CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), PerCP-eFluor™ 710, eBioscience | Invitrogen 46-9856-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), PerCP-eFluor™ 710, eBioscience

catalog :

46-9856-42

quantity :

100 Tests

price :

US 443.00

clonality :

monoclonal

host :

mouse

conjugate :

Percp/efluor 710

clone name :

15E2

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1d	Choi B, Suh C, Kim H, Sayeed H, Sohn S. The Correlation of CD206, CD209, and Disease Severity in Behçet's Disease with Arthritis. Mediators Inflamm. 2017;2017:7539529 pubmed publisher
	de Dios C, Abadin X, Roca Agujetas V, Jimenez Martinez M, Morales A, Trullas R, et al. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis. Transl Neurodegener. 2023;12:10 pubmed publisher
	Cui D, Franz A, Fillon S, Jannetti L, Isambert T, Fundel Clemens K, et al. High-Yield Human Induced Pluripotent Stem Cell-Derived Monocytes and Macrophages Are Functionally Comparable With Primary Cells. Front Cell Dev Biol. 2021;9:656867 pubmed publisher
	Du L, Chen X, Duan Z, Liu C, Zeng R, Chen Q, et al. MiR-146a negatively regulates dectin-1-induced inflammatory responses. Oncotarget. 2017;8:37355-37366 pubmed publisher
	Fischer M, Müller J, Spies Weisshart B, Grafe C, Kurzai O, Hünniger K, et al. Isoform localization of Dectin-1 regulates the signaling quality of anti-fungal immunity. Eur J Immunol. 2017;47:848-859 pubmed publisher
	El Awady A, Miles B, Scisci E, Kurago Z, Palani C, Arce R, et al. Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk. PLoS Pathog. 2015;10:e1004647 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), PerCP-eFluor™ 710, eBioscience

Catalog # :

46-9856-42

Quantity :

100 Tests

Price :

US 443.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human, Non-human primate

Clone :

15E2

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082

more info or order :

Invitrogen product webpage