IL-23 p19 Monoclonal Antibody (fc23cpg), PerCP-eFluor 710, eBioscience | Invitrogen 46-7023-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-23 p19 Monoclonal Antibody (fc23cpg), PerCP-eFluor 710, eBioscience

catalog :

46-7023-80

quantity :

25 ug

price :

US 202.00

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

fc23cpg

reactivity :

mouse

application :

flow cytometry

citations: 6

Reference
Yin Q, Sun L, Cai X, Lou F, Sun Y, Wang B, et al. Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication. J Invest Dermatol. 2022;142:2173-2183.e6 pubmed publisher
Mathur R, Alam M, Zhao X, Liao Y, Shen J, Morgan S, et al. Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. Mucosal Immunol. 2019;12:612-623 pubmed publisher
Hillyer P, Larche M, Bowman E, McClanahan T, de Waal Malefyt R, Schewitz L, et al. Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis. Rheumatology (Oxford). 2009;48:1581-9 pubmed publisher
Dennehy K, Willment J, Williams D, Brown G. Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur J Immunol. 2009;39:1379-86 pubmed publisher
Brentano F, Ospelt C, Stanczyk J, Gay R, Gay S, Kyburz D. Abundant expression of the interleukin (IL)23 subunit p19, but low levels of bioactive IL23 in the rheumatoid synovium: differential expression and Toll-like receptor-(TLR) dependent regulation of the IL23 subunits, p19 and p40, in rheumatoid arthrit. Ann Rheum Dis. 2009;68:143-50 pubmed publisher
Goriely S, Neurath M, Goldman M. How microorganisms tip the balance between interleukin-12 family members. Nat Rev Immunol. 2008;8:81-6 pubmed

product information

Product Type :

Antibody

Product Name :

IL-23 p19 Monoclonal Antibody (fc23cpg), PerCP-eFluor 710, eBioscience

Catalog # :

46-7023-80

Quantity :

25 ug

Price :

US 202.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 ug/test

Species :

Mouse

Clone :

fc23cpg

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN- . Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN- production by naive and memory T cells, as compared to IL-12.

Immunogen :

mouse IL-23p19 subunit

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test

Aliases :

il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798