SDHB Monoclonal Antibody (21A11AE7) | Invitrogen 459230 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SDHB Monoclonal Antibody (21A11AE7)

catalog :

459230

quantity :

100 µg

price :

US 456

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

21A11AE7

reactivity :

Chinese hamsters, human, mouse, rat, bovine, pigs , zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:500; fig 4b	Dai D, Danoviz M, Wiczer B, Laflamme M, Tian R. Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes. Stem Cells Int. 2017;2017:5153625 pubmed publisher
western blot; mouse; 1:1000; fig 5	Gali Ramamoorthy T, Laverny G, Schlagowski A, Zoll J, Messaddeq N, Bornert J, et al. The transcriptional coregulator PGC-1Î² controls mitochondrial function and anti-oxidant defence in skeletal muscles. Nat Commun. 2015;6:10210 pubmed publisher
western blot; mouse; 1:4000	Perdomini M, Belbellaa B, Monassier L, Reutenauer L, Messaddeq N, Cartier N, et al. Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia. Nat Med. 2014;20:542-7 pubmed publisher
western blot; rat; fig 9	Dun Y, Vargas J, Brot N, Finnemann S. Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells. Free Radic Biol Med. 2013;65:1340-1351 pubmed publisher
western blot; human; fig 11	Bancos I, Bida J, Tian D, Bundrick M, John K, Holte M, et al. High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma. PLoS ONE. 2013;8:e56827 pubmed publisher
western blot; mouse; fig 2	Kim S, Asaka M, Higashida K, Takahashi Y, Holloszy J, Han D. ?-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1? in skeletal muscle. Am J Physiol Endocrinol Metab. 2013;304:E844-52 pubmed publisher
	Van Haute L, Hendrick A, D Souza A, Powell C, Rebelo Guiomar P, Harbour M, et al. METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res. 2019;47:10267-10281 pubmed publisher
	Jia Y, Liu N, Viswakarma N, Sun R, Schipma M, Shang M, et al. PIMT/NCOA6IP Deletion in the Mouse Heart Causes Delayed Cardiomyopathy Attributable to Perturbation in Energy Metabolism. Int J Mol Sci. 2018;19: pubmed publisher
	Barrasso A, Tong X, Poche R. The mito::mKate2 mouse: A far-red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo. Genesis. 2018;56: pubmed publisher
	Lin A, Abbas S, Kim S, Ortega M, Bouamar H, Escobedo Y, et al. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun. 2015;6:7768 pubmed publisher
	MoratÃ³ L, Ruiz M, Boada J, Calingasan N, Galino J, Guilera C, et al. Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy. Cell Death Differ. 2015;22:1742-53 pubmed publisher
	Ussakli C, Ebaee A, Binkley J, Brentnall T, Emond M, Rabinovitch P, et al. Mitochondria and tumor progression in ulcerative colitis. J Natl Cancer Inst. 2013;105:1239-48 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SDHB Monoclonal Antibody (21A11AE7)

Catalog # :

459230

Quantity :

100 µg

Price :

US 456

Clonality :

Monoclonal

Purity :

IgG fraction

Host :

Mouse

Reactivity :

Bovine, Hamster, Human, Mouse, Porcine, Rat, Zebrafish

Applications :

Flow Cytometry: 1 µg per 10^6 cells, Immunocytochemistry: 1 µg/ml, Immunohistochemistry: Assay-dependent, Western Blot: 5 µg/mL

Species :

Bovine, Hamster, Human, Mouse, Porcine, Rat, Zebrafish

Clone :

21A11AE7

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Immunogen :

Bovine Heart Complex II, with traces of Complex III.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg per 10^6 cells, Immunocytochemistry: 1 µg/ml, Immunohistochemistry: Assay-dependent, Western Blot: 5 µg/mL

Aliases :

0710008N11Rik; CWS2; fj46d06; FLJ92337; I79_022285; Ip; iron-sulfur subunit; iron-sulfur subunit of complex II; OTTHUMP00000044624; PGL4; SDH; SDH1; SDH2; Sdhb; SDHB protein; SDHB; sdhB; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex iron sulfur subunit B; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip); succinate dehydrogenase Ip subunit; succinate dehydrogenase iron-protein subunit; wu:fj46d06

more info or order :

Invitrogen product webpage