LYVE1 Monoclonal Antibody (ALY7), eFluor™ 450, eBioscience | Invitrogen 48-0443-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LYVE1 Monoclonal Antibody (ALY7), eFluor™ 450, eBioscience

catalog :

48-0443-82

quantity :

100 µg

price :

US 424

clonality :

monoclonal

host :

rat

conjugate :

eFluor 450

clone name :

ALY7

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 3g, s4b	Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, et al. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nat Commun. 2022;13:2176 pubmed publisher
	Siret C, van Lessen M, Bavais J, Jeong H, Reddy Samawar S, Kapupara K, et al. Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain. Nat Commun. 2022;13:7366 pubmed publisher
	Biswas A, Singh S, Kartha G, Khurana S. Immuno-localization of definitive hematopoietic stem cells in the vascular niche of mouse fetal liver. STAR Protoc. 2022;3:101580 pubmed publisher
	Kobayashi D, Sugiura Y, Umemoto E, Takeda A, Ueta H, Hayasaka H, et al. Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes. Front Immunol. 2021;12:786595 pubmed publisher
	Zhang D, Huang J, Sun X, Chen H, Huang S, Yang J, et al. Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway. Nat Commun. 2021;12:4391 pubmed publisher
	Nishina T, Deguchi Y, Ohshima D, Takeda W, Ohtsuka M, Shichino S, et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021;12:2281 pubmed publisher
	Nguyen S, Ahn S, Greenberg J, Collaer B, Agnew D, Arora R, et al. Integrins mediate placental extracellular vesicle trafficking to lung and liver in vivo. Sci Rep. 2021;11:4217 pubmed publisher
	Alexander J, Seua A, Arroyo L, Ray P, Wangzhou A, Hei x3b2 L xfc ckemann L, et al. Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits. Theranostics. 2021;11:3109-3130 pubmed publisher
	Hofmann J, Gadjalova I, Mishra R, Ruland J, Keppler S. Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation. Front Immunol. 2020;11:599495 pubmed publisher
	Bolte A, Dutta A, Hurt M, Smirnov I, Kovacs M, McKee C, et al. Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat Commun. 2020;11:4524 pubmed publisher
	Shrestha S, Cho W, Stump B, Imani J, Lamattina A, Louis P, et al. FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020;26:75 pubmed publisher
	Chen J, Wang L, Xu H, Xing L, Zhuang Z, Zheng Y, et al. Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage. Nat Commun. 2020;11:3159 pubmed publisher
	Elham E, Wumaier R, Wang C, Luo X, Chen T, Zhong N. Anatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation. Med Hypotheses. 2020;143:109898 pubmed publisher
	Etzerodt A, Moulin M, Doktor T, Delfini M, Mossadegh Keller N, Bajenoff M, et al. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. J Exp Med. 2020;217: pubmed publisher

product information

Product Type :

Antibody

Product Name :

LYVE1 Monoclonal Antibody (ALY7), eFluor™ 450, eBioscience

Catalog # :

48-0443-82

Quantity :

100 µg

Price :

US 424

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Mouse

Clone :

ALY7

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 is a type I integral membrane glycoprotein. LYVE-1 is expressed primarily on lymphatic vessel endothelium and is likely to be involved in regulating the traffic of leucocytes and tumor cells to lymph nodes. The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. A number of molecules have been identified as markers for lymphatic endothelium which include LYVE1, PALE, VEGFR3, and podoplanin. Diseases associated with LYVE1 dysfunction includes Complete Androgen Insensitivity Syndrome.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

1200012G08Rik; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; CRSBP1; CRSBP-1; extra cellular link domain-containing 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; HAR; hyaluronic acid receptor; lymphatic endothelial hyaluronan receptor LYVE-1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronan receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1; LYVE-1; sLyve 1; sLyve1; soluble LYVE 1; soluble LYVE1; UNQ230/PRO263; XLKD1

more info or order :

Invitrogen product webpage