COX5B Monoclonal Antibody (16H12H9) | Invitrogen 459110 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

COX5B Monoclonal Antibody (16H12H9)

catalog :

459110

quantity :

100 µg

price :

US 420

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16H12H9

reactivity :

human, mouse, rat, bovine

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 6b	Schatton D, Pla Martín D, Marx M, Hansen H, Mourier A, Nemazanyy I, et al. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017;216:675-693 pubmed publisher
western blot; mouse; fig 5	Korwitz A, Merkwirth C, Richter Dennerlein R, TrÃ¶der S, Sprenger H, QuirÃ³s P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
	Timper K, Del Río Martín A, Cremer A, Bremser S, Alber J, Giavalisco P, et al. GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020;31:1189-1205.e13 pubmed publisher
	Timper K, Paeger L, Sánchez Lasheras C, Varela L, Jais A, Nolte H, et al. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 2018;25:383-397.e10 pubmed publisher

product information

Product Type :

Antibody

Product Name :

COX5B Monoclonal Antibody (16H12H9)

Catalog # :

459110

Quantity :

100 µg

Price :

US 420

Clonality :

Monoclonal

Purity :

Ammonium sulfate precipitation

Host :

Mouse

Reactivity :

Bovine, Human, Mouse, Rat

Applications :

Flow Cytometry: 1 µg per 10^6 cells, Western Blot: 1.0 µg/mL

Species :

Bovine, Human, Mouse, Rat

Clone :

16H12H9

Isotype :

IgG2b, kappa

Storage :

4° C, do not freeze

Description :

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. Found in the inner mitochondrial membrane, COX5 is the heme A-containing chain of the oxidase family that converts one molecule of oxygen and four molecules of hydrogen to two molecules of water. Two isoforms of COX5 exist, COX5a and COX5b. When oxygen levels within the cell are high, transcription of COX5a (the aerobic isoform) is up-regulated as the rate of cellular respiration increases. Conversely, when oxygen levels are low, COX5b (the hypoxic isoform) transcription increases and functions to maximize the turnover rate of the COX apoenzyme.

Immunogen :

Bovine Complex IV (native holoenzyme protein, purified from heart)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg per 10^6 cells, Western Blot: 1.0 µg/mL

Aliases :

COX5B; COXVB; cytochrome c oxidase polypeptide Vb; cytochrome c oxidase polypeptide VB, mitochondrial; cytochrome c oxidase polypeptide VIa; cytochrome c oxidase precursor (EC 1.9.3.1); cytochrome c oxidase subunit 5B; cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase subunit Vb; cytochrome c oxidase subunit VIA*

more info or order :

Invitrogen product webpage