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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), PerCP-eFluor™ 710, eBioscience
catalog :
46-2799-42
quantity :
100 Tests
price :
US 394
clonality :
monoclonal
host :
mouse
conjugate :
Percp/efluor 710
clone name :
eBioJ105 (J105)
reactivity :
African green monkey, human, rhesus macaque
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • flow cytometry; African green monkey; fig 1
Vargas Inchaustegui D, Demers A, Shaw J, Kang G, Ball D, Tuero I, et al. Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques. J Immunol. 2016;196:1700-10 pubmed publisher
Querfeld C, Leung S, Myskowski P, Curran S, Goldman D, Heller G, et al. Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Cancer Immunol Res. 2018;6:900-909 pubmed publisher
Zappasodi R, Budhu S, Hellmann M, Postow M, Senbabaoglu Y, Manne S, et al. Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer Cell. 2018;33:1017-1032.e7 pubmed publisher
Lee S, Adriani G, Ceccarello E, Pavesi A, Tan A, Bertoletti A, et al. Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model. Front Immunol. 2018;9:416 pubmed publisher
Vinton C, Ortiz A, Calantone N, Mudd J, Deléage C, Morcock D, et al. Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys. J Immunol. 2017;198:4403-4412 pubmed publisher
Jaworski J, Bryk P, Brower Z, Zheng B, Hessell A, Rosenberg A, et al. Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques. PLoS ONE. 2017;12:e0172524 pubmed publisher
Pen J, Keersmaecker B, Heirman C, Corthals J, Liechtenstein T, Escors D, et al. Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells. Gene Ther. 2014;21:262-71 pubmed publisher
Legat A, Speiser D, Pircher H, Zehn D, Fuertes Marraco S. Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8?T Cells. Front Immunol. 2013;4:455 pubmed publisher
Kim E, Kwun J, Gibby A, Hong J, Farris A, Iwakoshi N, et al. Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. Am J Transplant. 2014;14:59-69 pubmed publisher
Hood S, Mee E, Perkins H, Bowen O, Dale J, Almond N, et al. Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus). Virus Res. 2014;179:93-101 pubmed publisher
Kenway Lynch C, Das A, Pan D, Lackner A, Pahar B. Dynamics of cytokine/chemokine responses in intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection. J Virol. 2013;87:11916-23 pubmed publisher
Knol A, Nguyen J, Pandolfino M, Quereux G, Brocard A, Peuvrel L, et al. Tissue biomarkers in melanoma patients treated with TIL. PLoS ONE. 2012;7:e48729 pubmed publisher
Kataoka T, Fujimoto M, Moriyoshi K, Koyanagi I, Ueshima C, Kono F, et al. PD-1 regulates the growth of human mastocytosis cells. Allergol Int. 2013;62:99-104 pubmed publisher
Shaw J, Hunt P, Critchfield J, McConnell D, Garcia J, Pollard R, et al. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013;29:172-7 pubmed publisher
Brenchley J, Vinton C, Tabb B, Hao X, Connick E, Paiardini M, et al. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 2012;120:4172-81 pubmed publisher
Demberg T, Brocca Cofano E, Xiao P, Venzon D, Vargas Inchaustegui D, Lee E, et al. Dynamics of memory B-cell populations in blood, lymph nodes, and bone marrow during antiretroviral therapy and envelope boosting in simian immunodeficiency virus SIVmac251-infected rhesus macaques. J Virol. 2012;86:12591-604 pubmed publisher
Bandyopadhyay G, Bankey P, Miller Graziano C. Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis. Clin Immunol. 2012;145:44-54 pubmed publisher
Schunter M, Chu H, Hayes T, McConnell D, Crawford S, Luciw P, et al. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012;12:84 pubmed publisher
Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734-44 pubmed publisher
Jegaskanda S, Reece J, De Rose R, Stambas J, Sullivan L, Brooks A, et al. Comparison of influenza and SIV specific CD8 T cell responses in macaques. PLoS ONE. 2012;7:e32431 pubmed publisher
Klatt N, Vinton C, Lynch R, Canary L, Ho J, Darrah P, et al. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood. 2011;118:5803-12 pubmed publisher
Shaw J, Hunt P, Critchfield J, McConnell D, Garcia J, Pollard R, et al. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011;85:11422-34 pubmed publisher
Kim Y, Park S, Broxmeyer H. Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction. J Immunol. 2011;187:2291-301 pubmed publisher
Vagenas P, Aravantinou M, Williams V, Jasny E, Piatak M, Lifson J, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS ONE. 2010;5:e12891 pubmed publisher
Iwai Y, Okazaki T, Nishimura H, Kawasaki A, Yagita H, Honjo T. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 2002;83:215-20 pubmed
product information
Product Type :
Antibody
Product Name :
CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), PerCP-eFluor™ 710, eBioscience
Catalog # :
46-2799-42
Quantity :
100 Tests
Pricing :
US 394
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Rhesus Monkey
Applications :
Flow Cytometry: 5 µL (0.25 µg)/test
Species :
Human, Rhesus Monkey
Clone :
eBioJ105 (J105)
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.25 µg)/test
Aliases :
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA