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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD73 Monoclonal Antibody (AD2), PerCP-eFluor™ 710, eBioscience
catalog :
46-0739-41
quantity :
25 Tests
price :
US 159
clonality :
monoclonal
host :
mouse
conjugate :
Percp/efluor 710
clone name :
AD2
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 39
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Vadasz S, JENSEN T, Moncada C, Girard E, Zhang F, Blanchette A, et al. Second and third trimester amniotic fluid mesenchymal stem cells can repopulate a de-cellularized lung scaffold and express lung markers. J Pediatr Surg. 2014;49:1554-63 pubmed publisher
Al Hosni R, Bozec L, Roberts S, Cheema U. Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension. iScience. 2022;25:104059 pubmed publisher
Turiello R, Capone M, Morretta E, Monti M, Madonna G, Azzaro R, et al. Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents. J Immunother Cancer. 2022;10: pubmed publisher
Park H, Choi J, Nam M, Seo Y. Induced Neurodifferentiation of hBM-MSCs through Activation of the ERK/CREB Pathway via Pulsed Electromagnetic Fields and Physical Stimulation Promotes Neurogenesis in Cerebral Ischemic Models. Int J Mol Sci. 2022;23: pubmed publisher
Jiang W, Zhang J, Zhang X, Fan C, Huang J. VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway. Bioengineered. 2021;12:10264-10284 pubmed publisher
Chen C, Huang X, Zhu W, Ding C, Huang P, Li R. TRPA1 triggers hyperalgesia and inflammation after tooth bleaching. Sci Rep. 2021;11:17418 pubmed publisher
Hou C, Wang X, Jiang W, Bian Z, Zhu L, Li M. Peptide 11R‑VIVIT promotes fracture healing in osteoporotic rats. Int J Mol Med. 2021;48: pubmed publisher
Li Y, Shi G, Han Y, Shang H, Li H, Liang W, et al. Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model. Stem Cell Res Ther. 2021;12:407 pubmed publisher
Xiao K, Yang L, Xie W, Gao X, Huang R, Xie M. Bcl-xL mutant promotes cartilage differentiation of BMSCs by upregulating TGF-β/BMP expression levels. Exp Ther Med. 2021;22:736 pubmed publisher
Babaei A, Bannazadeh Baghi H, Nezhadi A, Jamalpoor Z. In Vitro Anti-cancer Activity of Adipose-Derived Mesenchymal Stem Cells Increased after Infection with Oncolytic Reovirus. Adv Pharm Bull. 2021;11:361-370 pubmed publisher
García Alegría E, Potts B, Menegatti S, Kouskoff V. In vitro differentiation of human embryonic stem cells to hemogenic endothelium and blood progenitors via embryoid body formation. STAR Protoc. 2021;2:100367 pubmed publisher
Luzuriaga J, Irurzun J, Irastorza I, Unda F, Ibarretxe G, Pineda J. Vasculogenesis from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media. Biomedicines. 2020;8: pubmed publisher
Zhao A, Shah K, Freitag J, Cromer B, Sumer H. Differentiation Potential of Early- and Late-Passage Adipose-Derived Mesenchymal Stem Cells Cultured under Hypoxia and Normoxia. Stem Cells Int. 2020;2020:8898221 pubmed publisher
Schroeder J, Puntigam L, Hofmann L, Jeske S, Beccard I, Doescher J, et al. Circulating Exosomes Inhibit B Cell Proliferation and Activity. Cancers (Basel). 2020;12: pubmed publisher
Goloviznina N, Xie N, Dandapat A, Iaizzo P, Kyba M. Prospective isolation of human fibroadipogenic progenitors with CD73. Heliyon. 2020;6:e04503 pubmed publisher
Sun L, Zhu W, Zhao P, Zhang J, Lu Y, Zhu Y, et al. Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair. Front Cell Dev Biol. 2020;8:263 pubmed publisher
Deng Q, Huang S, Wen J, Jiao Y, Su X, Shi G, et al. PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice. Stem Cell Res Ther. 2020;11:143 pubmed publisher
Rim Y, Nam Y, Park N, Jung H, Lee K, Lee J, et al. Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors. Cells. 2020;9: pubmed publisher
Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, et al. Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro. Stem Cells Int. 2019;2019:8035076 pubmed publisher
Wang Y, Fu Y, Yan Z, Zhang X, Pei M. Impact of Fibronectin Knockout on Proliferation and Differentiation of Human Infrapatellar Fat Pad-Derived Stem Cells. Front Bioeng Biotechnol. 2019;7:321 pubmed publisher
Yan N, Xu J, Zhao C, Wu Y, Gao F, Li C, et al. Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice. Exp Ther Med. 2018;16:4445-4456 pubmed publisher
Wang D, Jiang X, Lu A, Tu M, Huang W, Huang P. BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cells in vitro. Exp Ther Med. 2018;16:1165-1174 pubmed publisher
Hajizadeh N, Madani Z, Zabihi E, Golpour M, Zahedpasha A, Mohammadnia M. Effect of MTA and CEM on Mineralization-Associated Gene Expression in Stem Cells Derived from Apical Papilla. Iran Endod J. 2018;13:94-101 pubmed publisher
Ziebart A, Huber U, Jeske S, Laban S, Doescher J, Hoffmann T, et al. The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma. Oncotarget. 2018;9:5834-5847 pubmed publisher
Gaskill C, Majka S. A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells. Pulm Circ. 2017;7:108-116 pubmed publisher
Li J, Mao Q, He J, She H, Zhang Z, Yin C. Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism. Stem Cell Res Ther. 2017;8:55 pubmed publisher
Webber B, Osborn M, McElroy A, Twaroski K, Lonetree C, Defeo A, et al. CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa. NPJ Regen Med. 2016;1: pubmed publisher
Camilleri E, Gustafson M, Dudakovic A, Riester S, Garces C, Paradise C, et al. Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Res Ther. 2016;7:107 pubmed publisher
Yao Y, Deng Q, Song W, Zhang H, Li Y, Yang Y, et al. MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia. Stem Cell Reports. 2016;7:249-62 pubmed publisher
Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
Umezaki Y, Hashimoto Y, Nishishita N, Kawamata S, Baba S. Human Gingival Integration-Free iPSCs; a Source for MSC-Like Cells. Int J Mol Sci. 2015;16:13633-48 pubmed publisher
Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, et al. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death Dis. 2014;5:e1567 pubmed publisher
Brandau S, Jakob M, Bruderek K, Bootz F, Giebel B, Radtke S, et al. Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes. PLoS ONE. 2014;9:e106903 pubmed publisher
Dudakovic A, Camilleri E, Riester S, Lewallen E, Kvasha S, Chen X, et al. High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells. J Cell Biochem. 2014;115:1816-28 pubmed publisher
Mendez J, Ghaedi M, Steinbacher D, Niklason L. Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds. Tissue Eng Part A. 2014;20:1735-46 pubmed publisher
Goudenege S, LeBel C, Huot N, Dufour C, Fujii I, Gekas J, et al. Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation. Mol Ther. 2012;20:2153-67 pubmed publisher
Deaglio S, Dwyer K, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-65 pubmed
Kobie J, Shah P, Yang L, Rebhahn J, Fowell D, Mosmann T. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol. 2006;177:6780-6 pubmed
Nakamura T, Kubagawa H, Ohno T, Cooper M. Characterization of an IgM Fc-binding receptor on human T cells. J Immunol. 1993;151:6933-41 pubmed
product information
Product Type :
Antibody
Product Name :
CD73 Monoclonal Antibody (AD2), PerCP-eFluor™ 710, eBioscience
Catalog # :
46-0739-41
Quantity :
25 Tests
Pricing :
US 159
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.06 µg)/test
Species :
Human
Clone :
AD2
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.06 µg)/test
Aliases :
2210401F01Rik; 5 nucleotidase, ecto; 5' nucleotidase, ecto; 5'-NT; 5'-nucleotidase; 5'-nucleotidase ecto; 5'-nucleotidase, ecto (CD73); AI447961; CALJA; CD73; E5NT; ecto-5'-nucleotidase; eN; eNT; NT; Nt5; Nt5e; NTE; Purine 5-Prime-Nucleotidase
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA