MTCO2 Monoclonal Antibody (4B12A5) | Invitrogen 459150 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MTCO2 Monoclonal Antibody (4B12A5)

catalog :

459150

quantity :

100 µg

price :

US 401

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B12A5

reactivity :

Saccharomycetales, Saccharomyces cerevisiae S288C

application :

western blot

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; Saccharomycetales; 1:1000; fig 5	Chatenay Lapointe M, Shadel G. Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. PLoS ONE. 2011;6:e20441 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MTCO2 Monoclonal Antibody (4B12A5)

Catalog # :

459150

Quantity :

100 µg

Price :

US 401

Clonality :

Monoclonal

Purity :

IgG fraction

Host :

Mouse

Reactivity :

Yeast

Applications :

Western Blot: 2 µg/mL

Species :

Yeast

Clone :

4B12A5

Isotype :

IgG2a, kappa

Storage :

4° C, do not freeze

Description :

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [UniProt]

Immunogen :

Yeast cytochrome c oxidase subunit II

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2 µg/mL

Aliases :

ACI60_gp02; Co2; COII; COX2; COXII; cyclooxygenase; cytchrome c oxidase sububnit 2; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II; mitochondrially encoded cytochrome c oxidase II; Mtco2; MT-CO2; OXI1; OXII; Q0250

more info or order :

Invitrogen product webpage