CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), APC-eFluor 780, eBioscience | Invitrogen 47-1379-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), APC-eFluor 780, eBioscience

catalog :

47-1379-41

quantity :

25 Tests

price :

US 189.00

clonality :

monoclonal

host :

mouse

conjugate :

APC/efluor 780

clone name :

4B4 (4B4-1)

reactivity :

human

application :

flow cytometry

citations: 3

Reference
St Paul M, Saibil S, Kates M, Han S, Lien S, Laister R, et al. Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy. Cell Rep Med. 2024;5:101465 pubmed publisher
Want M, Konstorum A, Huang R, Jain V, Matsueda S, Tsuji T, et al. Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer. Oncoimmunology. 2019;8:e1586042 pubmed publisher
Guan C, Li Q, Song X, Xu W, Li L, Xu A. Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2. Oxid Med Cell Longev. 2017;2017:9303054 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD137 (4-1BB) Monoclonal Antibody (4B4 (4B4-1)), APC-eFluor 780, eBioscience

Catalog # :

47-1379-41

Quantity :

25 Tests

Price :

US 189.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.25 ug)/test

Species :

Human

Clone :

4B4 (4B4-1)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.25 ug)/test

Aliases :

4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9