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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IgD Monoclonal Antibody (11-26c (11-26)), eFluor 450, eBioscience
catalog :
48-5993-82
quantity :
100 µg
price :
US 227
clonality :
monoclonal
host :
rat
conjugate :
eFluor 450
clone name :
11-26c (11-26)
reactivity :
mouse
application :
flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 83
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 1c
Cho S, Lee H, Yu I, Choi Y, Huang H, Hashemifar S, et al. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018;9:2757 pubmed publisher
  • flow cytometry; mouse; 1:200; tbl 1
Jackson Jones L, Duncan S, Magalhaes M, Campbell S, Maizels R, McSorley H, et al. Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nat Commun. 2016;7:12651 pubmed publisher
  • flow cytometry; mouse; fig 4e
Yockey L, Demehri S, Turkoz M, Turkoz A, Ahern P, Jassim O, et al. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013;133:2714-2721 pubmed publisher
Liu R, King A, Bouillet P, Tarlinton D, Strasser A, Heierhorst J. Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner. Front Immunol. 2018;9:592 pubmed publisher
Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214:1181-1198 pubmed publisher
Srikakulapu P, Hu D, Yin C, Mohanta S, Bontha S, Peng L, et al. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-85 pubmed publisher
Dang A, Tesfagiorgis Y, Jain R, Craig H, Kerfoot S. Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease. Front Immunol. 2015;6:470 pubmed publisher
Moreau J, Berger A, Nelles M, Mielnik M, Furlonger C, Cen S, et al. Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses. Blood. 2015;126:1184-92 pubmed publisher
Jacque E, Schweighoffer E, Tybulewicz V, Ley S. BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J Exp Med. 2015;212:883-92 pubmed publisher
Kleiman E, Salyakina D, de Heusch M, Hoek K, Llanes J, Castro I, et al. Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen. Front Immunol. 2015;6:30 pubmed publisher
Cho J, Seo J, Lim C, Yang L, Shiratsuchi T, Lee M, et al. Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ. 2015;22:1437-50 pubmed publisher
Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS ONE. 2015;10:e0117566 pubmed publisher
Hoyt T, Dobrinen E, Kochetkova I, Meissner N. B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent. Infect Immun. 2015;83:743-58 pubmed publisher
Nair N, Buti L, Faenzi E, Buricchi F, Nuti S, Sammicheli C, et al. Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo. Immun Inflamm Dis. 2013;1:3-13 pubmed publisher
Azcárate I, Marín García P, Kamali A, Pérez Benavente S, Puyet A, Diez A, et al. Differential immune response associated to malaria outcome is detectable in peripheral blood following Plasmodium yoelii infection in mice. PLoS ONE. 2014;9:e85664 pubmed publisher
Racine J, Wang M, Zhang M, Zeng D. Induction of mixed chimerism depletes pre-existing and de novo-developed autoreactive B cells in autoimmune NOD mice. Diabetes. 2014;63:2051-62 pubmed publisher
Goenka R, Scholz J, Naradikian M, Cancro M. Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. Exp Gerontol. 2014;54:109-15 pubmed publisher
Heizmann B, Kastner P, Chan S. Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals. J Exp Med. 2013;210:2823-32 pubmed publisher
Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, et al. Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. J Biol Chem. 2013;288:33449-61 pubmed publisher
Boulianne B, Le M, Ward L, Meng L, Haddad D, Li C, et al. AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely. J Immunol. 2013;191:4521-30 pubmed publisher
Lindner J, Wong C, Möller A, Nielsen P. A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1. Mol Cell Biol. 2013;33:4628-40 pubmed publisher
Mok Y, Schwierzeck V, Thomas D, Vigorito E, Rayner T, Jarvis L, et al. MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production. J Immunol. 2013;191:3037-3048 pubmed publisher
Chen Y, Zhang J, Hwang K, Bouton Verville H, Xia S, Newman A, et al. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol. 2013;191:1260-75 pubmed publisher
Donius L, Handy J, Weis J, Weis J. Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol. 2013;191:434-47 pubmed publisher
Agnello D, Denimal D, Lavaux A, Blondeau Germe L, Lu B, Gerard N, et al. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol. 2013;190:4836-47 pubmed publisher
Billich A, Baumruker T, Beerli C, Bigaud M, Bruns C, Calzascia T, et al. Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS ONE. 2013;8:e59630 pubmed publisher
Halemano K, Barrett B, Li S, Harper M, Smith D, Heilman K, et al. Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice. PLoS ONE. 2013;8:e60500 pubmed publisher
Zhou X, Xiang Y, Ding X, Garrard W. Loss of an Ig? gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation. Mol Cell Biol. 2013;33:2091-101 pubmed publisher
Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013;190:2080-9 pubmed publisher
Crump K, Langston P, Rajkarnikar S, Grayson J. Antioxidant treatment regulates the humoral immune response during acute viral infection. J Virol. 2013;87:2577-86 pubmed publisher
Biswas P, Kang K, Gupta S, Bhagat G, Pernis A. A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21. Methods Mol Biol. 2012;900:233-51 pubmed publisher
Glatman Zaretsky A, Silver J, Siwicki M, Durham A, Ware C, Hunter C. Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture. Infect Immun. 2012;80:3602-10 pubmed publisher
Goulding J, Bogue R, Tahiliani V, Croft M, Salek Ardakani S. CD8 T cells are essential for recovery from a respiratory vaccinia virus infection. J Immunol. 2012;189:2432-40 pubmed publisher
Nijnik A, Clare S, Hale C, Chen J, Raisen C, Mottram L, et al. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol. 2012;189:102-11 pubmed publisher
Scatizzi J, Haraldsson M, Pollard K, Theofilopoulos A, Kono D. The Lbw2 locus promotes autoimmune hemolytic anemia. J Immunol. 2012;188:3307-14 pubmed publisher
McNamee E, Masterson J, Jedlicka P, Collins C, Williams I, Rivera Nieves J. Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis. Gut. 2013;62:53-62 pubmed publisher
Rankin A, Guay H, Herber D, Bertino S, Duzanski T, Carrier Y, et al. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. J Immunol. 2012;188:1656-67 pubmed publisher
Vosters J, Roescher N, Illei G, Chiorini J, Tak P. TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice. Oral Dis. 2012;18:365-74 pubmed publisher
Chaimowitz N, Martin R, Cichy J, Gibb D, Patil P, Kang D, et al. A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture. J Immunol. 2011;187:5114-22 pubmed publisher
Garchow B, Bartulos Encinas O, Leung Y, Tsao P, Eisenberg R, Caricchio R, et al. Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol Med. 2011;3:605-15 pubmed publisher
Corfe S, Rottapel R, Paige C. Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells. J Immunol. 2011;187:3499-510 pubmed publisher
Pordes A, Baumgartner C, Allacher P, Ahmad R, Weiller M, Schiviz A, et al. T cell-independent restimulation of FVIII-specific murine memory B cells is facilitated by dendritic cells together with toll-like receptor 7 agonist. Blood. 2011;118:3154-62 pubmed publisher
Fujii H, Ato M, Takahashi Y, Otake K, Hashimoto S, Kaji T, et al. HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice. Int Immunol. 2011;23:433-41 pubmed publisher
Savelyeva N, Shipton M, Suchacki A, Babbage G, Stevenson F. High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen. Blood. 2011;118:650-9 pubmed publisher
Salek Ardakani S, Choi Y, Rafii El Idrissi Benhnia M, Flynn R, Arens R, Shoenberger S, et al. B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus. J Immunol. 2011;186:5294-303 pubmed publisher
Ackermann J, Radtke D, Maurberger A, Winkler T, Nitschke L. Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO J. 2011;30:1621-33 pubmed publisher
Gardam S, Turner V, Anderton H, Limaye S, Basten A, Koentgen F, et al. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011;117:4041-51 pubmed publisher
Phares T, Marques C, Stohlman S, Hinton D, Bergmann C. Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol. 2011;85:2589-98 pubmed publisher
Racine R, McLaughlin M, Jones D, Wittmer S, MacNamara K, Woodland D, et al. IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection. J Immunol. 2011;186:1011-21 pubmed publisher
Stumhofer J, Tait E, Quinn W, Hosken N, Spudy B, Goenka R, et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol. 2010;11:1119-26 pubmed publisher
DeKoter R, Geadah M, Khoosal S, Xu L, Thillainadesan G, Torchia J, et al. Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C. J Immunol. 2010;185:7374-84 pubmed publisher
Rahman Z, Shao W, Khan T, Zhen Y, Cohen P. Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J Immunol. 2010;185:5859-68 pubmed publisher
Weisel F, Appelt U, Schneider A, Horlitz J, Van Rooijen N, Korner H, et al. Unique requirements for reactivation of virus-specific memory B lymphocytes. J Immunol. 2010;185:4011-21 pubmed publisher
Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace W, et al. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity. 2010;33:71-83 pubmed publisher
Haynes N, Hawkins E, Li M, McLaughlin N, Hämmerling G, Schwendener R, et al. CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. J Immunol. 2010;185:532-41 pubmed publisher
Johnson B, Kahler D, Baban B, Chandler P, Kang B, Shimoda M, et al. B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A. 2010;107:10644-8 pubmed publisher
Nealy M, Coleman C, Li H, Tibbetts S. Use of a virus-encoded enzymatic marker reveals that a stable fraction of memory B cells expresses latency-associated nuclear antigen throughout chronic gammaherpesvirus infection. J Virol. 2010;84:7523-34 pubmed publisher
Duong B, Ota T, Ait Azzouzene D, Aoki Ota M, VELA J, Huber C, et al. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J Immunol. 2010;184:4143-58 pubmed publisher
Roundy K, Jacobson A, Weis J, Weis J. The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors. Eur J Immunol. 2010;40:1139-49 pubmed publisher
Sadri N, Lu J, Badura M, Schneider R. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunol. 2010;11:1 pubmed publisher
Zaheen A, Boulianne B, Parsa J, Ramachandran S, Gommerman J, Martin A. AID constrains germinal center size by rendering B cells susceptible to apoptosis. Blood. 2009;114:547-54 pubmed publisher
Meyer Bahlburg A, Bandaranayake A, Andrews S, Rawlings D. Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals. J Immunol. 2009;182:4065-75 pubmed publisher
Parameswaran R, Ben David H, Sharabi A, Zinger H, Mozes E. B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus. Clin Immunol. 2009;131:223-32 pubmed publisher
Dengler H, Baracho G, Omori S, Bruckner S, Arden K, Castrillon D, et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol. 2008;9:1388-98 pubmed publisher
Benson M, Dillon S, Castigli E, Geha R, Xu S, Lam K, et al. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol. 2008;180:3655-9 pubmed
Hager E, Tse H, Piganelli J, Gupta M, Baetscher M, Tse T, et al. Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis. 2007;30:888-95 pubmed
Coffey F, Liu X, Manser T. Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs. J Immunol. 2007;179:6663-72 pubmed
Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry M, Shlomchik M. Depletion of B cells in murine lupus: efficacy and resistance. J Immunol. 2007;179:3351-61 pubmed
Forster N, Gallinat S, Jablonska J, Weiss S, Elsässer H, Lutz W. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol. 2007;178:6941-8 pubmed
Zhou B, Wang S, Mayr C, Bartel D, Lodish H. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007;104:7080-5 pubmed
Liu X, Wysocki L, Manser T. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci. J Immunol. 2007;178:5035-47 pubmed
Jin W, Reiley W, Lee A, Wright A, Wu X, Zhang M, et al. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem. 2007;282:15884-93 pubmed
Schwickert T, Lindquist R, Shakhar G, Livshits G, Skokos D, Kosco Vilbois M, et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature. 2007;446:83-7 pubmed
Kotani A, Kakazu N, Tsuruyama T, Okazaki I, Muramatsu M, Kinoshita K, et al. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proc Natl Acad Sci U S A. 2007;104:1616-20 pubmed
Fallas J, Yi W, Draghi N, O Rourke H, Denzin L. Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function. J Immunol. 2007;178:1488-97 pubmed
Rahman Z, Alabyev B, Manser T. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. J Immunol. 2007;178:897-907 pubmed
Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, et al. RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood. 2007;109:2346-55 pubmed
Heltemes Harris L, Liu X, Manser T. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005;17:1447-61 pubmed
Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran A, Martensson I. Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol. 2005;35:1969-76 pubmed
Wen L, Shinton S, Hardy R, Hayakawa K. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol. 2005;174:6918-26 pubmed
Baba T, Fusaki N, Aoyama A, Li D, Okamura R, Parnes J, et al. Dual regulation of BCR-mediated growth inhibition signaling by CD72. Eur J Immunol. 2005;35:1634-42 pubmed
Gatto D, Pfister T, Jegerlehner A, Martin S, Kopf M, Bachmann M. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med. 2005;201:993-1005 pubmed
Rice J, Newman J, Wang C, Michael D, Diamond B. Receptor editing in peripheral B cell tolerance. Proc Natl Acad Sci U S A. 2005;102:1608-13 pubmed
product information
Product Type :
Antibody
Product Name :
IgD Monoclonal Antibody (11-26c (11-26)), eFluor 450, eBioscience
Catalog # :
48-5993-82
Quantity :
100 µg
Price :
US 227
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
11-26c (11-26)
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
This type I transmembrane protein is co-expressed on the surface of mature naive B cells with membrane IgM. IgD also exists as a soluble form in blood serum. Studies have demonstrated that IgD associates with the B cell receptor and participates in mediating signal transduction upon antigen binding.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
IgD; Igh-5; IGHD; immunoglobulin heavy constant delta
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA