product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
UQCRC1 Monoclonal Antibody (16D10AD9AH5)
catalog :
459140
quantity :
100 µg
price :
US 454
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
16D10AD9AH5
reactivity :
human, mouse, rat, bovine
application :
western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 38
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2000; loading ...; fig 4??s3b
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, et al. Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. elife. 2021;10: pubmed publisher
  • western blot; human; 1:5000
Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, et al. Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep. 2021;35:109024 pubmed publisher
  • western blot; mouse; 1:2000; fig s7e
Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, et al. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun. 2020;11:4150 pubmed publisher
  • western blot; mouse; loading ...; fig s3d
Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, et al. Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse. Sci Adv. 2019;5:eaav9824 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6e
Merdzo I, Rutkai I, Sure V, McNulty C, Katakam P, Busija D. Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes. J Vasc Res. 2017;54:1-12 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig s6c
Cao L, Riascos Bernal D, Chinnasamy P, Dunaway C, Hou R, Pujato M, et al. Control of mitochondrial function and cell growth by the atypical cadherin Fat1. Nature. 2016;539:575-578 pubmed publisher
  • western blot; human; loading ...
Stroud D, Surgenor E, Formosa L, Reljic B, Frazier A, Dibley M, et al. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature. 2016;538:123-126 pubmed publisher
  • western blot; human; loading ...; fig 6a
Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork Geleta A, Blecha J, Endaya B, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer. Antioxid Redox Signal. 2017;26:84-103 pubmed publisher
  • western blot; human; loading ...; fig 2b
Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
  • western blot; mouse; 1:20,000; fig s6
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, et al. ASK1 signalling regulates brown and beige adipocyte function. Nat Commun. 2016;7:11158 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Merdzo I, Rutkai I, Tokés T, Sure V, Katakam P, Busija D. The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats. Am J Physiol Heart Circ Physiol. 2016;310:H830-8 pubmed publisher
  • western blot; human; fig 7
Martínez Zamora A, Meseguer S, Esteve J, Villarroya M, Aguado C, Enríquez J, et al. Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier. PLoS ONE. 2015;10:e0144273 pubmed publisher
  • western blot; rat; 1:1000
Rutkai I, Dutta S, Katakam P, Busija D. Dynamics of enhanced mitochondrial respiration in female compared with male rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2015;309:H1490-500 pubmed publisher
  • western blot; mouse
Brandauer J, Andersen M, Kellezi H, Risis S, Frøsig C, Vienberg S, et al. AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD. Front Physiol. 2015;6:85 pubmed publisher
  • western blot; mouse
Zou P, Liu L, Zheng L, Liu L, Stoneman R, Cho A, et al. Targeting FoxO1 with AS1842856 suppresses adipogenesis. Cell Cycle. 2014;13:3759-67 pubmed publisher
  • western blot; rat; 1:5000
Alaimo A, Gorojod R, Beauquis J, Muñoz M, Saravia F, Kotler M. Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PLoS ONE. 2014;9:e91848 pubmed publisher
  • western blot; mouse; fig 1
Bakkar N, Ladner K, Canan B, Liyanarachchi S, Bal N, Pant M, et al. IKK? and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism. J Cell Biol. 2012;196:497-511 pubmed publisher
  • western blot; rat; fig 5
Alaimo A, Gorojod R, Kotler M. The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells. Neurochem Int. 2011;59:297-308 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 1
Lauritzen K, Cheng C, Wiksen H, Bergersen L, Klungland A. Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair (Amst). 2011;10:639-53 pubmed publisher
Formosa L, Reljic B, Sharpe A, Hock D, Muellner Wong L, Stroud D, et al. Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Swovick K, Firsanov D, Welle K, Hryhorenko J, Wise J, George C, et al. Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands. Mol Cell Proteomics. 2021;20:100041 pubmed publisher
Borna N, Kishita Y, Sakai N, Hamada Y, Kamagata K, Kohda M, et al. Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL. Genes (Basel). 2020;11: pubmed publisher
Hattori K, Wakatsuki H, Sakauchi C, Furutani S, Sugawara S, Hatta T, et al. β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes. PLoS ONE. 2020;15:e0232645 pubmed publisher
Elouej S, Harhouri K, Le Mao M, Baujat G, Nampoothiri S, Kayserili H, et al. Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology. Nat Commun. 2020;11:4589 pubmed publisher
Kishita Y, Shimura M, Kohda M, Akita M, Imai Okazaki A, Yatsuka Y, et al. A novel homozygous variant in MICOS13/QIL1 causes hepato-encephalopathy with mitochondrial DNA depletion syndrome. Mol Genet Genomic Med. 2020;8:e1427 pubmed publisher
Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu J, Trifunovic A, et al. The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis. Mol Cell Proteomics. 2020;19:1330-1345 pubmed publisher
Timper K, Del Río Martín A, Cremer A, Bremser S, Alber J, Giavalisco P, et al. GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020;31:1189-1205.e13 pubmed publisher
Formosa L, Muellner Wong L, Reljic B, Sharpe A, Jackson T, Beilharz T, et al. Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I. Cell Rep. 2020;31:107541 pubmed publisher
Sugawara S, Kanamaru Y, Sekine S, Maekawa L, Takahashi A, Yamamoto T, et al. The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1. J Biol Chem. 2020;295:5588-5601 pubmed publisher
Merdzo I, Rutkai I, Sure V, Katakam P, Busija D. Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels. Am J Physiol Heart Circ Physiol. 2019;317:H1086-H1092 pubmed publisher
Kovalchuke L, Mosharov E, Levy O, Greene L. Stress-induced phospho-ubiquitin formation causes parkin degradation. Sci Rep. 2019;9:11682 pubmed publisher
Deng J, Guo Y, Yuan F, Chen S, Yin H, Jiang X, et al. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening. Autophagy. 2019;:1-15 pubmed publisher
Timper K, Paeger L, Sánchez Lasheras C, Varela L, Jais A, Nolte H, et al. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 2018;25:383-397.e10 pubmed publisher
Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid C, et al. CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep. 2018;19: pubmed publisher
Boutoual R, Meseguer S, Villarroya M, Martin Hernandez E, Errami M, Martin M, et al. Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep. 2018;8:1163 pubmed publisher
Shintaku J, Peterson J, Talbert E, Gu J, Ladner K, Williams D, et al. MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-?B. Cell Rep. 2016;17:514-526 pubmed publisher
Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016;17:953-64 pubmed publisher
Genin E, Plutino M, Bannwarth S, Villa E, Cisneros Barroso E, Roy M, et al. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. EMBO Mol Med. 2016;8:58-72 pubmed publisher
product information
Product Type :
Antibody
Product Name :
UQCRC1 Monoclonal Antibody (16D10AD9AH5)
Catalog # :
459140
Quantity :
100 µg
Price :
US 454
Clonality :
Monoclonal
Purity :
IgG fraction
Host :
Mouse
Reactivity :
Bovine, Human, Mouse, Rat
Applications :
Flow Cytometry: 1 µg/10^6 cells, Immunocytochemistry: 1:50, Western Blot: 0.5 µg/mL
Species :
Bovine, Human, Mouse, Rat
Clone :
16D10AD9AH5
Isotype :
IgG1, kappa
Storage :
4° C, do not freeze
Description :
UQCRC1 encodes a product that is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Immunogen :
Bovine Complex III
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/10^6 cells, Immunocytochemistry: 1:50, Western Blot: 0.5 µg/mL
Aliases :
1110032G10Rik; Complex III subunit 1; core protein I; Cytochrome b-c1 complex subunit 1, mitochondrial; D3S3191; hypothetical protein MGC73404; QCR1; ubiquinol--cytochrome c reductase; ubiquinol-cytochrome c reductase core I protein; ubiquinol-cytochrome c reductase core protein 1; ubiquinol-cytochrome c reductase core protein I; ubiquinol-cytochrome-c reductase complex core protein 1; UQCR1; Uqcrc1; UQCRC1 protein; zgc:73404; zgc:85750
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA