CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), PerCP-eFluor 710, eBioscience | Invitrogen 46-2231-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), PerCP-eFluor 710, eBioscience

catalog :

46-2231-82

quantity :

100 ug

price :

US 329.00

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

eBioC9B7W (C9B7W)

reactivity :

mouse

application :

flow cytometry

citations: 27

Reference
Wu B, Qi L, Chiang H, Pan H, Zhang X, Greenbaum A, et al. BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity. J Immunother Cancer. 2023;11: pubmed publisher
Xie F, Zhou X, Su P, Li H, Tu Y, Du J, et al. Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nat Commun. 2022;13:4461 pubmed publisher
Burger M, Cruz A, Crossland G, Gaglia G, Ritch C, Blatt S, et al. Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors. Cell. 2021;184:4996-5014.e26 pubmed publisher
Sun Y, Lu D, Yin Y, Song J, Liu Y, Hao W, et al. PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. Nat Commun. 2021;12:5147 pubmed publisher
Wu C, Chen Z, Xiao S, Thalhamer T, Madi A, Han T, et al. SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. Cell Rep. 2018;22:653-665 pubmed publisher
Liu Z, Ravindranathan R, Kalinski P, Guo Z, Bartlett D. Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy. Nat Commun. 2017;8:14754 pubmed publisher
Di Marco Barros R, Roberts N, Dart R, Vantourout P, Jandke A, Nussbaumer O, et al. Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific Î³Î´ T Cell Compartments. Cell. 2016;167:203-218.e17 pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Goyvaerts C, Broos K, Escors D, Heirman C, Raes G, De Baetselier P, et al. The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome. Eur J Immunol. 2015;45:3351-61 pubmed publisher
Renkema K, Li G, Wu A, Smithey M, Nikolich Å½ugich J. Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J Immunol. 2014;192:151-9 pubmed publisher
Huang H, Dawicki W, Lu M, Nayyar A, Zhang X, Gordon J. Regulatory dendritic cell expression of MHCII and IL-10 are jointly requisite for induction of tolerance in a murine model of OVA-asthma. Allergy. 2013;68:1126-35 pubmed publisher
Huang H, Ma Y, Dawicki W, Zhang X, Gordon J. Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen. J Immunol. 2013;191:1136-43 pubmed publisher
Hu Z, Zhang W, Usherwood E. Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect. J Immunol. 2013;191:312-22 pubmed publisher
Cook K, Whitmire J. The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection. J Immunol. 2013;190:641-9 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
Brentville V, Metheringham R, Gunn B, Durrant L. High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment. PLoS ONE. 2012;7:e41112 pubmed publisher
Bak S, Barnkob M, Bai A, Higham E, Wittrup K, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16 pubmed publisher
Wilson J, Pack C, Lin E, Frost E, Albrecht J, Hadley A, et al. CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion. J Immunol. 2012;188:4340-8 pubmed publisher
Lee L, Baban D, Ronan E, Ragoussis J, Beverley P, Tchilian E. Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A. BMC Med Genomics. 2010;3:46 pubmed publisher
Van Deusen K, Rajapakse R, Bullock T. CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses. J Leukoc Biol. 2010;87:477-85 pubmed publisher
Lin Y, Chang L, Huang C, Peng H, Dutta A, Chen T, et al. Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity. J Immunol. 2009;182:6095-104 pubmed publisher
Deepe G, Gibbons R. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol. 2008;180:1088-97 pubmed
Pallandre J, Brillard E, Crehange G, Radlovic A, Remy Martin J, Saas P, et al. Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity. J Immunol. 2007;179:7593-604 pubmed
Workman C, Vignali D. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol. 2005;174:688-95 pubmed
Li N, Workman C, Martin S, Vignali D. Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). J Immunol. 2004;173:6806-12 pubmed
Huang C, Workman C, Flies D, Pan X, Marson A, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity. 2004;21:503-13 pubmed
Workman C, Rice D, Dugger K, Kurschner C, Vignali D. Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 2002;32:2255-63 pubmed

product information

Product Type :

Antibody

Product Name :

CD223 (LAG-3) Monoclonal Antibody (eBioC9B7W (C9B7W)), PerCP-eFluor 710, eBioscience

Catalog # :

46-2231-82

Quantity :

100 ug

Price :

US 329.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

eBioC9B7W (C9B7W)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3