CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience | Invitrogen 46-1172-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience

catalog :

46-1172-80

quantity :

25 µg

price :

US 123

clonality :

monoclonal

host :

rat

conjugate :

Percp/efluor 710

clone name :

ACK2

reactivity :

mouse

application :

flow cytometry

citations: 12

Reference
Gentle I, Moelter I, Badr M, D xf6 hner K, L xfc bbert M, H xe4 cker G. The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression. Cell Death Dis. 2021;12:675 pubmed publisher
Naka K, Ochiai R, Matsubara E, Kondo C, Yang K, Hoshii T, et al. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2020;11:4681 pubmed publisher
Kwak M, Ninche N, Klein S, Saur D, Ghazizadeh S. c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells. Sci Rep. 2018;8:14193 pubmed publisher
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed publisher
Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed publisher
Astuti Y, Kramer A, Blake A, Blazar B, Tolar J, Taisto M, et al. A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing. Stem Cell Reports. 2017;8:177-190 pubmed publisher
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher
Puram R, Kowalczyk M, de Boer C, Schneider R, Miller P, McConkey M, et al. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell. 2016;165:303-16 pubmed publisher
Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed publisher
Schjerven H, McLaughlin J, Arenzana T, Frietze S, Cheng D, Wadsworth S, et al. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013;14:1073-83 pubmed publisher
Carmona R, Cano E, Mattiotti A, Gaztambide J, Muñoz Chápuli R. Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos. PLoS ONE. 2013;8:e55890 pubmed publisher
Czechowicz A, Kraft D, Weissman I, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 2007;318:1296-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD117 (c-Kit) Monoclonal Antibody (ACK2), PerCP-eFluor™ 710, eBioscience

Catalog # :

46-1172-80

Quantity :

25 µg

Price :

US 123

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

ACK2

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W