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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-22 Monoclonal Antibody (22URTI), PerCP-eFluor 710, eBioscience
catalog :
46-7229-42
quantity :
100 Tests
price :
US 401
clonality :
monoclonal
host :
mouse
conjugate :
Percp/efluor 710
clone name :
22URTI
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1e
Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango M, Kaufmann S, et al. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell. 2019;: pubmed publisher
  • flow cytometry; human; fig 2d
Di Meglio P, Villanova F, Navarini A, Mylonas A, Tosi I, Nestle F, et al. Targeting CD8(+) T cells prevents psoriasis development. J Allergy Clin Immunol. 2016;138:274-276.e6 pubmed publisher
  • flow cytometry; human; fig 1
Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed publisher
  • flow cytometry; human
Bacher P, Kniemeyer O, Teutschbein J, Thön M, Vödisch M, Wartenberg D, et al. Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol. 2014;193:3332-43 pubmed publisher
Cassotta A, Goldstein J, Durini G, Jarrossay D, Baggi Menozzi F, Venditti M, et al. Broadly reactive human CD4+ T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire. Eur J Immunol. 2021;51:648-661 pubmed publisher
Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner H, Kuchroo V, et al. An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells. Nat Immunol. 2018;19:1126-1136 pubmed publisher
Chen X, Wang Y, Wang J, Wen J, Jia X, Wang X, et al. Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients. Oncol Lett. 2018;16:253-261 pubmed publisher
Yamada H, Haraguchi A, Sakuraba K, Okazaki K, Fukushi J, Mizu uchi H, et al. Th1 is the predominant helper T cell subset that produces GM-CSF in the joint of rheumatoid arthritis. RMD Open. 2017;3:e000487 pubmed publisher
Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, et al. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016;167:1067-1078.e16 pubmed publisher
Lindestam Arlehamn C, McKinney D, Carpenter C, Paul S, Rozot V, Makgotlho E, et al. A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. PLoS Pathog. 2016;12:e1005760 pubmed publisher
Fu D, Song X, Hu H, Sun M, Li Z, Tian Z. Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis. Mol Med Rep. 2016;13:4606-12 pubmed publisher
Carrega P, Loiacono F, Di Carlo E, Scaramuccia A, Mora M, Conte R, et al. NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures. Nat Commun. 2015;6:8280 pubmed publisher
Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed publisher
Plé C, Fan Y, Ait Yahia S, Vorng H, Everaere L, Chenivesse C, et al. Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. PLoS ONE. 2015;10:e0122372 pubmed publisher
Campillo Gimenez L, Casulli S, Dudoit Y, Seang S, Carcelain G, Lambert Niclot S, et al. Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment. J Allergy Clin Immunol. 2014;134:1142-52.e5 pubmed publisher
Zhang L, Wang T, Wang X, Du R, Zhang K, Liu X, et al. Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome. PLoS ONE. 2013;8:e71466 pubmed publisher
Bacher P, Kniemeyer O, Schonbrunn A, Sawitzki B, Assenmacher M, Rietschel E, et al. Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal Immunol. 2014;7:916-28 pubmed publisher
Prodger J, Hirbod T, Gray R, Kigozi G, Nalugoda F, Galiwango R, et al. HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-cell Function But Normal CD4 T-cell Numbers in the Foreskin. J Infect Dis. 2014;209:1185-94 pubmed publisher
Prodger J, Hirbod T, Kigozi G, Nalugoda F, Reynolds S, Galiwango R, et al. Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda. Mucosal Immunol. 2014;7:634-44 pubmed publisher
Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-? production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Ann Rheum Dis. 2014;73:1223-31 pubmed publisher
Nanzer A, Chambers E, Ryanna K, Richards D, Black C, Timms P, et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1?,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132:297-304.e3 pubmed publisher
Bacher P, Schink C, Teutschbein J, Kniemeyer O, Assenmacher M, Brakhage A, et al. Antigen-reactive T cell enrichment for direct, high-resolution analysis of the human naive and memory Th cell repertoire. J Immunol. 2013;190:3967-76 pubmed publisher
Qiu Y, Huang Y, Chen J, Qiao D, Zeng G, Cai J. Depletion of IL-22 during culture enhanced antigen-driven IFN-? production by CD4(+)T cells from patients with active TB. Immunol Lett. 2013;150:48-53 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Alonzo F, Kozhaya L, Rawlings S, Reyes Robles T, Dumont A, Myszka D, et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 2013;493:51-5 pubmed publisher
Lundgren A, Bhuiyan T, Novak D, Kaim J, Reske A, Lu Y, et al. Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country. Vaccine. 2012;30:3897-907 pubmed publisher
Zhang L, Li Y, Li Y, Qi L, Liu X, Yuan C, et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS ONE. 2012;7:e31000 pubmed publisher
Prodger J, Gray R, Kigozi G, Nalugoda F, Galiwango R, Hirbod T, et al. Foreskin T-cell subsets differ substantially from blood with respect to HIV co-receptor expression, inflammatory profile, and memory status. Mucosal Immunol. 2012;5:121-8 pubmed publisher
Liu B, Wei L, Meyerle C, Tuo J, Sen H, Li Z, et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med. 2011;9:1-12 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-22 Monoclonal Antibody (22URTI), PerCP-eFluor 710, eBioscience
Catalog # :
46-7229-42
Quantity :
100 Tests
Price :
US 401
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.015 µg)/test
Species :
Human
Clone :
22URTI
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons. IL-22 is produced mainly by activated T cells and NK cells. In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10. IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2. IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29. Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes. IL-22 has been described as an effector cytokine of the Th17 lineage. Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin. IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated. The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes. IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors. IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses. IL-22 is upregulated in activated T cells. IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.015 µg)/test
Aliases :
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA