product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD34 Monoclonal Antibody (RAM34), eFluor™ 450, eBioscience
catalog :
48-0341-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
eFluor 450
clone name :
RAM34
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 219
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:50; loading ...
Tillie R, Theelen T, van Kuijk K, Temmerman L, de Bruijn J, Gijbels M, et al. A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis. Cells. 2021;10: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
Lüscher Firzlaff J, Chatain N, Kuo C, Braunschweig T, Bochynska A, Ullius A, et al. Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l. Sci Rep. 2019;9:8262 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig 2a
Zhang Y, Xia F, Liu X, Yu Z, Xie L, Liu L, et al. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/?-catenin/CCND1 signaling. J Clin Invest. 2018;128:1737-1751 pubmed publisher
  • flow cytometry; mouse; fig s4
Cañete A, Carmona R, Ariza L, Sanchez M, Rojas A, Muñoz Chápuli R. A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice. Haematologica. 2017;102:647-655 pubmed publisher
  • flow cytometry; mouse; loading ...
Costa D, Principi E, Lazzarini E, Descalzi F, Cancedda R, Castagnola P, et al. LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment. J Cell Physiol. 2017;232:3077-3087 pubmed publisher
  • flow cytometry; mouse; fig 3d
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
  • flow cytometry; mouse; fig 1
Terashima A, Okamoto K, Nakashima T, Akira S, Ikuta K, Takayanagi H. Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency. Immunity. 2016;44:1434-43 pubmed publisher
Tarazi S, Aguilera Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell. 2022;185:3290-3306.e25 pubmed publisher
Wang Y, Huang Y, Cai W, Tao Q. Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature. Exp Ther Med. 2022;24:593 pubmed publisher
Klockner I, Schütt C, Gerhardt T, Boettger T, Braun T. Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. Nat Commun. 2022;13:3180 pubmed publisher
Yu L, Lin Y, Yan M, Li T, Wu E, Zimmel K, et al. Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine. Development. 2022;149: pubmed publisher
Flora P, Li M, Galbo P, Astorkia M, Zheng D, Ezhkova E. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration. PLoS Genet. 2021;17:e1009948 pubmed publisher
Hinterbrandner M, Rubino V, Stoll C, Forster S, Schnüriger N, Radpour R, et al. Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells. JCI Insight. 2021;6: pubmed publisher
Cohen C, Le Goff O, Soysouvanh F, Vasseur F, Tanou M, Nguyen C, et al. Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1. EMBO Mol Med. 2021;13:e14146 pubmed publisher
Tang H, Zhang P, Zeng L, Zhao Y, Xie L, Chen B. Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat. Stem Cell Res Ther. 2021;12:409 pubmed publisher
Yamada S, Yassin M, Schwarz T, Hansmann J, Mustafa K. Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor. J Tissue Eng. 2021;12:20417314211019375 pubmed publisher
Gao J, Yuan J, Liu Q, Wang Y, Wang H, Chen Y, et al. Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury. Stem Cell Res Ther. 2021;12:355 pubmed publisher
Ribas Latre A, Santos R, Fekry B, Tamim Y, Shivshankar S, Mohamed A, et al. Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue. Nat Commun. 2021;12:3482 pubmed publisher
Baltanás F, Mucientes Valdivieso C, Lorenzo Martín L, Fernández Parejo N, García Navas R, Segrelles C, et al. Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis. Cancers (Basel). 2021;13: pubmed publisher
Sávio Silva C, Soinski Sousa P, Simplício Filho A, Bastos R, Beyerstedt S, Rangel E. Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity. Int J Mol Sci. 2021;22: pubmed publisher
Li Y, Sun X, Zhang X, Zhou H, Wang D, Xia Y, et al. Functional damage of endothelial progenitor cells is attenuated by 14-3-3-n through inhibition of mitochondrial injury and oxidative stress. Cell Biol Int. 2021;45:839-848 pubmed publisher
Declercq M, de Zeeuw P, Conchinha N, Geldhof V, Ramalho A, Garc xed a Caballero M, et al. Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype. Eur Respir J. 2021;57: pubmed publisher
Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, et al. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020;11:827 pubmed publisher
Kondo J, Huh W, Franklin J, Heinrich M, Rubin B, Coffey R. A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin. J Pathol. 2020;252:441-450 pubmed publisher
Sanches B, Maldarine J, Tamarindo G, Da Silva A, Lima M, Rahal P, et al. Explant culture: A relevant tool for the study of telocytes. Cell Biol Int. 2020;44:2395-2408 pubmed publisher
Li G, Tang X, Zhang S, Jin M, Wang M, Deng Z, et al. SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. EMBO J. 2020;:e104365 pubmed publisher
Liu J, Qiu P, Qin J, Wu X, Wang X, Yang X, et al. Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. Stem Cells. 2020;38:1307-1320 pubmed publisher
Wilkes M, Siva K, Chen J, Varetti G, Youn M, Chae H, et al. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Nat Commun. 2020;11:3344 pubmed publisher
Niethamer T, Stabler C, Leach J, Zepp J, Morley M, Babu A, et al. Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury. elife. 2020;9: pubmed publisher
Chen L, Singh S, Muller G, Bornstein S, Kanczkowski W. Transcriptional Analysis of Sepsis-Induced Activation and Damage of the Adrenal Endothelial Microvascular Cells. Front Endocrinol (Lausanne). 2019;10:944 pubmed publisher
Li J, Wang T, Li C, Wang Z, Wang P, Zheng L. Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model. J Cell Physiol. 2020;235:6754-6766 pubmed publisher
Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020;130:1377-1391 pubmed publisher
Kang S, Long K, Wang S, Sada A, Tumbar T. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin. Stem Cell Reports. 2020;14:34-48 pubmed publisher
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, et al. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020;217: pubmed publisher
Durham E, Howie R, Larson N, LaRue A, Cray J. Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion. Stem Cell Res. 2019;40:101528 pubmed publisher
Kiss M, Ozsvar Kozma M, Porsch F, Göderle L, Papac Milicevic N, Bartolini Gritti B, et al. Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production. Front Immunol. 2019;10:1607 pubmed publisher
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed publisher
Meln I, Wolff G, Gajek T, Koddebusch J, Lerch S, Harbrecht L, et al. Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth. Mol Metab. 2019;24:139-148 pubmed publisher
Seneviratne A, Xu M, Henao J, Fajardo V, Hao Z, Voisin V, et al. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Cell Stem Cell. 2019;24:621-636.e16 pubmed publisher
Camps J, Grosemans H, Gijsbers R, Maes C, Sampaolesi M. Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells. Int J Mol Sci. 2019;20: pubmed publisher
Soukup A, Zheng Y, Mehta C, Wu J, Liu P, Cao M, et al. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019;129:1180-1192 pubmed publisher
Cervantes Villagrana R, Color Aparicio V, Reyes Cruz G, Vazquez Prado J. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;13:179-191 pubmed publisher
Karatepe K, Zhu H, Zhang X, Guo R, Kambara H, Loison F, et al. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018;11:1092-1105 pubmed publisher
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Nguyen M, Cohen I, Kumar V, Xu Z, Bar C, Dauber Decker K, et al. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018;9:2333 pubmed publisher
Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, et al. The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. elife. 2018;7: pubmed publisher
Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, et al. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. Cell Stem Cell. 2018;22:713-725.e8 pubmed publisher
Nagase R, Inoue D, Pastore A, Fujino T, Hou H, Yamasaki N, et al. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 2018;215:1729-1747 pubmed publisher
Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung T, et al. p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. 2018;37: pubmed publisher
Castel D, Baghdadi M, Mella S, Gayraud Morel B, Marty V, Cavaillé J, et al. Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression. Sci Rep. 2018;8:4208 pubmed publisher
Li Z, Zhang S, Cao L, Li W, Ye Y, Shi Z, et al. Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43. Exp Ther Med. 2018;15:1847-1854 pubmed publisher
Tosic M, Allen A, Willmann D, Lepper C, Kim J, Duteil D, et al. Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells. Nat Commun. 2018;9:366 pubmed publisher
Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, et al. Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. J Biol Chem. 2018;293:1596-1609 pubmed publisher
Yang J, Joshi S, Wang Q, Li P, Wang H, Xiong Y, et al. 14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature. Cell Biosci. 2017;7:58 pubmed publisher
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Delás M, Sabin L, Dolzhenko E, Knott S, Munera Maravilla E, Jackson B, et al. lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. elife. 2017;6: pubmed publisher
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Wang Y, Wang W, Wang X, Wang Y, Wang J, Fu Q, et al. Tissue-engineered sling with adipose-derived stem cells under static mechanical strain. Exp Ther Med. 2017;14:1337-1342 pubmed publisher
Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed publisher
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Fenouille N, Bassil C, Ben Sahra I, Benajiba L, Alexe G, Ramos A, et al. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med. 2017;23:301-313 pubmed publisher
Chiche A, Le Roux I, von Joest M, Sakai H, Aguín S, Cazin C, et al. Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle. Cell Stem Cell. 2017;20:407-414.e4 pubmed publisher
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
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van de Glind G, Out Luiting J, Rebel H, Tensen C, de Gruijl F. Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors. Oncotarget. 2016;7:52085-52094 pubmed publisher
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Wang B, Zhao L, Fish M, Logan C, Nusse R. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015;524:180-5 pubmed publisher
Stitelman D, Brazelton T, Bora A, Traas J, Merianos D, Limberis M, et al. Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9. Mol Ther Methods Clin Dev. 2014;1:14040 pubmed publisher
Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher
Stitelman D, Brazelton T, Endo M, Bora A, Traas J, Zoltick P, et al. Life-Long Transgene Expression in Skeletal Muscle Without Transduction of Satellite Cells Following Embryonic Myogenic Progenitor Transduction by Lentivirus Administered in Utero. Stem Cells Dev. 2015;24:1878-87 pubmed publisher
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Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, et al. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death Dis. 2014;5:e1567 pubmed publisher
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Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, et al. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network. Cell Rep. 2014;8:1328-38 pubmed publisher
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Siu K, Xu Y, Swartz K, Bhattacharyya M, Gurbuxani S, Hua Y, et al. Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014;34:3244-58 pubmed publisher
van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-41 pubmed publisher
Cosgrove B, Gilbert P, Porpiglia E, Mourkioti F, Lee S, Corbel S, et al. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med. 2014;20:255-64 pubmed publisher
Hittinger M, Czyz Z, Huesemann Y, Maneck M, Botteron C, Kaeufl S, et al. Molecular profiling of single Sca-1+/CD34+,- cells--the putative murine lung stem cells. PLoS ONE. 2013;8:e83917 pubmed publisher
Fornaro M, Hinken A, Needle S, Hu E, Trendelenburg A, Mayer A, et al. Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. Am J Physiol Endocrinol Metab. 2014;306:E150-6 pubmed publisher
Peng Y, Levine C, Zahid S, Wilson E, Joyner A. Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration. Proc Natl Acad Sci U S A. 2013;110:20611-6 pubmed publisher
Alessio A, Beltrame M, Nascimento M, Vicente C, de Godoy J, Silva J, et al. Circulating progenitor and mature endothelial cells in deep vein thrombosis. Int J Med Sci. 2013;10:1746-54 pubmed publisher
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Singh R, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, et al. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013;121:5158-66 pubmed publisher
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Park S, Wamsley H, Bae K, Hu Z, Li X, Choe S, et al. Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS ONE. 2013;8:e59675 pubmed publisher
Saito Y, Kaneda K, Suekane A, Ichihara E, Nakahata S, Yamakawa N, et al. Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia. 2013;27:1637-49 pubmed publisher
Zhu B, Smith J, Yarmush M, Nahmias Y, Kirby B, Murthy S. Microfluidic enrichment of mouse epidermal stem cells and validation of stem cell proliferation in vitro. Tissue Eng Part C Methods. 2013;19:765-73 pubmed publisher
Jeannet R, Cai Q, Liu H, Vu H, Kuo Y. Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal. Stem Cells. 2013;31:560-71 pubmed publisher
Franke K, Kalucka J, Mamlouk S, Singh R, Muschter A, Weidemann A, et al. HIF-1? is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2?-induced excessive erythropoiesis. Blood. 2013;121:1436-45 pubmed publisher
Li J, Zhao Z, Carter C, Ehrlich L, Bedford M, Richie E. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 2013;190:597-604 pubmed publisher
Liu G, Hu X, Sun B, Yang T, Shi J, Zhang L, et al. Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood. 2013;121:519-29 pubmed publisher
Takahashi H, Haraguchi N, Nishikawa S, Miyazaki S, Suzuki Y, Mizushima T, et al. Biological and clinical availability of adipose-derived stem cells for pelvic dead space repair. Stem Cells Transl Med. 2012;1:803-10 pubmed publisher
Bai X, Trowbridge J, Riley E, Lee J, DiBiase A, KAARTINEN V, et al. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013;373:422-30 pubmed publisher
Toyama H, Arai F, Hosokawa K, Ikushima Y, Suda T. N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs. Biochem Biophys Res Commun. 2012;428:354-9 pubmed publisher
Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
Dahlin J, Feinstein R, Cui Y, Heyman B, Hallgren J. CD11c+ cells are required for antigen-induced increase of mast cells in the lung. J Immunol. 2012;189:3869-77 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD34 Monoclonal Antibody (RAM34), eFluor™ 450, eBioscience
Catalog # :
48-0341-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test
Species :
Mouse
Clone :
RAM34
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA