CD152 (CTLA-4) Monoclonal Antibody (14D3), PerCP-eFluor™ 710, eBioscience | Invitrogen 46-1529-41 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD152 (CTLA-4) Monoclonal Antibody (14D3), PerCP-eFluor™ 710, eBioscience

catalog :

46-1529-41

quantity :

25 Tests

price :

US 147

clonality :

monoclonal

host :

mouse

conjugate :

Percp/efluor 710

clone name :

14D3

reactivity :

human, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 27

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s3	Remmerswaal E, Hombrink P, Nota B, Pircher H, ten Berge I, van Lier R, et al. Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans. Eur J Immunol. 2019;49:694-708 pubmed publisher
flow cytometry; rhesus macaque; fig 2	Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
	Corgnac S, Damei I, Gros G, Caidi A, Terry S, Chouaib S, et al. Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model. J Immunother Cancer. 2022;10: pubmed publisher
	Cho J, Okuma A, Sofjan K, Lee S, Collins J, Wong W. Engineering advanced logic and distributed computing in human CAR immune cells. Nat Commun. 2021;12:792 pubmed publisher
	Todorova D, Zhang Y, Chen Q, Liu J, He J, Fu X, et al. hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts. EBioMedicine. 2020;62:103120 pubmed publisher
	Bai F, Zhang P, Fu Y, Chen H, Zhang M, Huang Q, et al. Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. J Immunother Cancer. 2020;8: pubmed publisher
	Wierzbinska J, Toth R, Ishaque N, Rippe K, Mallm J, Klett L, et al. Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL. Genome Med. 2020;12:29 pubmed publisher
	Savage T, Shonts B, Obradovic A, DeWolf S, Lau S, Zuber J, et al. Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight. 2018;3: pubmed publisher
	Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed publisher
	Syed Khaja A, Toor S, El Salhat H, Ali B, Elkord E. Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer. Front Immunol. 2017;8:619 pubmed publisher
	Syed Khaja A, Toor S, El Salhat H, Faour I, Ul Haq N, Ali B, et al. Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment. Oncotarget. 2017;8:33159-33171 pubmed publisher
	Ward F, Dahal L, Wijesekera S, Abdul Jawad S, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85 pubmed publisher
	Koristka S, Cartellieri M, Arndt C, Bippes C, Feldmann A, Michalk I, et al. Retargeting of regulatory T cells to surface-inducible autoantigen La/SS-B. J Autoimmun. 2013;42:105-16 pubmed publisher
	Olson B, Jankowska Gan E, Becker J, Vignali D, Burlingham W, McNeel D. Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. J Immunol. 2012;189:5590-601 pubmed publisher
	Presicce P, Moreno Fernandez M, Rusie L, Fichtenbaum C, Chougnet C. In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells. PLoS ONE. 2012;7:e42802 pubmed publisher
	Joffe M, Necula A, Chand R, McWhinney B, Krishnamurthy B, Loudovaris T, et al. Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors. Int Immunol. 2012;24:447-53 pubmed publisher
	Khalid M, Yu H, Sauter D, Usmani S, Schmökel J, Feldman J, et al. Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. J Virol. 2012;86:4906-20 pubmed publisher
	Skrindo I, Scheel C, Johansen F, Jahnsen F. Experimentally induced accumulation of Foxp3? T cells in upper airway allergy. Clin Exp Allergy. 2011;41:954-62 pubmed publisher
	Peggs K, Quezada S, Chambers C, Korman A, Allison J. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med. 2009;206:1717-25 pubmed publisher
	Horlock C, Stott B, Dyson P, Morishita M, Coombes R, Savage P, et al. The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer. Br J Cancer. 2009;100:1061-7 pubmed publisher
	Lages C, Suffia I, Velilla P, Huang B, Warshaw G, Hildeman D, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181:1835-48 pubmed
	Zhang Q, Qian F, Liu H, Zhou L, Huang M, Zhang X, et al. Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid. Chin Med J (Engl). 2008;121:205-12 pubmed
	Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud Gaubert M, Magnan A. CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients. Eur Respir J. 2008;31:1167-76 pubmed publisher
	Saverino D, Brizzolara R, Simone R, Chiappori A, Milintenda Floriani F, Pesce G, et al. Soluble CTLA-4 in autoimmune thyroid diseases: relationship with clinical status and possible role in the immune response dysregulation. Clin Immunol. 2007;123:190-8 pubmed
	Matsubar Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Delineation of immunoregulatory properties of adult T-cell leukemia cells. Int J Hematol. 2006;84:63-9 pubmed
	Leong P, Mohammad R, Ibrahim N, Ithnin H, Abdullah M, Davis W, et al. Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett. 2006;102:229-36 pubmed
	Bashuda H, Kimikawa M, Seino K, Kato Y, Ono F, Shimizu A, et al. Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest. 2005;115:1896-902 pubmed

product information

Product Type :

Antibody

Product Name :

CD152 (CTLA-4) Monoclonal Antibody (14D3), PerCP-eFluor™ 710, eBioscience

Catalog # :

46-1529-41

Quantity :

25 Tests

Pricing :

US 147

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Rhesus Monkey

Applications :

Flow Cytometry: 5 µL (0.03 µg)/test

Species :

Human, Rhesus Monkey

Clone :

14D3

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.03 µg)/test

Aliases :

ALPS5; CD; CD152; CD152 antigen; CD152 isoform; CD152 protein; CD152 protein precursor; celiac disease 3; CELIAC3; Ctla4; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; EGK_04712; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ly-56; sCTLA4; soluble form; transmembrane form

more info or order :

Invitrogen product webpage