TLR4 Polyclonal Antibody | Invitrogen 48-2300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR4 Polyclonal Antibody

catalog :

48-2300

quantity :

100 µg

price :

425 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rat; 1:500; loading ...; fig 2	Famakin B, Tsymbalyuk O, Tsymbalyuk N, Ivanova S, Woo S, Kwon M, et al. HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia. Neurol Res Int. 2020;2020:3929438 pubmed publisher
	Hussain S, Johnson C, Sciurba J, Meng X, Stober V, Liu C, et al. TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. elife. 2020;9: pubmed publisher
	Zhang L, Chen Q, Wang H, Yang J, Sheng S. Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway. Mol Med Rep. 2018;18:5427-5436 pubmed publisher
	Bueno Silva B, Kawamoto D, Ando Suguimoto E, Alencar S, Rosalen P, Mayer M. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE. 2015;10:e0144954 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TLR4 Polyclonal Antibody

Catalog # :

48-2300

Quantity :

100 µg

Price :

425 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 20 µg x 10^6 cells, Immunoprecipitation: Assay Dependent, Western Blot: 1:50-1:200

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20°C

Description :

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Immunogen :

Synthetic peptide derived from the C-terminal region of the mouse TLR4 protein (Accession# NP_067272, Q9QUK6), which is identical to rat and 94% homologous to human.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 20 µg x 10^6 cells, Immunoprecipitation: Assay Dependent, Western Blot: 1:50-1:200

Aliases :

ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein

more info or order :

Invitrogen product webpage