CD38 Monoclonal Antibody (HB7), eFluor 450, eBioscience | Invitrogen 48-0388-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD38 Monoclonal Antibody (HB7), eFluor 450, eBioscience

catalog :

48-0388-42

quantity :

100 Tests

price :

US 295.00

clonality :

monoclonal

host :

mouse

conjugate :

eFluor 450

clone name :

HB7

The same clone is also sold as:

Santa Cruz Biotechnology: sc-18858
BD Biosciences: 342371, 347680, 335808, 335790, 340676, 340677, 562665, 653314, 345806, 347687, 646852, 340926, 340927, 646851, 340439
BioLegend: 356605, 356643, 356606, 356617, 356630, 356602, 356641, 356610, 356612, 356624, 356644, 356629, 356633, 356627, 356609, 356637, 356645, 356632, 356639, 356619, 356601, 356620, 356618, 356614, 356642, 356604, 356616, 356634, 356626, 356628, 356623, 356615, 356622, 356607, 356603, 356631, 356625, 356611, 356613, 356621, 356635, 356608
OriGene: DDX0161P-100

reactivity :

human

application :

flow cytometry

citations: 10

Reference
Volodarsky I, Shimoni S, Haberman D, Mirkin V, Fabrikant Y, Yoskovich Mashriki T, et al. Circulating Regulatory B-Lymphocytes in Patients with Acute Myocardial Infarction: A Pilot Study. J Cardiovasc Dev Dis. 2022;10: pubmed publisher
Shukla S, Ying W, Gray F, Yao Y, Simes M, Zhao Q, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021;17:784-793 pubmed publisher
WILLIAMS D, Greenwell Wild T, Brenchley L, Dutzan N, Overmiller A, Sawaya A, et al. Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell. 2021;184:4090-4104.e15 pubmed publisher
Caeser R, Di Re M, Krupka J, Gao J, Lara Chica M, Dias J, et al. Genetic modification of primary human B cells to model high-grade lymphoma. Nat Commun. 2019;10:4543 pubmed publisher
Ezponda T, Dupéré Richer D, Will C, Small E, Varghese N, Patel T, et al. UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition. Cell Rep. 2017;21:628-640 pubmed publisher
Dendrou C, Cortes A, Shipman L, Evans H, Attfield K, Jostins L, et al. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med. 2016;8:363ra149 pubmed
Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R. CD38 is constitutively expressed in the nucleus of human hematopoietic cells. J Cell Biochem. 2008;105:905-12 pubmed publisher
Goldmacher V, Bourret L, Levine B, Rasmussen R, Pourshadi M, Lambert J, et al. Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma. Blood. 1994;84:3017-25 pubmed
Jackson D, Bell J. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol. 1990;144:2811-5 pubmed
Terstappen L, Huang S, Safford M, Lansdorp P, Loken M. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells. Blood. 1991;77:1218-27 pubmed

product information

Product Type :

Antibody

Product Name :

CD38 Monoclonal Antibody (HB7), eFluor 450, eBioscience

Catalog # :

48-0388-42

Quantity :

100 Tests

Price :

US 295.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.06 ug)/test

Species :

Human

Clone :

HB7

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.06 ug)/test

Aliases :

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10