This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-6 Monoclonal Antibody (MP5-20F3), eFluor 450, eBioscience
catalog :
48-7061-80
quantity :
25 ug
price :
US 148.00
clonality :
monoclonal
host :
rat
conjugate :
eFluor 450
clone name :
MP5-20F3

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 21
Reference
Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al. Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed publisher
Prasad S, Singh A, Hu S, Sheng W, Chauhan P, Lokensgard J. Dysregulated brain regulatory T cells fail to control reactive gliosis following repeated antigen stimulation. iScience. 2023;26:106628 pubmed publisher
Jeong G, Lee S, Kim D, Lyu J, Yoon G, Kim K, et al. Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model. J Virol. 2023;97:e0055623 pubmed publisher
Elsayed R, Elashiry M, Liu Y, Morandini A, El Awady A, Elashiry M, et al. Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice. Aging Dis. 2023;14:136-151 pubmed publisher
Long F, Bhatti M, Kellenberger A, Sun W, Modica S, H xf6 ring M, et al. A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice. Mol Metab. 2023;69:101675 pubmed publisher
Olou A, Ambrose J, Jack J, Walsh M, Ruckert M, Eades A, et al. SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1. J Cell Commun Signal. 2022;: pubmed publisher
Chen D, Jia G, Zhang Y, Mao H, Zhao L, Li W, et al. Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis. J Neuroinflammation. 2022;19:59 pubmed publisher
Qi M, Xia Y, Wu Y, Zhang Z, Wang X, Lu L, et al. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun. 2022;13:897 pubmed publisher
Luo Y, Guo J, Jia W, Wu M, Yin F, Niu G, et al. TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:3877617 pubmed publisher
Lee G, Liao T, Wu J, Wu K, Kuo C. Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE-/- mice fed high fat diet. J Biomed Sci. 2021;28:74 pubmed publisher
Zhou Z, Choi J, Shin J, Kim D, Kweon B, Oh H, et al. Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice. Int J Mol Sci. 2021;22: pubmed publisher
Rupert J, Narasimhan A, Jengelley D, Jiang Y, Liu J, Au E, et al. Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia. J Exp Med. 2021;218: pubmed publisher
Alford M, Choi K, Trimble M, Masoudi H, Kalsi P, Pletzer D, et al. Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies. Front Cell Infect Microbiol. 2021;11:621081 pubmed publisher
Bottek J, Soun C, Lill J, Dixit A, Thiebes S, Beerlage A, et al. Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder. Mucosal Immunol. 2020;13:702-714 pubmed publisher
Lee D, Lim J, Cho K. Differential Activation of Macrophages Based on Their Environment in Advanced Age. Chonnam Med J. 2020;56:12-19 pubmed publisher
Yeh C, Wu J, Lee G, Wen H, Lin P, Kuo C. Vanadium Derivative Exposure Promotes Functional Alterations of VSMCs and Consequent Atherosclerosis via ROS/p38/NF-κB-Mediated IL-6 Production. Int J Mol Sci. 2019;20: pubmed publisher
Dai D, Yuan J, Wang Y, Xu J, Mao C, Xiao Y. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Sci Rep. 2019;9:8034 pubmed publisher
Wasnik S, Rundle C, Baylink D, Yazdi M, Carreon E, Xu Y, et al. 1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites. JCI Insight. 2018;3: pubmed publisher
Jin W, Shi S, Li Z, Li M, Wood K, Gonzales R, et al. Depletion of microglia exacerbates postischemic inflammation and brain injury. J Cereb Blood Flow Metab. 2017;37:2224-2236 pubmed publisher
Macia A, Vaquero M, Gou Fabregas M, Castelblanco E, Valdivielso J, Anerillas C, et al. Sprouty1 induces a senescence-associated secretory phenotype by regulating NF?B activity: implications for tumorigenesis. Cell Death Differ. 2014;21:333-43 pubmed publisher
Wu Y, El Shikh M, El Sayed R, Best A, Szakal A, Tew J. IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation. Int Immunol. 2009;21:745-56 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-6 Monoclonal Antibody (MP5-20F3), eFluor 450, eBioscience
Catalog # :
48-7061-80
Quantity :
25 ug
Price :
US 148.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
MP5-20F3
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA