CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), eFluor 450, eBioscience | Invitrogen 48-5971-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), eFluor 450, eBioscience

catalog :

48-5971-82

quantity :

100 µg

price :

US 334

clonality :

monoclonal

host :

rat

conjugate :

eFluor 450

clone name :

DX5

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Larsen J, Dall M, Antvorskov J, Weile C, Engkilde K, Josefsen K, et al. Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion. Eur J Immunol. 2014;44:3056-67 pubmed publisher
	Dodard G, Tata A, Erick T, Jaime D, Miah S, Quatrini L, et al. Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells. Cell Rep. 2020;32:107855 pubmed publisher
	Khiew S, Jain D, Chen J, Yang J, Yin D, Young J, et al. Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells. J Clin Invest. 2020;130:3453-3466 pubmed publisher
	Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
	Si Y, Wen Y, Kelly S, Chong A, Collier J. Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses. J Control Release. 2018;282:120-130 pubmed publisher
	Khiew S, Yang J, Young J, Chen J, Wang Q, Yin D, et al. CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight. 2017;2: pubmed publisher
	Van Dyken S, Liang H, Naikawadi R, Woodruff P, Wolters P, Erle D, et al. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017;169:497-509.e13 pubmed publisher
	Zilio S, Vella J, De La Fuente A, Daftarian P, Weed D, Kaifer A, et al. 4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells. J Immunol. 2017;198:4166-4177 pubmed publisher
	Lehmann C, Baranska A, Heidkamp G, Heger L, Neubert K, Lühr J, et al. DC subset-specific induction of T cell responses upon antigen uptake via Fc? receptors in vivo. J Exp Med. 2017;214:1509-1528 pubmed publisher
	Ender F, Wiese A, Schmudde I, Sun J, Vollbrandt T, Konig P, et al. Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. PLoS ONE. 2017;12:e0172446 pubmed publisher
	Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
	Palmer V, Aziz Seible R, Kassmeier M, Rothermund M, Perry G, Swanson P. VprBP Is Required for Efficient Editing and Selection of IgÎº+ B Cells, but Is Dispensable for IgÎ»+ and Marginal Zone B Cell Maturation and Selection. J Immunol. 2015;195:1524-37 pubmed publisher
	Karsten C, Laumonnier Y, Eurich B, Ender F, BrÃ¶ker K, Roy S, et al. Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol. 2015;194:1841-55 pubmed publisher
	Pyzik M, Dumaine A, Dumaine A, Charbonneau B, Fodil Cornu N, Jonjic S, et al. Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo. J Immunol. 2014;193:6061-9 pubmed publisher
	Adlercreutz E, Weile C, Larsen J, Engkilde K, Agardh D, Buschard K, et al. A gluten-free diet lowers NKG2D and ligand expression in BALB/c and non-obese diabetic (NOD) mice. Clin Exp Immunol. 2014;177:391-403 pubmed publisher
	Hsieh Y, Fu C, Hsieh M. Helminth-induced interleukin-4 abrogates invariant natural killer T cell activation-associated clearance of bacterial infection. Infect Immun. 2014;82:2087-97 pubmed publisher
	Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
	Bulliard Y, Jolicoeur R, Windman M, Rue S, Ettenberg S, Knee D, et al. Activating Fc ? receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93 pubmed publisher
	Goulding J, Bogue R, Tahiliani V, Croft M, Salek Ardakani S. CD8 T cells are essential for recovery from a respiratory vaccinia virus infection. J Immunol. 2012;189:2432-40 pubmed publisher
	Cheung T, Oborne L, Steinberg M, Macauley M, Fukuyama S, Sanjo H, et al. T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. J Immunol. 2009;183:7286-96 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), eFluor 450, eBioscience

Catalog # :

48-5971-82

Quantity :

100 µg

Price :

US 334

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test

Species :

Mouse

Clone :

DX5

Isotype :

IgM, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test

Aliases :

alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2

more info or order :

Invitrogen product webpage