CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), APC-eFluor 780, eBioscience | Invitrogen 47-1071-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), APC-eFluor 780, eBioscience

catalog :

47-1071-82

quantity :

100 ug

price :

US 367.00

clonality :

monoclonal

host :

rat

conjugate :

APC/efluor 780

clone name :

eBio1D4B (1D4B)

reactivity :

mouse

application :

flow cytometry

citations: 16

Reference
Amer J, Salhab A, Snobar H, Alhabil Y. The immune and metabolic treatment approach of using testosterone on mice models of liver injury. Front Pharmacol. 2023;14:1219709 pubmed publisher
Ta A, Ricci Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, et al. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023;14:2035 pubmed publisher
Ren J, Han X, Lohner H, Hoyle R, Li J, Liang S, et al. P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer. Cancer Immunol Res. 2023;11:290-305 pubmed publisher
Denis M, Math xe9 D, Micoud M, Choffour P, Grasselly C, Matera E, et al. Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy. Front Immunol. 2022;13:1011943 pubmed publisher
Pan P, Zhu J, Rizvi A, Zhu X, Tanaka H, Dreyfus C. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. J Biol Chem. 2021;297:100873 pubmed publisher
Benjamin S, Hawley K, Vera Licona P, La Vake C, Cervantes J, Ruan Y, et al. Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation. BMC Immunol. 2021;22:32 pubmed publisher
Leventhal D, Sokolovska A, Li N, Plescia C, Kolodziej S, Gallant C, et al. Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nat Commun. 2020;11:2739 pubmed publisher
Cham L, Torrez Dulgeroff L, Tal M, Adomati T, Li F, Bhat H, et al. Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection. Cell Rep. 2020;31:107494 pubmed publisher
Salhab A, Amer J, Yinying L, Safadi R. 25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor. BMC Gastroenterol. 2020;20:102 pubmed publisher
Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, et al. CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity. Oncol Rep. 2019;41:2679-2688 pubmed publisher
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed publisher
Cheadle E, Lipowska Bhalla G, Dovedi S, Fagnano E, Klein C, Honeychurch J, et al. A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells. Leukemia. 2017;31:1611-1621 pubmed publisher
Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
Weber K, Schilling J. Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages. Int J Inflam. 2014;2014:154936 pubmed publisher
Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, et al. Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock. PLoS ONE. 2014;9:e110585 pubmed publisher
Wolint P, Betts M, Koup R, Oxenius A. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J Exp Med. 2004;199:925-36 pubmed

product information

Product Type :

Antibody

Product Name :

CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), APC-eFluor 780, eBioscience

Catalog # :

47-1071-82

Quantity :

100 ug

Price :

US 367.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1.0 ug/test

Species :

Mouse

Clone :

eBio1D4B (1D4B)

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1.0 ug/test

Aliases :

120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; LAMP1; LAMP-1; LAMPA; LGP120; LGP-120; LGPA; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B