Ly-49E/F Monoclonal Antibody (CM4), PerCP-eFluor 710, eBioscience | Invitrogen 46-5848-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ly-49E/F Monoclonal Antibody (CM4), PerCP-eFluor 710, eBioscience

catalog :

46-5848-82

quantity :

100 ug

price :

US 437.00

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

CM4

reactivity :

mouse

application :

flow cytometry

citations: 3

Reference
Li Z, Morman R, Hegermiller E, Sun M, Bartom E, Maienschein Cline M, et al. The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. J Exp Med. 2021;218: pubmed publisher
Parikh B, Bern M, Piersma S, Yang L, Beckman D, Poursine Laurent J, et al. Control of Viral Infection by Natural Killer Cell Inhibitory Receptors. Cell Rep. 2020;32:107969 pubmed publisher
Gays F, Martin K, Kenefeck R, Aust J, Brooks C. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J Immunol. 2005;175:2938-47 pubmed

product information

Product Type :

Antibody

Product Name :

Ly-49E/F Monoclonal Antibody (CM4), PerCP-eFluor 710, eBioscience

Catalog # :

46-5848-82

Quantity :

100 ug

Price :

US 437.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

CM4

Isotype :

IgG2a

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The Ly49 family of receptors are clustered in the Natural Killer Cell complex on chromosome 6. Expression is confined to NK cell, lymphocytes that play a key role in protection from infection and malignant diseases as well as graft rejection and autoimmune diseases. Ly49E is unique from other family members in that it contains an ITIM (immunoreceptor tyrosine-based inhibitory motif) domain and is expressed on all mouse strains. Developmentally Ly49E is one of the first markers detected on NK cells but expression decreases after birth to about 1% of NK cells in the adult spleen. Upon stimulation, expression can again be induced on Ly49E negative cells. The CM4 antibody is a useful reagent for the characterization of Ly49E expression when used in combination with other Ly49 antibodies such as 14B11 (Ly49C/I/F/H), 3D10 (Ly49C), YLI-90 (Ly49I), and A1 (Ly49A).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

class I MHC receptor KLRA5; killer cell lectin-like receptor 5; Killer cell lectin-like receptor 6; killer cell lectin-like receptor, subfamily A, member 5; killer cell lectin-like receptor, subfamily A, member 6; Klra5; Klra6; Ly49e; Ly-49e; Ly49-e; Ly49E receptor; Ly49f; ly-49f; Ly49-f; Lymphocyte antigen 49e; lymphocyte antigen 49f; T-cell surface glycoprotein Ly-49E; T-cell surface glycoprotein Ly-49F