product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MTCO1 Monoclonal Antibody (1D6E1A8)
catalog :
459600
quantity :
100 µg
price :
US 454
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1D6E1A8
reactivity :
guinea pig, domestic goat, African green monkey, human, mouse, rat, bovine, zebrafish , roundworm
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 108
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig s2l
Basse A, Agerholm M, Farup J, Dalbram E, Nielsen J, Ørtenblad N, et al. Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity. Mol Metab. 2021;53:101271 pubmed publisher
  • western blot; human; 1:1000; fig s5d
Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, et al. Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep. 2021;35:109024 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5d-5f
Affortit C, Casas F, Ladrech S, Ceccato J, Bourien J, Coyat C, et al. Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor. BMC Biol. 2021;19:18 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4c
Yang F, Yang L, Wataya Kaneda M, Teng L, Katayama I. Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model. PLoS ONE. 2020;15:e0228204 pubmed publisher
  • western blot; mouse; loading ...; fig s3d
Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, et al. Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse. Sci Adv. 2019;5:eaav9824 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T, et al. Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death. J Biol Chem. 2017;292:4727-4742 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 2a
Hammerling B, Najor R, Cortez M, Shires S, Leon L, Gonzalez E, et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017;8:14050 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2
Cabre R, Naudi A, Dominguez Gonzalez M, Ayala V, Jove M, Mota Martorell N, et al. Sixty years old is the breakpoint of human frontal cortex aging. Free Radic Biol Med. 2017;103:14-22 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 6a
Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, et al. The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying. PLoS Genet. 2016;12:e1006463 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
Ivarsson N, Schiffer T, Hernandez A, Lanner J, Weitzberg E, Lundberg J, et al. Dietary nitrate markedly improves voluntary running in mice. Physiol Behav. 2017;168:55-61 pubmed publisher
  • western blot; mouse; fig 6
Inoue T, Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S, et al. Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. Am J Physiol Heart Circ Physiol. 2016;311:H509-19 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 7
Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, et al. MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem. 2016;291:16448-61 pubmed publisher
  • western blot; mouse; fig S2
Megyesi J, Tarcsafalvi A, Seng N, Hodeify R, Price P. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discov. 2016;2: pubmed
  • western blot; mouse; 1:1000; fig 3
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016;17:953-64 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 4
Winter L, Türk M, Harter P, Mittelbronn M, Kornblum C, Norwood F, et al. Downstream effects of plectin mutations in epidermolysis bullosa simplex with muscular dystrophy. Acta Neuropathol Commun. 2016;4:44 pubmed publisher
  • western blot; human; loading ...; fig 3d
Swiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, et al. Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 2016;7:28821-35 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 2
Weiher H, Pircher H, Jansen Dürr P, Hegenbarth S, Knolle P, Grunau S, et al. A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells. BMC Res Notes. 2016;9:128 pubmed publisher
  • western blot; mouse; fig s3a
Wai T, García Prieto J, Baker M, Merkwirth C, Benit P, Rustin P, et al. Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science. 2015;350:aad0116 pubmed publisher
  • western blot; mouse; fig 5
Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:50; fig 3
Strauss J, Shaw C, Bradley H, Wilson O, Dorval T, Pilling J, et al. Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria. Physiol Rep. 2016;4: pubmed publisher
  • western blot; mouse
Fentz J, Kjøbsted R, Kristensen C, Hingst J, Birk J, Gudiksen A, et al. AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2015;309:E900-14 pubmed publisher
  • western blot; human
Gineste C, Hernandez A, Ivarsson N, Cheng A, Naess K, Wibom R, et al. Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy. Hum Mol Genet. 2015;24:6580-7 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 8
Yoshida S, Yamamoto H, Tetsui T, Kobayakawa Y, Hatano R, Mukaisho K, et al. Effects of ezrin knockdown on the structure of gastric glandular epithelia. J Physiol Sci. 2016;66:53-65 pubmed publisher
  • immunocytochemistry; mouse; fig s4
Alam S, Hennigar S, Gallagher C, Soybel D, Kelleher S. Exome Sequencing of SLC30A2 Identifies Novel Loss- and Gain-of-Function Variants Associated with Breast Cell Dysfunction. J Mammary Gland Biol Neoplasia. 2015;20:159-72 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Sasaki M, Hsu M, Yeh M, Nakanuma Y. In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins. Virchows Arch. 2015;467:417-25 pubmed publisher
  • immunocytochemistry; mouse; 1:1000
  • western blot; mouse; 1:1000
Kubli D, Cortez M, Moyzis A, Najor R, Lee Y, Gustafsson Ã. PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLoS ONE. 2015;10:e0130707 pubmed publisher
  • western blot; mouse; fig 2
Winter L, Kuznetsov A, Grimm M, Zeöld A, Fischer I, Wiche G. Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle. Hum Mol Genet. 2015;24:4530-44 pubmed publisher
  • western blot; human; 1:2000; fig 6
Monaghan R, Barnes R, Fisher K, Andreou T, Rooney N, Poulin G, et al. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Nat Cell Biol. 2015;17:782-92 pubmed publisher
  • western blot; mouse; fig 1, 6
Mauro Lizcano M, Esteban Martínez L, Seco E, Serrano Puebla A, García Ledo L, Figueiredo Pereira C, et al. New method to assess mitophagy flux by flow cytometry. Autophagy. 2015;11:833-43 pubmed publisher
  • western blot; mouse
Brandauer J, Andersen M, Kellezi H, Risis S, Frøsig C, Vienberg S, et al. AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD. Front Physiol. 2015;6:85 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Macé V, Ahluwalia A, Coron E, Le Rhun M, Boureille A, Bossard C, et al. Confocal laser endomicroscopy: a new gold standard for the assessment of mucosal healing in ulcerative colitis. J Gastroenterol Hepatol. 2015;30 Suppl 1:85-92 pubmed publisher
  • western blot; mouse
Ikeda M, Ide T, Fujino T, Arai S, Saku K, Kakino T, et al. Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress. PLoS ONE. 2015;10:e0119687 pubmed publisher
  • western blot; human
Martínez Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher
  • western blot; human; 1:1000
Emperador S, Pacheu Grau D, Bayona Bafaluy M, Garrido Pérez N, Martín Navarro A, López Pérez M, et al. An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations. Front Genet. 2014;5:469 pubmed publisher
  • western blot; rat; 1:1000
Quan X, Nguyen T, Choi S, Xu S, Das R, Cha S, et al. Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. J Biol Chem. 2015;290:4086-96 pubmed publisher
  • western blot; mouse; 1 ug/ml; fig s1
Robertson A, Robertson J, Fusser M, Klungland A. Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Res. 2014;42:13280-93 pubmed publisher
  • immunocytochemistry; human; fig s1
Lucken Ardjomande Häsler S, Vallis Y, Jolin H, McKenzie A, McMahon H. GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions. J Cell Sci. 2014;127:4602-19 pubmed publisher
  • western blot; rat; 1:1000
Kobayashi M, Hoshinaga Y, Miura N, Tokuda Y, Shigeoka S, Murai A, et al. Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats. Biosci Biotechnol Biochem. 2014;78:1060-6 pubmed publisher
  • immunocytochemistry; mouse; fig s12b
Chen M, Hong M, Sun H, Wang L, Shi X, Gilbert B, et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. Nat Med. 2014;20:503-10 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Pezeshki A, Chelikani P. Effects of Roux-en-Y gastric bypass and ileal transposition surgeries on glucose and lipid metabolism in skeletal muscle and liver. Surg Obes Relat Dis. 2014;10:217-28 pubmed publisher
  • western blot; human
Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592:1873-86 pubmed publisher
  • western blot; rat; 1:500; fig 3
Sanchez Roman I, Gomez A, Naudi A, Jove M, Gomez J, Lopez Torres M, et al. Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress. J Bioenerg Biomembr. 2014;46:159-72 pubmed publisher
  • immunocytochemistry; mouse; 5 ug/ml; fig 3
Das R, Xu S, Quan X, Nguyen T, Kong I, Chung C, et al. Upregulation of mitochondrial Nox4 mediates TGF-?-induced apoptosis in cultured mouse podocytes. Am J Physiol Renal Physiol. 2014;306:F155-67 pubmed publisher
  • western blot; rat; fig 9
Dun Y, Vargas J, Brot N, Finnemann S. Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells. Free Radic Biol Med. 2013;65:1340-1351 pubmed publisher
  • western blot; mouse; fig 2
Rivera Torres J, Acin Perez R, Cabezas Sánchez P, Osorio F, Gonzalez Gomez C, Megias D, et al. Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture. J Proteomics. 2013;91:466-77 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3
Shadrach K, Rayborn M, Hollyfield J, Bonilha V. DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE). PLoS ONE. 2013;8:e67983 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 3
Yamaguchi T, Omori M, Tanaka N, Fukui N. Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts. Am J Physiol Cell Physiol. 2013;305:C323-33 pubmed publisher
  • western blot; human; fig 3
Jourdain A, Koppen M, Wydro M, Rodley C, Lightowlers R, Chrzanowska Lightowlers Z, et al. GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab. 2013;17:399-410 pubmed publisher
  • western blot; mouse
Kristensen J, Larsen S, Helge J, Dela F, Wojtaszewski J. Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS ONE. 2013;8:e53533 pubmed publisher
  • immunohistochemistry - frozen section; human
Shepherd S, Cocks M, Tipton K, Ranasinghe A, Barker T, Burniston J, et al. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. J Physiol. 2013;591:657-75 pubmed publisher
  • western blot; guinea pig; 1:1000
Gonon A, Jung C, Katz A, Westerblad H, Shemyakin A, Sjöquist P, et al. Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production. PLoS ONE. 2012;7:e42038 pubmed publisher
  • western blot; human; fig 2
Jensen T, Leutert R, Rasmussen S, Mouatt J, Christiansen M, Jensen B, et al. EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle. PLoS ONE. 2012;7:e31054 pubmed publisher
  • western blot; human; fig 2
Tucker E, Hershman S, Köhrer C, Belcher Timme C, Patel J, Goldberger O, et al. Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell Metab. 2011;14:428-34 pubmed publisher
  • western blot; mouse; fig s1
Dun M, Smith N, Baker M, Lin M, Aitken R, Nixon B. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. J Biol Chem. 2011;286:36875-87 pubmed publisher
  • immunocytochemistry; human; fig 8
Pircher H, Straganz G, Ehehalt D, Morrow G, Tanguay R, Jansen Durr P. Identification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvase. J Biol Chem. 2011;286:36500-8 pubmed publisher
  • western blot; mouse
Haase T, Ringholm S, Leick L, Biensø R, Kiilerich K, Johansen S, et al. Role of PGC-1? in exercise and fasting-induced adaptations in mouse liver. Am J Physiol Regul Integr Comp Physiol. 2011;301:R1501-9 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 1
Lauritzen K, Cheng C, Wiksen H, Bergersen L, Klungland A. Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair (Amst). 2011;10:639-53 pubmed publisher
  • western blot; human; fig 6
Glatz C, D Aco K, Smith S, Sondheimer N. Mutation in the mitochondrial tRNA(Val) causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes. Mitochondrion. 2011;11:615-9 pubmed publisher
  • western blot; human; 1:400; fig 1
Brosel S, Yang H, Tanji K, Bonilla E, Schon E. Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease. Am J Pathol. 2010;177:2541-8 pubmed publisher
  • western blot; mouse; 1:5000; fig 2
Aguirre E, Cadenas S. GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart. Biochim Biophys Acta. 2010;1797:1716-26 pubmed publisher
  • western blot; human; 1:1000; fig 7
Li M, Zhong Z, Zhu J, Xiang D, Dai N, Cao X, et al. Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1. J Biol Chem. 2010;285:14871-81 pubmed publisher
  • western blot; human; fig 6
López Royuela N, Balsas P, Galán Malo P, Anel A, Marzo I, Naval J. Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. Biochim Biophys Acta. 2010;1803:311-22 pubmed publisher
  • immunocytochemistry; human
  • immunocytochemistry; African green monkey; tbl 1
Berryman M, Goldenring J. CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil Cytoskeleton. 2003;56:159-72 pubmed
  • western blot; bovine
  • western blot; human
Capaldi R, Marusich M, Taanman J. Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol. 1995;260:117-32 pubmed
Borna N, Kishita Y, Sakai N, Hamada Y, Kamagata K, Kohda M, et al. Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL. Genes (Basel). 2020;11: pubmed publisher
Elouej S, Harhouri K, Le Mao M, Baujat G, Nampoothiri S, Kayserili H, et al. Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology. Nat Commun. 2020;11:4589 pubmed publisher
Kishita Y, Shimura M, Kohda M, Akita M, Imai Okazaki A, Yatsuka Y, et al. A novel homozygous variant in MICOS13/QIL1 causes hepato-encephalopathy with mitochondrial DNA depletion syndrome. Mol Genet Genomic Med. 2020;8:e1427 pubmed publisher
Garcia Poyatos C, Cogliati S, Calvo E, Hernansanz Agustín P, Lagarrigue S, Magni R, et al. Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish. EMBO Rep. 2020;21:e50287 pubmed publisher
Formosa L, Muellner Wong L, Reljic B, Sharpe A, Jackson T, Beilharz T, et al. Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I. Cell Rep. 2020;31:107541 pubmed publisher
Kim B, Jeong Y, Wong M, Martin L. DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations. Acta Neuropathol Commun. 2020;8:7 pubmed publisher
Whytock K, Parry S, Turner M, Woods R, James L, Ferguson R, et al. A 7-day high-fat, high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle. J Physiol. 2020;598:1151-1167 pubmed publisher
Kasahara T, Kubota Sakashita M, Nagatsuka Y, Hirabayashi Y, Hanasaka T, Tohyama K, et al. Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. FASEB J. 2020;34:1465-1480 pubmed publisher
Hara T, Shibata Y, Amagai R, Okado Matsumoto A. Use of in-gel peroxidase assay for cytochrome c to visualize mitochondrial complexes III and IV. Biol Open. 2020;9: pubmed publisher
Dollerup O, Chubanava S, Agerholm M, Søndergård S, Altıntaş A, Møller A, et al. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men. J Physiol. 2020;598:731-754 pubmed publisher
Choi S, Pfleger J, Jeon Y, Yang Z, He M, Shin H, et al. Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications. Biochim Biophys Acta Gene Regul Mech. 2019;1862:194436 pubmed publisher
Son S, Chau G, Kim S, Um S. Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling. Cells. 2019;8: pubmed publisher
Onder Y, Laothamatas I, Berto S, Sewart K, Kilaru G, Bordieanu B, et al. The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue. iScience. 2019;19:83-92 pubmed publisher
Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, et al. SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Mol Metab. 2019;: pubmed publisher
Klacanova K, Kovalská M, Chomova M, Pilchova I, Tatarkova Z, Kaplan P, et al. Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus. Int J Mol Med. 2019;43:2420-2428 pubmed publisher
Woodall B, Orogo A, Najor R, Cortez M, Moreno E, Wang H, et al. Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice. JCI Insight. 2019;5: pubmed publisher
Polyzos A, Lee D, Datta R, Hauser M, Budworth H, Holt A, et al. Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice. Cell Metab. 2019;29:1258-1273.e11 pubmed publisher
Sotirchos V, Fujisawa S, Vakiani E, Solomon S, Manova Todorova K, Sofocleous C. Fluorescent Tissue Assessment of Colorectal Cancer Liver Metastases Ablation Zone: A Potential Real-Time Biomarker of Complete Tumor Ablation. Ann Surg Oncol. 2019;26:1833-1840 pubmed publisher
De Luise M, Guarnieri V, Ceccarelli C, D Agruma L, Porcelli A, Gasparre G. A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma. Oxid Med Cell Longev. 2019;2019:8069583 pubmed publisher
Ivarsson N, Mattsson C, Cheng A, Bruton J, Ekblom B, Lanner J, et al. SR Ca2+ leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance. J Gen Physiol. 2019;151:567-577 pubmed publisher
Ghanem L, Mansour I, Abulata N, Akl M, Demerdash Z, El Baz H, et al. Liver Macrophage Depletion Ameliorates The Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver. Sci Rep. 2019;9:35 pubmed publisher
Haberman Y, Karns R, Dexheimer P, Schirmer M, Somekh J, Jurickova I, et al. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun. 2019;10:38 pubmed publisher
Nadeau L, Patten D, Caron A, Garneau L, Pinault Masson E, Foretz M, et al. IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation. Biochim Biophys Acta Gen Subj. 2019;1863:395-407 pubmed publisher
Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, et al. Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019;11: pubmed publisher
Kory N, Wyant G, Prakash G, Uit de Bos J, Bottanelli F, Pacold M, et al. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science. 2018;362: pubmed publisher
Palomo G, Granatiero V, Kawamata H, Konràd C, Kim M, Arreguin A, et al. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS. EMBO Mol Med. 2018;10: pubmed publisher
Torralba D, Baixauli F, Villarroya Beltri C, Fernandez Delgado I, Latorre Pellicer A, Acin Perez R, et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018;9:2658 pubmed publisher
Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid C, et al. CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep. 2018;19: pubmed publisher
El Merhie N, Baumgart Vogt E, Pilatz A, Pfreimer S, Pfeiffer B, Pak O, et al. Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung. Oxid Med Cell Longev. 2017;2017:9169146 pubmed publisher
Boutoual R, Meseguer S, Villarroya M, Martin Hernandez E, Errami M, Martin M, et al. Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep. 2018;8:1163 pubmed publisher
Saita S, Tatsuta T, Lampe P, König T, Ohba Y, Langer T. PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. EMBO J. 2018;37: pubmed publisher
Milosevic T, Payen V, Sonveaux P, Muccioli G, Tulkens P, Van Bambeke F. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Gomez Velazquez M, Badia Careaga C, Lechuga Vieco A, Nieto Arellano R, Tena J, Rollán I, et al. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart. PLoS Genet. 2017;13:e1006985 pubmed publisher
Hammerling B, Shires S, Leon L, Cortez M, Gustafsson A. Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin. Small Gtpases. 2017;:1-8 pubmed publisher
Yi C, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, et al. TNFα drives mitochondrial stress in POMC neurons in obesity. Nat Commun. 2017;8:15143 pubmed publisher
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
Esteban Martínez L, Sierra Filardi E, McGreal R, Salazar Roa M, Mariño G, Seco E, et al. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 2017;36:1688-1706 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
MTCO1 Monoclonal Antibody (1D6E1A8)
Catalog # :
459600
Quantity :
100 µg
Price :
US 454
Clonality :
Monoclonal
Purity :
Ammonium sulfate precipitation
Host :
Mouse
Reactivity :
Avian, Bovine, C. elegans, Goat, Hamster, Human, Mouse, Porcine, Rat, Rhesus Monkey, Zebrafish
Applications :
Flow Cytometry: 1 µg/1x10^6 cells, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 0.5-1 µg/mL
Species :
Avian, Bovine, C. elegans, Goat, Hamster, Human, Mouse, Porcine, Rat, Rhesus Monkey, Zebrafish
Clone :
1D6E1A8
Isotype :
IgG2a, kappa
Storage :
4° C, do not freeze
Description :
Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. It is composed of 13 polypeptides. Subunits I, II, and III (MTCO1, MTCO2, MTCO3) are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, and VIII are nuclear encoded. The cytochrome c oxidase family of enzymes have 4 redox centers, 2 hemes and 2 copper centers. In mitochondrial Complex IV, the 2 hemes are a and a3 and the 2 coppers are CuA and CuB. The 2 hemes and CuB are bound to subunit I. Acin-Perez et al. (2003) identified a cell line containing single and double missense mutations in the cytochrome c oxidase (COX) subunit I gene of mouse mitochondrial DNA. And they hypothesized that deleterious mutations can arise and become predominant; cultured cells can maintain several mtDNA haplotypes at stable frequencies; the respiratory chain has little spare COX capacity; and that the size of a cavity in the vicinity of val421 in MTCO1I of animal COX may affect the function of the enzyme.
Immunogen :
Human Mitochondrial Complex IV subunit I
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/1x10^6 cells, Immunocytochemistry: 5 µg/ml, Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 0.5-1 µg/mL
Aliases :
Co1; coi; cox1; coxi; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; mtco1; mt-co1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA