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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD27 Monoclonal Antibody (O323), PerCP-eFluor 710, eBioscience™
catalog :
46-0279-42
quantity :
100 Tests
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
Percp/efluor 710
clone name :
O323
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 55
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 4d
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Cell Death Dis. 2020;11:973 pubmed publisher
Nguyen T, Sant S, Bird N, Grant E, Clemens E, Koutsakos M, et al. Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly. J Leukoc Biol. 2017;: pubmed publisher
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed publisher
Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, et al. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology. 2017;6:e1283460 pubmed publisher
Nguyen T, Bird N, Grant E, Miles J, Thomas P, Kotsimbos T, et al. Maintenance of the EBV-specific CD8+ TCR?? repertoire in immunosuppressed lung transplant recipients. Immunol Cell Biol. 2017;95:77-86 pubmed publisher
Thomas M, Demberg T, Vargas Inchaustegui D, Xiao P, Tuero I, Venzon D, et al. Rhesus macaque rectal and duodenal tissues exhibit B-cell sub-populations distinct from peripheral blood that continuously secrete antigen-specific IgA in short-term explant cultures. Vaccine. 2014;32:872-80 pubmed publisher
Baker J, Hullsiek K, Singh A, Wilson E, Henry K, Lichtenstein K, et al. Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort. AIDS. 2014;28:831-40 pubmed publisher
Lee D, Waschbisch A, Lämmer A, Doerfler A, Schwab S, Linker R. Immunological and clinical consequences of splenectomy in a multiple sclerosis patient treated with natalizumab. J Neuroinflammation. 2013;10:123 pubmed publisher
Ndungu F, Lundblom K, Rono J, Illingworth J, Eriksson S, Farnert A. Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers. Eur J Immunol. 2013;43:2919-29 pubmed publisher
Thedrez A, Lavoue V, Dessarthe B, Daniel P, Henno S, Jaffre I, et al. A quantitative deficiency in peripheral blood Vγ9Vδ2 cells is a negative prognostic biomarker in ovarian cancer patients. PLoS ONE. 2013;8:e63322 pubmed publisher
Feuth T, Arends J, Fransen J, Nanlohy N, van Erpecum K, Siersema P, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PLoS ONE. 2013;8:e59302 pubmed publisher
Labuda L, Ateba Ngoa U, Feugap E, Heeringa J, van der Vlugt L, Pires R, et al. Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Negl Trop Dis. 2013;7:e2094 pubmed publisher
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
Azevedo R, Soares M, Albuquerque A, Tendeiro R, Soares R, Martins M, et al. Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:703-12 pubmed publisher
Qiu Y, Huang Y, Chen J, Qiao D, Zeng G, Cai J. Depletion of IL-22 during culture enhanced antigen-driven IFN-? production by CD4(+)T cells from patients with active TB. Immunol Lett. 2013;150:48-53 pubmed publisher
Illingworth J, Butler N, Roetynck S, Mwacharo J, Pierce S, Bejon P, et al. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013;190:1038-47 pubmed publisher
Mock U, Thiele R, Uhde A, Fehse B, Horn S. Efficient lentiviral transduction and transgene expression in primary human B cells. Hum Gene Ther Methods. 2012;23:408-15 pubmed publisher
Cairo C, Sagnia B, Cappelli G, Colizzi V, Leke R, Leke R, et al. Human cord blood ?? T cells expressing public V?2 chains dominate the response to bisphosphonate plus interleukin-15. Immunology. 2013;138:346-60 pubmed publisher
Wege A, Florian C, Ernst W, Zimara N, Schleicher U, Hanses F, et al. Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response. PLoS Negl Trop Dis. 2012;6:e1741 pubmed publisher
Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed publisher
Portugal S, Doumtabe D, Traore B, Miller L, Troye Blomberg M, Doumbo O, et al. B cell analysis of ethnic groups in Mali with differential susceptibility to malaria. Malar J. 2012;11:162 pubmed publisher
Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa K, Murakami T, et al. Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient. J Clin Immunol. 2012;32:690-7 pubmed publisher
Boudová S, Li H, Sajadi M, Redfield R, Pauza C. Impact of persistent HIV replication on CD4 negative V?2V?2 T cells. J Infect Dis. 2012;205:1448-55 pubmed publisher
So N, Ostrowski M, Gray Owen S. Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J Immunol. 2012;188:4008-22 pubmed publisher
van der Vlugt L, Labuda L, Ozir Fazalalikhan A, Lievers E, Gloudemans A, Liu K, et al. Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS ONE. 2012;7:e30883 pubmed publisher
Paíno T, Ocio E, Paiva B, San Segundo L, Garayoa M, Gutierrez N, et al. CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype. Haematologica. 2012;97:1110-4 pubmed publisher
Biswas S, Chang H, Sarkis P, Fikrig E, Zhu Q, Marasco W. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011;134:419-33 pubmed publisher
Duchez S, Rodrigues M, Bertrand F, Valitutti S. Reciprocal polarization of T and B cells at the immunological synapse. J Immunol. 2011;187:4571-80 pubmed publisher
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Plet A, et al. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice. Eur J Immunol. 2011;41:2883-93 pubmed publisher
Haufe S, Haug M, Schepp C, Kuemmerle Deschner J, Hansmann S, Rieber N, et al. Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells. Arthritis Rheum. 2011;63:3153-62 pubmed publisher
Wege A, Ernst W, Eckl J, Frankenberger B, Vollmann Zwerenz A, Männel D, et al. Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer. 2011;129:2194-206 pubmed publisher
Monteiro P, Gosselin A, Wacleche V, El Far M, Said E, Kared H, et al. Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin ?7. J Immunol. 2011;186:4618-30 pubmed publisher
Brocca Cofano E, McKinnon K, Demberg T, Venzon D, Hidajat R, Xiao P, et al. Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia. Vaccine. 2011;29:3310-9 pubmed publisher
Carotenuto P, Artsen A, Osterhaus A, Pontesilli O. Reciprocal changes of naïve and effector/memory CD8+ T lymphocytes in chronic hepatitis B virus infection. Viral Immunol. 2011;24:27-33 pubmed publisher
Kuzin I, Sun H, Moshkani S, Feng C, Mantalaris A, Wu J, et al. Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor. Biotechnol Bioeng. 2011;108:1430-40 pubmed publisher
Libri V, Azevedo R, Jackson S, Di Mitri D, Lachmann R, Fuhrmann S, et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology. 2011;132:326-39 pubmed publisher
Zhao L, Li Y, Smith M, Wang J, Zhang W, Tang F, et al. Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients. Lupus. 2010;19:1534-49 pubmed publisher
Burt T, Seu L, Mold J, Kappas A, McCune J. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol. 2010;185:5279-88 pubmed publisher
Cairo C, Armstrong C, Cummings J, Deetz C, Tan M, Lu C, et al. Impact of age, gender, and race on circulating ?? T cells. Hum Immunol. 2010;71:968-75 pubmed publisher
Zuo J, Church J, Belzer M, Kitchen C, Ank B, Schmid I, et al. Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy. AIDS Res Hum Retroviruses. 2010;26:681-4 pubmed publisher
Ness Schwickerath K, Jin C, Morita C. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol. 2010;184:7268-80 pubmed publisher
Freeman C, Han M, Martinez F, Murray S, Liu L, Chensue S, et al. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol. 2010;184:6504-13 pubmed publisher
Moura R, Weinmann P, Pereira P, Caetano Lopes J, Canhao H, Sousa E, et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford). 2010;49:1082-92 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed publisher
Han S, Huang Y, Liang Y, Ho Y, Wang Y, Chang L. Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications. J Hematol Oncol. 2009;2:34 pubmed publisher
Riedel D, Sajadi M, Armstrong C, Cummings J, Cairo C, Redfield R, et al. Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells. AIDS. 2009;23:1955-64 pubmed publisher
Agopian J, Navarro J, Gac A, Lecluse Y, Briand M, Grenot P, et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med. 2009;206:1473-83 pubmed publisher
Lages C, Suffia I, Velilla P, Huang B, Warshaw G, Hildeman D, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181:1835-48 pubmed
Cognasse F, Hamzeh Cognasse H, Lafarge S, Chavarin P, Pozzetto B, Richard Y, et al. Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Immunology. 2008;125:430-7 pubmed publisher
Ali Z, Shao L, Halliday L, Reichenberg A, Hintz M, Jomaa H, et al. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques. J Immunol. 2007;179:8287-96 pubmed
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Wei C, Anolik J, Cappione A, Zheng B, Pugh Bernard A, Brooks J, et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol. 2007;178:6624-33 pubmed
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
Infantino S, Moepps B, Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol. 2006;176:2197-207 pubmed
product information
Product Type :
Antibody
Product Name :
CD27 Monoclonal Antibody (O323), PerCP-eFluor 710, eBioscience™
Catalog # :
46-0279-42
Quantity :
100 Tests
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.06 µg)/test
Species :
Human
Clone :
O323
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.06 µg)/test
Aliases :
CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA