CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), PerCP-eFluor 710, eBioscience | Invitrogen 46-0626-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), PerCP-eFluor 710, eBioscience

catalog :

46-0626-80

quantity :

25 ug

price :

US 161.00

clonality :

monoclonal

host :

mouse

conjugate :

Percp/efluor 710

clone name :

Psel.KO2.3

reactivity :

human, mouse

application :

flow cytometry

citations: 13

Reference
Jeong S, Park J, Ryu Y, Kim W, Lee I, Kim J, et al. Myristica fragrans Extract Inhibits Platelet Desialylation and Activation to Ameliorate Sepsis-Associated Thrombocytopenia in a Murine CLP-Induced Sepsis Model. Int J Mol Sci. 2023;24: pubmed publisher
Van Bael J, Vandenbulcke A, Ahmed Belkacem A, Guichou J, Pawlotsky J, Samyn J, et al. Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity. Int J Mol Sci. 2023;24: pubmed publisher
Wang B, Xia M, Chen T, Li M, Shi D, Wang X, et al. Loss of Tet2 affects platelet function but not coagulation in mice. Blood Sci. 2020;2:129-136 pubmed publisher
Peng H, Wu H, Zhang G, Zhang W, Guo Y, Chang L, et al. Expression and Clinical Prognostic Value of Platelet NLRP3 in Acute Coronary Syndrome. Int J Gen Med. 2020;13:791-802 pubmed publisher
Rondina M, Voora D, Simon L, Schwertz H, Harper J, Lee O, et al. Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circ Res. 2020;126:501-516 pubmed publisher
Mendelson A, Strat A, Bao W, Rosston P, Fallon G, Ohrn S, et al. Mesenchymal stromal cells lower platelet activation and assist in platelet formation in vitro. JCI Insight. 2019;4: pubmed publisher
Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, et al. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. J Hematol Oncol. 2018;11:117 pubmed publisher
Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W, et al. Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Res. 2018;28:918-933 pubmed publisher
Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, et al. The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017;8:15426 pubmed publisher
Kraakman M, Lee M, Al Sharea A, Dragoljevic D, Barrett T, Montenont E, et al. Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J Clin Invest. 2017;127:2133-2147 pubmed publisher
Torres Filho I, Torres L, Valdez C, Salgado C, Cap A, Dubick M. Refrigerated platelets stored in whole blood up to 5 days adhere to thrombi formed during hemorrhagic hypotension in rats. J Thromb Haemost. 2017;15:163-175 pubmed publisher
Vogel S, Bodenstein R, Chen Q, Feil S, Feil R, Rheinlaender J, et al. Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest. 2015;125:4638-54 pubmed publisher
Faraday N, Schunke K, Saleem S, Fu J, Wang B, Zhang J, et al. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS ONE. 2013;8:e71447 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), PerCP-eFluor 710, eBioscience

Catalog # :

46-0626-80

Quantity :

25 ug

Price :

US 161.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 0.125 ug/test

Species :

Human, Mouse

Clone :

Psel.KO2.3

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test

Aliases :

CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp