CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), eFluor 450, eBioscience | Invitrogen 48-0212-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), eFluor 450, eBioscience

catalog :

48-0212-82

quantity :

100 ug

price :

US 375.00

clonality :

monoclonal

host :

rat

conjugate :

eFluor 450

clone name :

eBio4E3 (4E3)

reactivity :

mouse

application :

flow cytometry

citations: 17

Reference
McCorkell K, Jayachandran N, Cully M, Freund Brown J, Weinkopff T, Monslow J, et al. Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Lee H, Celhar T, Fairhurst A. Assessing Lupus-Like Disease in Murine Model Systems. Curr Protoc. 2021;1:e272 pubmed publisher
Graham J, Yoachim S, Gould K. Estrogen Receptor Alpha Signaling Is Responsible for the Female Sex Bias in the Loss of Tolerance and Immune Cell Activation Induced by the Lupus Susceptibility Locus Sle1b. Front Immunol. 2020;11:582214 pubmed publisher
Yewdell W, Kim Y, Chowdhury P, Lau C, Smolkin R, Belcheva K, et al. A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization. Immunity. 2020;53:952-970.e11 pubmed publisher
Hong J, Reynoso G, Andhey P, Swain A, Turner J, Boon A, et al. An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Cell Rep Med. 2020;1: pubmed publisher
Fenninger F, Han J, Stanwood S, Nohara L, Arora H, Choi K, et al. Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction. Front Immunol. 2019;10:2473 pubmed publisher
Demeyer A, Skordos I, Driege Y, Kreike M, Hochepied T, Baens M, et al. MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner. Front Immunol. 2019;10:1898 pubmed publisher
Russell Knode L, Naradikian M, Myles A, Scholz J, Hao Y, Liu D, et al. Age-Associated B Cells Express a Diverse Repertoire of VH and VÎº Genes with Somatic Hypermutation. J Immunol. 2017;198:1921-1927 pubmed publisher
Qu X, Li J, Baldwin H. Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice. Biochem Biophys Res Commun. 2016;470:613-619 pubmed publisher
Huang L, Kong Y, Wang J, Sun J, Shi Q, Qiu Y. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway. Mol Med Rep. 2015;12:4187-4195 pubmed publisher
Peterson L, Pennington L, Shaw L, Brown M, Treacy E, Friend S, et al. SLAP deficiency decreases dsDNA autoantibody production. Clin Immunol. 2014;150:201-9 pubmed publisher
Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar Colucci S, Huang K, et al. Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J Neurosci. 2013;33:12970-81 pubmed publisher
Turner J, Narang P, Coles M, Mountford A. Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host. PLoS Pathog. 2012;8:e1003063 pubmed publisher
Bryan M, Norris K. Genetic immunization converts the trypanosoma cruzi B-Cell mitogen proline racemase to an effective immunogen. Infect Immun. 2010;78:810-22 pubmed publisher
You Y, Zhao H, Wang Y, Carter R. Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone. J Immunol. 2009;182:7343-7 pubmed publisher
Kozono Y, Abe R, Kozono H, Kelly R, Azuma T, Holers V. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J Immunol. 1998;160:1565-72 pubmed
Martin B, Weis J. Murine macrophages lack expression of the Cr2-145 (CR2) and Cr2-190 (CR1) gene products. Eur J Immunol. 1993;23:3037-42 pubmed

product information

Product Type :

Antibody

Product Name :

CD21/CD35 Monoclonal Antibody (eBio4E3 (4E3)), eFluor 450, eBioscience

Catalog # :

48-0212-82

Quantity :

100 ug

Price :

US 375.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

eBio4E3 (4E3)

Isotype :

IgG2a, lambda

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 1; complement receptor type 2; CR; Cr1; Cr-1; Cr2; Cr-2; CVID7; EBV receptor; Epstein-Barr virus receptor; expressed in B lymphocytes; SLEB9