TCR V beta 8.1/8.2 Monoclonal Antibody (KJ16-133 (KJ-16, KJI6, KJ-I6)), PerCP-eFluor 710, eBioscience™ | Invitrogen 46-5813-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 8.1/8.2 Monoclonal Antibody (KJ16-133 (KJ-16, KJI6, KJ-I6)), PerCP-eFluor 710, eBioscience™

catalog :

46-5813-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

KJ16-133 (KJ-16, KJI6, KJ-I6)

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 2

Reference
Jimeno R, Lebrusant Fernandez M, Margreitter C, LUCAS B, Veerapen N, Kelly G, et al. Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells. elife. 2019;8: pubmed publisher
BRADLEY W, Holm K, Tanaka A. An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response. BMC Complement Altern Med. 2014;14:163 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TCR V beta 8.1/8.2 Monoclonal Antibody (KJ16-133 (KJ-16, KJI6, KJ-I6)), PerCP-eFluor 710, eBioscience™

Catalog # :

46-5813-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test

Species :

Mouse

Clone :

KJ16-133 (KJ-16, KJI6, KJ-I6)

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test

Aliases :

TCR V beta8.1; TCR V beta8.2; TCRV beta 8.1; TCRV beta8.1; Vb8.1; Vb8.2; Vbeta8.1; Vbeta8.2

more info or order :

Invitrogen product webpage