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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SOX2 Polyclonal Antibody
catalog :
48-1400
quantity :
100 µg
price :
US 450
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:125; loading ...; fig 4s1b
Battaglia R, Beltran A, Delic S, Dumitru R, Robinson J, Kabiraj P, et al. Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig e2a, e2d
  • western blot; mouse; 1:250; loading ...; fig e1c
Strebinger D, Deluz C, Friman E, Govindan S, Alber A, Suter D. Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions. Mol Syst Biol. 2019;15:e9002 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 1h
Deluz C, Friman E, Strebinger D, Benke A, Raccaud M, Callegari A, et al. A role for mitotic bookmarking of SOX2 in pluripotency and differentiation. Genes Dev. 2016;30:2538-2550 pubmed
  • immunocytochemistry; rat; 1:100; fig 5
Cui Y, Han J, Xiao Z, Chen T, Wang B, Chen B, et al. The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation. Sci Rep. 2016;6:23300 pubmed publisher
Gulaia V, Shmelev M, Romanishin A, Shved N, Farniev V, Goncharov N, et al. Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors. Sci Rep. 2022;12:18975 pubmed publisher
Morelli M, Lessi F, Barachini S, Liotti R, Montemurro N, Perrini P, et al. Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early. Front Oncol. 2022;12:969812 pubmed publisher
Yao H, Liu M, Wang L, Zu Y, WU C, Li C, et al. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res. 2022;32:570-584 pubmed publisher
Raad S, David A, Chung W, Faure C. Generation of three induced pluripotent stem cells lines from patients with esophageal atresia/tracheoesophageal fistula type C. Stem Cell Res. 2022;60:102711 pubmed publisher
Paterson C, Kilmister E, Brasch H, Bockett N, Patel J, Paterson E, et al. Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma. Life (Basel). 2021;11: pubmed publisher
Coughlin T, Sana A, Voss K, Gadi A, Basu Roy U, Curtin C, et al. The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells. Cancers (Basel). 2021;13: pubmed publisher
Herrera A, Menendez A, Torroba B, Ochoa A, Pons S. Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity. J Cell Biol. 2021;220: pubmed publisher
Luke Krishnan C, Brasch H, Patel J, Bockett N, Paterson E, Davis P, et al. Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation. Front Surg. 2021;8:621089 pubmed publisher
Aslam N, Abusharieh E, Abuarqoub D, Ali D, Al Hattab D, Wehaibi S, et al. Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro. Mol Ther Oncolytics. 2021;20:147-165 pubmed publisher
Zhang D, McLenachan S, Chen S, Zaw K, Alziyadat Y, Zhang X, et al. Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200. Stem Cell Res. 2021;51:102154 pubmed publisher
Rami A, x141 aczma x144 ski x, Jack xf3 w Nowicka J, Jack xf3 w J. Reprogramming and Differentiation of Cutaneous Squamous Cell Carcinoma Cells in Recessive Dystrophic Epidermolysis Bullosa. Int J Mol Sci. 2020;22: pubmed publisher
Zaw K, Wong E, Zhang X, Zhang D, Chen S, Thompson J, et al. Generation of three induced pluripotent stem cell lines from a patient with Usher syndrome caused by biallelic c.949C > A and c.1256G > T mutations in the USH2A gene. Stem Cell Res. 2020;50:102129 pubmed publisher
Kilmister E, Patel J, van Schaijik B, Bockett N, Brasch H, Paterson E, et al. Cancer Stem Cell Subpopulations Are Present Within Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma. Front Oncol. 2020;10:1091 pubmed publisher
Baines K, Hillier D, Haddad F, Rajakumar N, Schmid S, Renaud S. Maternal Immune Activation Alters Fetal Brain Development and Enhances Proliferation of Neural Precursor Cells in Rats. Front Immunol. 2020;11:1145 pubmed publisher
Munro M, Peng L, Wickremesekera S, Tan S. Colon adenocarcinoma-derived cells that express induced-pluripotent stem cell markers possess stem cell function. PLoS ONE. 2020;15:e0232934 pubmed publisher
Yoganandarajah V, Patel J, van Schaijik B, Bockett N, Brasch H, Paterson E, et al. Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma. Cells. 2020;9: pubmed publisher
Dash S, Brastrom L, Patel S, Scott C, Slusarski D, Lachke S. The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Hum Mol Genet. 2020;29:591-604 pubmed publisher
Friman E, Deluz C, Meireles Filho A, Govindan S, Gardeux V, Deplancke B, et al. Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle. elife. 2019;8: pubmed publisher
McLenachan S, Zhang D, Zhang X, Chen S, Lamey T, Thompson J, et al. Generation of two induced pluripotent stem cell lines from a patient with dominant PRPF31 mutation and a related non-penetrant carrier. Stem Cell Res. 2019;34:101357 pubmed publisher
Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, et al. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017;19:341-351 pubmed publisher
Míguez D. A Branching Process to Characterize the Dynamics of Stem Cell Differentiation. Sci Rep. 2015;5:13265 pubmed publisher
product information
Product Type :
Antibody
Product Name :
SOX2 Polyclonal Antibody
Catalog # :
48-1400
Quantity :
100 µg
Price :
US 450
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 2-3 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
Immunogen :
Synthetic peptide derived from the N-terminal region of the human SOX2 protein
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2-3 µg/mL, Immunohistochemistry (Paraffin): 1:20, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
Aliases :
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA