RELM alpha Monoclonal Antibody (DS8RELM), PerCP-eFluor 710, eBioscience | Invitrogen 46-5441-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RELM alpha Monoclonal Antibody (DS8RELM), PerCP-eFluor 710, eBioscience

catalog :

46-5441-82

quantity :

100 ug

price :

US 466.00

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

DS8RELM

reactivity :

mouse

application :

flow cytometry

citations: 2

Reference
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, et al. Mechanosensing regulates tissue repair program in macrophages. Sci Adv. 2024;10:eadk6906 pubmed publisher
Li J, Ruggiero Ruff R, He Y, Qiu X, Lainez N, Villa P, et al. Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils. elife. 2023;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

RELM alpha Monoclonal Antibody (DS8RELM), PerCP-eFluor 710, eBioscience

Catalog # :

46-5441-82

Quantity :

100 ug

Price :

US 466.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

DS8RELM

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages. Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages. It is strongly induced by IL-4 and IL-13. Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1. Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ. Elevated levels of RELM alpha may indicate parasitic infection. Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function. Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties. RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.

Immunogen :

Recombinant mouse RELM alpha protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2