CD194 (CCR4) Monoclonal Antibody (D8SEE), PerCP-eFluor 710, eBioscience | Invitrogen 46-1949-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD194 (CCR4) Monoclonal Antibody (D8SEE), PerCP-eFluor 710, eBioscience

catalog :

46-1949-42

quantity :

100 Tests

price :

US 475.00

clonality :

monoclonal

host :

mouse

conjugate :

Percp/efluor 710

clone name :

D8SEE

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Preglej T, Brinkmann M, Steiner G, Aletaha D, G xf6 schl L, Bonelli M. Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach. Front Immunol. 2023;14:1096096 pubmed publisher
Zou Y, Liang J, Li D, Fang J, Wang L, Wang J, et al. Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer. Oncol Lett. 2020;20:123-134 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD194 (CCR4) Monoclonal Antibody (D8SEE), PerCP-eFluor 710, eBioscience

Catalog # :

46-1949-42

Quantity :

100 Tests

Price :

US 475.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.125 ug)/test

Species :

Human

Clone :

D8SEE

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.125 ug)/test

Aliases :

C-C chemokine receptor 4; C-C chemokine receptor type 4; C-C CKR-4; C-C motif chemokine receptor 4; CC-CKR-4; Ccr4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; CHEMR1; ChemR13; CKR4; Cmkbr4; fusin; HGCN:14099; K5-5; LESTR; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293; Sdf1r