product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
ATP5A1 Monoclonal Antibody (7H10BD4F9)
catalog :
459240
quantity :
100 µg
price :
US 455
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7H10BD4F9
reactivity :
human, mouse, rat, bovine
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 32
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 3a, 3b
Bosch M, Sánchez Alvarez M, Fajardo A, Kapetanovic R, Steiner B, Dutra F, et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science. 2020;370: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 6b
Srikuea R, Hirunsai M, Charoenphandhu N. Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing. Sci Rep. 2020;10:8239 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig e4a
Hoshino A, Wang W, Wada S, McDermott Roe C, Evans C, Gosis B, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575:375-379 pubmed publisher
  • western blot; mouse; loading ...; fig s2e
Hammerschmidt P, Ostkotte D, Nolte H, Gerl M, Jais A, Brunner H, et al. CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019;177:1536-1552.e23 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
  • western blot; rat; 1:500; loading ...
Merdzo I, Rutkai I, Sure V, McNulty C, Katakam P, Busija D. Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes. J Vasc Res. 2017;54:1-12 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig s6c
  • western blot; mouse; 1:1000; loading ...; fig s6c
Cao L, Riascos Bernal D, Chinnasamy P, Dunaway C, Hou R, Pujato M, et al. Control of mitochondrial function and cell growth by the atypical cadherin Fat1. Nature. 2016;539:575-578 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Winter L, Wittig I, Peeva V, Eggers B, Heidler J, Chevessier F, et al. Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue. Acta Neuropathol. 2016;132:453-73 pubmed publisher
  • western blot; human; fig 3
Patra M, Mahata S, Padhan D, Sen M. CCN6 regulates mitochondrial function. J Cell Sci. 2016;129:2841-51 pubmed publisher
  • western blot; mouse; fig 2
Molla B, Riveiro F, Bolinches Amorós A, Muñoz Lasso D, Palau F, Gonzalez Cabo P. Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia. Dis Model Mech. 2016;9:647-57 pubmed publisher
  • western blot; rat; 1:500; fig 6
Merdzo I, Rutkai I, Tokés T, Sure V, Katakam P, Busija D. The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats. Am J Physiol Heart Circ Physiol. 2016;310:H830-8 pubmed publisher
  • western blot; mouse; fig 5
Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
  • western blot; rat; 1:500
Rutkai I, Dutta S, Katakam P, Busija D. Dynamics of enhanced mitochondrial respiration in female compared with male rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2015;309:H1490-500 pubmed publisher
  • western blot; mouse; 1:1000
Oláh G, Szczesny B, Brunyánszki A, López García I, Gerö D, Radák Z, et al. Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. PLoS ONE. 2015;10:e0134227 pubmed publisher
  • western blot; rat; 1:500
Rutkai I, Katakam P, Dutta S, Busija D. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies. Am J Physiol Heart Circ Physiol. 2014;307:H958-66 pubmed publisher
  • western blot; human; fig 11
Guardia Laguarta C, Area Gomez E, Rüb C, Liu Y, Magrane J, Becker D, et al. ?-Synuclein is localized to mitochondria-associated ER membranes. J Neurosci. 2014;34:249-59 pubmed publisher
  • western blot; bovine; fig 1
Wood K, Awda B, Fitzsimmons C, Miller S, McBride B, Swanson K. Influence of pregnancy in mid-to-late gestation on circulating metabolites, visceral organ mass, and abundance of proteins relating to energy metabolism in mature beef cows. J Anim Sci. 2013;91:5775-84 pubmed publisher
  • western blot; bovine; fig 1
Geletu M, Guy S, Raptis L. Effects of SRC and STAT3 upon gap junctional, intercellular communication in lung cancer lines. Anticancer Res. 2013;33:4401-10 pubmed
  • western blot; mouse; 1:2000; fig s15
Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai Kanai E, Ueyama T, et al. Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun. 2013;4:2308 pubmed publisher
  • western blot; bovine; 1:5000; fig 2
Wood K, Awda B, Fitzsimmons C, Miller S, McBride B, Swanson K. Effect of moderate dietary restriction on visceral organ weight, hepatic oxygen consumption, and metabolic proteins associated with energy balance in mature pregnant beef cows. J Anim Sci. 2013;91:4245-55 pubmed publisher
  • western blot; rat; 1:2000; fig 5
Wappler E, Institoris A, Dutta S, Katakam P, Busija D. Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. PLoS ONE. 2013;8:e63206 pubmed publisher
DeChick A, Hetz R, Lee J, Speelman D. Increased Skeletal Muscle Fiber Cross-Sectional Area, Muscle Phenotype Shift, and Altered Insulin Signaling in Rat Hindlimb Muscles in a Prenatally Androgenized Rat Model for Polycystic Ovary Syndrome. Int J Mol Sci. 2020;21: pubmed publisher
Merdzo I, Rutkai I, Sure V, Katakam P, Busija D. Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels. Am J Physiol Heart Circ Physiol. 2019;317:H1086-H1092 pubmed publisher
Huddleston M, Xiao N, Both A, Gordon D. Single amino acid mutations in the Saccharomyces cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology. Cell Biol Int. 2019;: pubmed publisher
Polyzos A, Lee D, Datta R, Hauser M, Budworth H, Holt A, et al. Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice. Cell Metab. 2019;29:1258-1273.e11 pubmed publisher
Katsu Jiménez Y, Vázquez Calvo C, Maffezzini C, Halldin M, Peng X, Freyer C, et al. Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate. Diabetes. 2019;68:709-723 pubmed publisher
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, et al. Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 2019;7:14 pubmed publisher
Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, et al. Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019;11: pubmed publisher
Brown A, Meera P, Altindag B, Chopra R, Perkins E, Paul S, et al. MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proc Natl Acad Sci U S A. 2018;115:E12407-E12416 pubmed publisher
Wood B, Simon M, Galice S, Alim C, Ferrero M, Pinna N, et al. Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets. J Mol Cell Cardiol. 2018;125:18-28 pubmed publisher
Jády B, Ketele A, Kiss T. Dynamic association of human mRNP proteins with mitochondrial tRNAs in the cytosol. RNA. 2018;: pubmed publisher
Beck S, Guo L, Phensy A, Tian J, Wang L, Tandon N, et al. Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nat Commun. 2016;7:11483 pubmed publisher
product information
Product Type :
Antibody
Product Name :
ATP5A1 Monoclonal Antibody (7H10BD4F9)
Catalog # :
459240
Quantity :
100 µg
Price :
US 455
Clonality :
Monoclonal
Purity :
IgG fraction
Host :
Mouse
Reactivity :
Bovine, Human, Mouse, Rat
Applications :
Flow Cytometry: 1 µg/ml, Immunocytochemistry: 5 µg/mL, Western Blot: 1-2 µg/mL
Species :
Bovine, Human, Mouse, Rat
Clone :
7H10BD4F9
Isotype :
IgG2b, kappa
Storage :
4° C, do not freeze
Description :
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16.
Immunogen :
Bovine Complex V
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/ml, Immunocytochemistry: 5 µg/mL, Western Blot: 1-2 µg/mL
Aliases :
AI035633; AL022851; AL023067; alpha subunit ATP synthase isoform precursor (EC 3.6.1.34); ATP synthase alpha chain, mitochondrial; ATP synthase alpha subunit; ATP synthase alpha subunit precursor; ATP synthase F1 subunit alpha; ATP synthase subunit alpha heart isoform, mitochondrial; ATP synthase subunit alpha liver isoform, mitochondrial; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2; ATP sythase (F1-ATPase) alpha subunit; ATP5A; Atp5a1; ATP5A2; ATP5AL2; ATP5F1A; atp5fa1; ATPM; cardiac muscle ATP synthase H+ transporting mitochondrial F1 complex alpha subunit 1; COXPD22; D18Ertd206e; EGK_09658; epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; iso; MC5DN4; mitochondrial ATP synthase alpha chain; mitochondrial ATP synthase alpha subunit; mitochondrial ATP synthetase, oligomycin-resistant; mitochondrial H+-ATP synthase alpha subunit; modifier of Min 2; Mom2; OMR; ORM; zgc:154103
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA