2013;191:4383-91 pubmed publisher
Nussbaum J, Van Dyken S, von Moltke J, Cheng L, Mohapatra A, Molofsky A, et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013;502:245-8 pubmed publisher
Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, et al. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013;191:3614-23 pubmed publisher
Durant L, Makris S, Voorburg C, Loebbermann J, Johansson C, Openshaw P. Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice. J Virol. 2013;87:10946-54 pubmed publisher
Flaczyk A, Duerr C, Shourian M, Lafferty E, Fritz J, Qureshi S. IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans. J Immunol. 2013;191:2503-13 pubmed publisher
Stokes K, Currier M, Sakamoto K, Lee S, Collins P, Plemper R, et al. The respiratory syncytial virus fusion protein and neutrophils mediate the airway mucin response to pathogenic respiratory syncytial virus infection. J Virol. 2013;87:10070-82 pubmed publisher
Wang J, Li F, Sun R, Gao X, Wei H, Li L, et al. Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun. 2013;4:2106 pubmed publisher
Johnson R, Kerr M, Slaven J. Perforin is detrimental to controlling [corrected] C. muridarum replication in vitro, but not in vivo. PLoS ONE. 2013;8:e63340 pubmed publisher
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
Kruijsen D, Einarsdóttir H, Schijf M, Coenjaerts F, van der Schoot E, Vidarsson G, et al. Intranasal administration of antibody-bound respiratory syncytial virus particles efficiently primes virus-specific immune responses in mice. J Virol. 2013;87:7550-7 pubmed publisher
Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, et al. A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLoS ONE. 2013;8:e61785 pubmed publisher
Volkov A, Hagner S, Löser S, Alnahas S, Raifer H, Hellhund A, et al. ?5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma. PLoS ONE. 2013;8:e60565 pubmed publisher
Jia Y, Takeda K, Han J, Joetham A, Marcus R, Lucas J, et al. Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation. J Immunol. 2013;190:4056-65 pubmed publisher
Blum L, Mohanan S, Fabre M, Yafawi R, Appleton J. Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Vet Parasitol. 2013;194:101-5 pubmed publisher
Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, et al. Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. Blood. 2013;121:3274-83 pubmed publisher
Scalfone L, Nel H, Gagliardo L, Cameron J, Al Shokri S, Leifer C, et al. Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis. Infect Immun. 2013;81:1354-63 pubmed publisher
Redpath S, Van Der Werf N, Cervera A, MacDonald A, Gray D, Maizels R, et al. ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection. Eur J Immunol. 2013;43:705-15 pubmed publisher
Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, et al. Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol. 2013;43:606-18 pubmed publisher
Kerzerho J, Maazi H, Speak A, Szely N, Lombardi V, Khoo B, et al. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. J Allergy Clin Immunol. 2013;131:1048-57, 1057.e1-2 pubmed publisher
Donaldson D, Apostolaki M, Bone H, Richards C, Williams N. The Escherichia coli heat-labile enterotoxin B subunit protects from allergic airway disease development by inducing CD4+ regulatory T cells. Mucosal Immunol. 2013;6:535-46 pubmed publisher
Piehler D, Grahnert A, Eschke M, Richter T, Kohler G, Stenzel W, et al. T1/ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis. Mucosal Immunol. 2013;6:405-14 pubmed publisher
Krishnamoorthy N, Khare A, Oriss T, Raundhal M, Morse C, Yarlagadda M, et al. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med. 2012;18:1525-30 pubmed publisher
Schijf M, Kruijsen D, Bastiaans J, Coenjaerts F, Garssen J, van Bleek G, et al. Specific dietary oligosaccharides increase Th1 responses in a mouse respiratory syncytial virus infection model. J Virol. 2012;86:11472-82 pubmed publisher
Rynda Apple A, Dobrinen E, McAlpine M, Read A, Harmsen A, Richert L, et al. Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function. Am J Pathol. 2012;181:196-210 pubmed publisher
Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
Van V, Raymond M, Baba N, Rubio M, Wakahara K, Susin S, et al. CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors. J Immunol. 2012;188:4249-55 pubmed publisher
McNamara J, Schramm C, Singh A, Secor E, Guernsey L, Lefrancois L, et al. Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol. 2012;180:1991-2000 pubmed publisher
Halim T, Krauss R, Sun A, Takei F. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity. 2012;36:451-63 pubmed publisher
Kadri N, Korpos E, Gupta S, Briet C, Löfbom L, Yagita H, et al. CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes. J Immunol. 2012;188:3138-49 pubmed publisher
Muller U, Piehler D, Stenzel W, Kohler G, Frey O, Held J, et al. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol. 2012;5:299-310 pubmed publisher
Schneider D, Hong J, Popova A, Bowman E, Linn M, McLean A, et al. Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness. J Immunol. 2012;188:2894-904 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Nakahira M, Nakanishi K. Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells. Int Immunol. 2011;23:761-72 pubmed publisher
Nakano H, Free M, Whitehead G, Maruoka S, Wilson R, Nakano K, et al. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol. 2012;5:53-65 pubmed publisher
Whitehead G, Wilson R, Nakano K, Burch L, Nakano H, Cook D. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol. 2012;129:207-15.e1-5 pubmed publisher
Barlow J, Flynn R, Ballantyne S, McKenzie A. Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity. Clin Exp Allergy. 2011;41:1447-55 pubmed publisher
Zaccone P, Burton O, Gibbs S, Miller N, Jones F, Schramm G, et al. The S. mansoni glycoprotein ?-1 induces Foxp3 expression in NOD mouse CD4? T cells. Eur J Immunol. 2011;41:2709-18 pubmed publisher
Van Der Werf N, Redpath S, Phythian Adams A, Azuma M, Allen J, Maizels R, et al. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J Immunol. 2011;187:1411-20 pubmed publisher
Anthony R, Kobayashi T, Wermeling F, Ravetch J. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011;475:110-3 pubmed publisher
Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite de Moraes M, et al. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression. Blood. 2011;118:2993-3002 pubmed publisher
Besnard A, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B. IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol. 2011;41:1675-86 pubmed publisher
Kruijsen D, Schijf M, Lukens M, van Uden N, Kimpen J, Coenjaerts F, et al. Local innate and adaptive immune responses regulate inflammatory cell influx into the lungs after vaccination with formalin inactivated RSV. Vaccine. 2011;29:2730-41 pubmed publisher
Hebenstreit D, Gu M, Haider S, Turner D, Lio P, Teichmann S. EpiChIP: gene-by-gene quantification of epigenetic modification levels. Nucleic Acids Res. 2011;39:e27 pubmed publisher
Dewals B, Marillier R, Hoving J, Leeto M, Schwegmann A, Brombacher F. IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. PLoS Negl Trop Dis. 2010;4:e689 pubmed publisher
Cejas P, Walsh M, Pearce E, Han D, Harms G, Artis D, et al. TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood. 2010;115:4750-7 pubmed publisher
Kim S, Prout M, Ramshaw H, Lopez A, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol. 2010;184:1143-7 pubmed publisher
Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, et al. Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation. Am J Respir Crit Care Med. 2010;181:688-98 pubmed publisher
Zaborsky N, Brunner M, Wallner M, Himly M, Karl T, Schwarzenbacher R, et al. Antigen aggregation decides the fate of the allergic immune response. J Immunol. 2010;184:725-35 pubmed publisher
Jin N, Roark C, Miyahara N, Taube C, Aydintug M, Wands J, et al. Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells. J Immunol. 2009;182:2002-10 pubmed publisher
Doganci A, Karwot R, Maxeiner J, Scholtes P, Schmitt E, Neurath M, et al. IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo. J Immunol. 2008;181:1917-26 pubmed
Batten M, Kljavin N, Li J, Walter M, De Sauvage F, Ghilardi N. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol. 2008;180:2752-6 pubmed
Castilow E, Meyerholz D, Varga S. IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease. J Immunol. 2008;180:2376-84 pubmed
product information
Product Type :
Antibody
Product Name :
IL-13 Monoclonal Antibody (eBio13A), eFluor 450, eBioscience
Catalog # :
48-7133-82
Quantity :
100 µg
Price :
US 290
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test
Species :
Mouse
Clone :
eBio13A
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA