CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), PerCP-eFluor™ 710, eBioscience | Invitrogen 46-1222-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), PerCP-eFluor™ 710, eBioscience

catalog :

46-1222-82

quantity :

100 µg

price :

US 357

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

TM-b1 (TM-beta1)

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s2c	Collins N, Han S, Enamorado M, Link V, Huang B, Moseman E, et al. The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. Cell. 2019;178:1088-1101.e15 pubmed publisher
flow cytometry; mouse; fig 1h	Linehan J, Harrison O, Han S, Byrd A, Vujkovic Cvijin I, Villarino A, et al. Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell. 2018;172:784-796.e18 pubmed publisher
	Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9:5340 pubmed publisher
	Ruscher R, Hogquist K. Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces. Bio Protoc. 2018;8: pubmed publisher
	Drennan M, Govindarajan S, Verheugen E, Coquet J, Staal J, McGuire C, et al. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20. J Exp Med. 2016;213:1973-81 pubmed publisher
	Liu R, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, et al. IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A. 2013;110:8158-63 pubmed publisher
	Hu S, Xiong N. Programmed downregulation of CCR6 is important for establishment of epidermal ??T cells by regulating their thymic egress and epidermal location. J Immunol. 2013;190:3267-75 pubmed publisher
	Sakuraba K, Shibata K, Iwamoto Y, Yoshikai Y, Yamada H. Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells. J Immunol. 2013;190:1560-6 pubmed publisher
	Kim J, Cha H, Kim E, Kweon M. Pathological effect of IL-17A-producing TCR??(+) T cells in mouse genital mucosa against HSV-2 infection. Immunol Lett. 2012;147:34-40 pubmed publisher
	Garidou L, Heydari S, Gossa S, McGavern D. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection. J Virol. 2012;86:7060-71 pubmed publisher
	Sun L, Hurez V, Thibodeaux S, Kious M, Liu A, Lin P, et al. Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. Aging Cell. 2012;11:509-19 pubmed publisher
	Yamashita J, Iwamura C, Mitsumori K, Hosokawa H, Sasaki T, Takahashi M, et al. Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leuk Lymphoma. 2012;53:479-86 pubmed publisher
	Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, et al. Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011;208:1749-56 pubmed publisher
	Castillo E, Acero L, Stonier S, Zhou D, Schluns K. Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood. 2010;116:2494-503 pubmed publisher
	Frasca L, Stonier S, Overwijk W, Schluns K. Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol. 2010;88:69-78 pubmed publisher
	Chappaz S, Finke D. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol. 2010;184:3562-9 pubmed publisher
	Croy B, Zhang J, Tayade C, Colucci F, Yadi H, Yamada A. Analysis of uterine natural killer cells in mice. Methods Mol Biol. 2010;612:465-503 pubmed publisher
	Sun Q, Jin H, Bond J. Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells. Exp Hematol. 2009;37:346-56 pubmed publisher
	Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, et al. Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model. Clin Cancer Res. 2008;14:7251-9 pubmed publisher
	Cush S, Anderson K, Ravneberg D, Weslow Schmidt J, Flano E. Memory generation and maintenance of CD8+ T cell function during viral persistence. J Immunol. 2007;179:141-53 pubmed
	Zheng S, Wang J, Wang P, Gray J, Horwitz D. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007;178:2018-27 pubmed
	Pelletier M, Girard D. Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells. J Immunol. 2006;177:100-8 pubmed
	So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006;103:3740-5 pubmed
	French J, Roark C, Born W, O Brien R. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005;102:14741-6 pubmed

product information

Product Type :

Antibody

Product Name :

CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), PerCP-eFluor™ 710, eBioscience

Catalog # :

46-1222-82

Quantity :

100 µg

Pricing :

US 357

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

TM-b1 (TM-beta1)

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

CD122; CD122 antigen; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL-15 receptor beta chain; IL15RB; IL15Rbeta; IL-15Rbeta; IL-2 receptor beta chain; IL-2 receptor subunit beta; IL-2/15 receptor-beta; Il-2/15Rbeta; IL-2R subunit beta; IL2RB; IL-2RB; IL2RBC; Il-2Rbeta; interleukin 15 receptor, beta; interleukin 2 receptor subunit beta; interleukin 2 receptor, beta; interleukin 2 receptor, beta chain; Interleukin-15 receptor subunit beta; Interleukin-2 receptor subunit beta; p70; p70-75; p75

more info or order :

Invitrogen product webpage