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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD117 (c-Kit) Monoclonal Antibody (ACK2), APC-eFluor 780, eBioscience™
catalog :
47-1172-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
APC/efluor 780
clone name :
ACK2
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 95
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s4a
Brown C, Gudjonson H, Pritykin Y, Deep D, Lavallée V, Mendoza A, et al. Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 2019;179:846-863.e24 pubmed publisher
  • flow cytometry; mouse; fig s2d
Christ A, Günther P, Lauterbach M, Duewell P, Biswas D, Pelka K, et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018;172:162-175.e14 pubmed publisher
  • flow cytometry; mouse; fig 3c
Astuti Y, Kramer A, Blake A, Blazar B, Tolar J, Taisto M, et al. A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing. Stem Cell Reports. 2017;8:177-190 pubmed publisher
  • flow cytometry; mouse; fig 1
Wu X, Satpathy A, Kc W, Liu P, Murphy T, Murphy K. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PLoS ONE. 2013;8:e64800 pubmed publisher
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore A, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017;46:818-834.e4 pubmed publisher
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed publisher
Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed publisher
Zhou Y, Copeland B, Otto Duessel M, He M, Markel S, Synold T, et al. Low Testosterone Alters the Activity of Mouse Prostate Stem Cells. Prostate. 2017;77:530-541 pubmed publisher
Weng L, Hu X, Kumar B, García M, Todorov I, Jung X, et al. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Sci Rep. 2016;6:38632 pubmed publisher
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher
Puram R, Kowalczyk M, de Boer C, Schneider R, Miller P, McConkey M, et al. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell. 2016;165:303-16 pubmed publisher
Karamitros D, Patmanidi A, Kotantaki P, Potocnik A, Bähr Ivacevic T, Benes V, et al. Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015;142:70-81 pubmed publisher
Ebert S, Becker M, Lemmermann N, Büttner J, Michel A, Taube C, et al. Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs. PLoS Pathog. 2014;10:e1004100 pubmed publisher
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun K, et al. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014;211:209-15 pubmed publisher
Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, et al. Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. Am J Pathol. 2014;184:122-32 pubmed publisher
Li X, Xue H, Kang Q, Sun H, Yang S, Zhang G, et al. Alterations of the interstitial cells of Cajal and the microstructure of the gastrointestinal tract in KIT distal kinase mutant mice. Cell Tissue Res. 2014;355:49-58 pubmed publisher
Langford Smith K, Sandiford Z, Langford Smith A, Wilkinson F, Jones S, Wraith J, et al. Signal one and two blockade are both critical for non-myeloablative murine HSCT across a major histocompatibility complex barrier. PLoS ONE. 2013;8:e77632 pubmed publisher
Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed publisher
Wu C, Lin Y, Gao J, Winston J, Cheng L, Shi X. Are interstitial cells of Cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction?. PLoS ONE. 2013;8:e76222 pubmed publisher
Yoshida A, Kato J, Nakamae I, Yoneda Kato N. COP1 targets C/EBP? for degradation and induces acute myeloid leukemia via Trib1. Blood. 2013;122:1750-60 pubmed publisher
Xiang F, Lu X, Liu Y, Feng Q. Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury. Int J Cardiol. 2013;168:3486-94 pubmed publisher
Fiedler K, Kokai E, Bresch S, Brunner C. MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen. Am J Blood Res. 2013;3:124-40 pubmed
Michel A, Schuler A, Friedrich P, Döner F, Bopp T, Radsak M, et al. Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol. 2013;190:5534-44 pubmed publisher
Lee J, Kim S, Kwon Y, Kim B, So I. Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine. Cell Physiol Biochem. 2013;31:542-54 pubmed publisher
Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed publisher
Viret C, Cresson C, Broccardo C, Guerder S. Retroviral transduction of lineage antigen-negative ((Lin?) cells: a valuable alternative for the generation of T cell receptor (TCR) retrogenic mice. J Immunol Methods. 2012;384:103-10 pubmed publisher
Hashitani H, Mitsui R, Shimizu Y, Higashi R, Nakamura K. Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder. Br J Pharmacol. 2012;167:1723-36 pubmed publisher
Smith K, Harcus Y, Garbi N, Hämmerling G, MacDonald A, Maizels R. Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infect Immun. 2012;80:3481-9 pubmed publisher
Tashiro K, Omori M, Kawabata K, Hirata N, Yamaguchi T, Sakurai F, et al. Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation. Stem Cells Dev. 2012;21:3381-90 pubmed publisher
Kim B, Chang I, Choi S, Jun J, Jeon J, Xu W, et al. Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cell Physiol Biochem. 2012;29:501-10 pubmed publisher
Ishii K, Kanatsu Shinohara M, Toyokuni S, Shinohara T. FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development. 2012;139:1734-43 pubmed publisher
He X, Yang W, Wen X, Tang D, Xiao L, Han J, et al. Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence. Cells Tissues Organs. 2012;196:175-88 pubmed publisher
Treviño Villarreal J, Cotanche D, Sepúlveda R, Bortoni M, Manneberg O, Udagawa T, et al. Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma. J Histochem Cytochem. 2011;59:1060-75 pubmed publisher
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed publisher
Tashiro K, Kawabata K, Omori M, Yamaguchi T, Sakurai F, Katayama K, et al. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res. 2012;8:300-11 pubmed publisher
Lowie B, Wang X, White E, Huizinga J. On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2011;301:G835-45 pubmed publisher
Glotzbach J, Januszyk M, Vial I, Wong V, Gelbard A, Kalisky T, et al. An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS ONE. 2011;6:e21211 pubmed publisher
Ding X, Lin Q, Ensenat Waser R, Rose John S, Zenke M. Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells. Stem Cells Dev. 2012;21:121-32 pubmed publisher
Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, et al. Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat ?-thalassemia. Mol Ther. 2011;19:1273-86 pubmed publisher
Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang G, et al. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation. Biochem Biophys Res Commun. 2011;406:529-33 pubmed publisher
Zhou Y, He Y, Chen C, Ji J, Niu J, Wang H, et al. Time-specific blockade of PDGFR with Imatinib (Glivec®) causes cataract and disruption of lens fiber cells in neonatal mice. Virchows Arch. 2011;458:349-56 pubmed publisher
Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D. Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010;137:3941-52 pubmed publisher
Huang Y, Li F, Tong W, Zhang A, He Y, Fu T, et al. Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of Cajal via phosphorylation of AKT protein kinase. Tohoku J Exp Med. 2010;221:125-32 pubmed
Dixon R, Ramsey K, Schripsema J, Sanders K, Ward S. Time-dependent disruption of oviduct pacemaker cells by Chlamydia infection in mice. Biol Reprod. 2010;83:244-53 pubmed publisher
Liu D, Wang F, Zou Z, Dong S, Wang J, Ran X, et al. Bone marrow derivation of interstitial cells of cajal in small intestine following intestinal injury. J Biomed Biotechnol. 2010;2010:164986 pubmed publisher
Tong W, Jia H, Zhang L, Li C, Ridolfi T, Liu B. Exogenous stem cell factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway. Scand J Gastroenterol. 2010;45:844-51 pubmed publisher
Tharayil V, Wouters M, Stanich J, Roeder J, Lei S, Beyder A, et al. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil. 2010;22:462-9, e109-10 pubmed publisher
Onai N, Manz M, Schmid M. Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. Methods Mol Biol. 2010;595:195-203 pubmed publisher
Ueda T, Yamada T, Hokuto D, Koyama F, Kasuda S, Kanehiro H, et al. Generation of functional gut-like organ from mouse induced pluripotent stem cells. Biochem Biophys Res Commun. 2010;391:38-42 pubmed publisher
Han J, SHEN W, Jiang Y, Yu B, He Y, Li N, et al. Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life. Histochem Cell Biol. 2010;133:163-75 pubmed publisher
Gaudenzio N, Espagnolle N, Mars L, Liblau R, Valitutti S, Espinosa E. Cell-cell cooperation at the T helper cell/mast cell immunological synapse. Blood. 2009;114:4979-88 pubmed publisher
Wouters M, Roeder J, Tharayil V, Stanich J, Strege P, Lei S, et al. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009;284:21177-84 pubmed publisher
Astrakhan A, Ochs H, Rawlings D. Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol. 2009;182:7370-80 pubmed publisher
Cridland S, Keys J, Papathanasiou P, Perkins A. Indian hedgehog supports definitive erythropoiesis. Blood Cells Mol Dis. 2009;43:149-55 pubmed publisher
Ozao Choy J, Ma G, Kao J, Wang G, Meseck M, Sung M, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 2009;69:2514-22 pubmed publisher
Velaga S, Herbrand H, Friedrichsen M, Jiong T, Dorsch M, Hoffmann M, et al. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol. 2009;182:2610-9 pubmed publisher
Mei F, Guo S, He Y, Zhu J, Zhou D, Niu J, et al. Apoptosis of interstitial cells of Cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult guinea pigs. Virchows Arch. 2009;454:401-9 pubmed publisher
Yu B, Han J, He Y, Guo S, Li S, Mei F. Immunohistochemical study of CD44 immunopositive cells in the muscular layers of the gastrointestinal tract in adult guinea pigs and mice. Acta Histochem. 2009;111:382-90 pubmed publisher
Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature. 2009;457:892-5 pubmed publisher
Erler J, Bennewith K, Cox T, Lang G, Bird D, Koong A, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 2009;15:35-44 pubmed publisher
Babbe H, McMenamin J, Hobeika E, Wang J, Rodig S, Reth M, et al. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol. 2009;182:347-60 pubmed
Mei F, Zhu J, Guo S, Zhou D, Han J, Yu B, et al. An age-dependent proliferation is involved in the postnatal development of interstitial cells of Cajal in the small intestine of mice. Histochem Cell Biol. 2009;131:43-53 pubmed publisher
Wallace G, Lapidos K, Kenik J, McNally E. Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy. Am J Pathol. 2008;173:792-802 pubmed publisher
Konuma N, Wakabayashi K, Matsumoto T, Kusumi Y, Masuko T, Iribe Y, et al. Mouse embryonic stem cells give rise to gut-like morphogenesis, including intestinal stem cells, in the embryoid body model. Stem Cells Dev. 2009;18:113-26 pubmed publisher
Huang Y, Mei F, Yu B, Zhang H, Han J, Jiang Z, et al. Distribution of the interstitial Cajal-like cells in the gallbladder and extrahepatic biliary duct of the guinea-pig. Acta Histochem. 2009;111:157-65 pubmed publisher
Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed publisher
Ullrich E, Bonmort M, Mignot G, Jacobs B, Bosisio D, Sozzani S, et al. Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. J Immunol. 2008;180:7887-97 pubmed
Gore B, Wong K, Tessier Lavigne M. Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target. Neuron. 2008;57:501-10 pubmed publisher
Nakai N, Ishikawa T, Nishitani A, Liu N, Shincho M, Hao H, et al. A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J Pathol. 2008;214:302-11 pubmed
Czechowicz A, Kraft D, Weissman I, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 2007;318:1296-9 pubmed
Edry E, Koralov S, Rajewsky K, Melamed D. Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement. J Immunol. 2007;179:6555-60 pubmed
Onai N, Obata Onai A, Schmid M, Ohteki T, Jarrossay D, Manz M. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007;8:1207-16 pubmed
Thomas F, Ismail R, Jiang J, Vanderhyden B. Kit ligand 2 promotes murine oocyte growth in vitro. Biol Reprod. 2008;78:167-75 pubmed
Chen H, ORDOG T, Chen J, YOUNG D, Bardsley M, Redelman D, et al. Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol Genomics. 2007;31:492-509 pubmed
Wouters M, Gibbons S, Roeder J, Distad M, Ou Y, Strege P, et al. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology. 2007;133:897-906 pubmed
Na Y, Baek H, Ahn S, Shin H, Chang I, Hwang J. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007;74:780-6 pubmed
Lu M, Glover C, Tien A, Humphries R, Piret J, Helgason C. Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality. Exp Hematol. 2007;35:1293-302 pubmed
Takaki M, Misawa H, Shimizu J, Kuniyasu H, Horiguchi K. Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor. Biochem Biophys Res Commun. 2007;359:354-9 pubmed
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten L, Ceredig R, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007;26:643-54 pubmed
Heib V, Becker M, Warger T, Rechtsteiner G, Tertilt C, Klein M, et al. Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice. Blood. 2007;110:946-53 pubmed
Mortaz E, Redegeld F, Dunsmore K, Odoms K, Wong H, Nijkamp F, et al. Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. Eur J Pharmacol. 2007;561:214-9 pubmed
Mei F, Yu B, Ma H, Zhang H, Zhou D. Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs. Virchows Arch. 2006;449:348-57 pubmed
Takaki M, Nakayama S, Misawa H, Nakagawa T, Kuniyasu H. In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells. Stem Cells. 2006;24:1414-22 pubmed
Kaplan R, Riba R, Zacharoulis S, Bramley A, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820-7 pubmed
Kim B, Lim H, Yang D, Jun J, Chang I, Park C, et al. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology. 2005;129:1504-17 pubmed
Tussiwand R, Onai N, Mazzucchelli L, Manz M. Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. J Immunol. 2005;175:3674-80 pubmed
Nakayama S, Ohya S, Liu H, Watanabe T, Furuzono S, Wang J, et al. Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility. J Cell Sci. 2005;118:4163-73 pubmed
Liu M, Geddis M, Wen Y, Setlik W, Gershon M. Expression and function of 5-HT4 receptors in the mouse enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2005;289:G1148-63 pubmed
Nakagawa T, Ueshima S, Fujii H, Nakajima Y, Takaki M. Different modulation of spontaneous activities by nitrergic inhibitory nerves between ileum and jejunum in W/Wv mutant mice. Auton Neurosci. 2005;119:25-35 pubmed
Terauchi A, Kobayashi D, Mashimo H. Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol Gastrointest Liver Physiol. 2005;289:G291-9 pubmed
Metzger R, Schuster T, Till H, Franke F, Dietz H. Cajal-like cells in the upper urinary tract: comparative study in various species. Pediatr Surg Int. 2005;21:169-74 pubmed
Liu H, Ohya S, Furuzono S, Wang J, Imaizumi Y, Nakayama S. Co-contribution of IP3R and Ca2+ influx pathways to pacemaker Ca2+ activity in stomach ICC. J Biol Rhythms. 2005;20:15-26 pubmed
Prasanth S, Ali S. Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. DNA Cell Biol. 2003;22:447-56 pubmed
Kim H, Shin H, Lee E. Morphological alterations in rat peritoneal mast cells by stem cell factor. Immunology. 1998;94:242-6 pubmed
Ismail R, Okawara Y, Fryer J, Vanderhyden B. Hormonal regulation of the ligand for c-kit in the rat ovary and its effects on spontaneous oocyte meiotic maturation. Mol Reprod Dev. 1996;43:458-69 pubmed
product information
Product Type :
Antibody
Product Name :
CD117 (c-Kit) Monoclonal Antibody (ACK2), APC-eFluor 780, eBioscience™
Catalog # :
47-1172-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
ACK2
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA