ErbB3 (HER-3) Monoclonal Antibody (SGP1), PerCP-eFluor 710, eBioscience | Invitrogen 46-6555-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ErbB3 (HER-3) Monoclonal Antibody (SGP1), PerCP-eFluor 710, eBioscience

catalog :

46-6555-42

quantity :

100 Tests

price :

US 420.00

clonality :

monoclonal

host :

mouse

conjugate :

Percp/efluor 710

clone name :

SGP1

The same clone is also sold as:

Bio-Rad: MCA1410
Abcam: ab20162
Santa Cruz Biotechnology: sc-53279
OriGene: SM1444P

reactivity :

human

application :

flow cytometry

citations: 4

Reference
Bouyain S, Leahy D. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Protein Sci. 2007;16:654-61 pubmed
Offterdinger M, Schöfer C, Weipoltshammer K, Grunt T. c-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol. 2002;157:929-39 pubmed
Naidu R, Yadav M, Nair S, Kutty M. Expression of c-erbB3 protein in primary breast carcinomas. Br J Cancer. 1998;78:1385-90 pubmed
Rajkumar T, Gullick W. A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines. Br J Cancer. 1994;70:459-65 pubmed

product information

Product Type :

Antibody

Product Name :

ErbB3 (HER-3) Monoclonal Antibody (SGP1), PerCP-eFluor 710, eBioscience

Catalog # :

46-6555-42

Quantity :

100 Tests

Price :

US 420.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.125 ug)/test

Species :

Human

Clone :

SGP1

Isotype :

IgG1

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.125 ug)/test

Aliases :

avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; C76256; c-erbB3; c-erbB-3; C-errB-3; erb-b2 receptor tyrosine kinase 3; ERBB3; Erbb-3; Erbb3r; erbB3-S; glial growth factor receptor; HER3; human epidermal growth factor receptor 3; LCCS2; MDA BF 1; MDA-BF-1; MGC88033; nuc-ErbB3; p180 ErbB3; p180-ErbB3; p45 sErbB3; p45-sErbB3; p85 sErbB3; p85-sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; receptor tyrosine-protein kinase erbB-3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)