Mouse RELM beta Recombinant Protein, PeproTech | Invitrogen 450-26B-1MG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Mouse RELM beta Recombinant Protein, PeproTech

catalog :

450-26B-1MG

quantity :

1 mg

price :

US 3480.00

citations: 13

Reference
LeMessurier K, Palipane M, Tiwary M, Gavin B, Samarasinghe A. Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta. Sci Rep. 2018;8:7061 pubmed publisher
Chellappa K, Deol P, Evans J, Vuong L, Chen G, BrianÃ§on N, et al. Opposing roles of nuclear receptor HNF4Î± isoforms in colitis and colitis-associated colon cancer. elife. 2016;5: pubmed publisher
Steinbrecher K, Harmel Laws E, Garin Laflam M, Mann E, Bezerra L, Hogan S, et al. Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol. 2011;186:7205-14 pubmed publisher
Herbert D, Yang J, Hogan S, Groschwitz K, Khodoun M, Munitz A, et al. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med. 2009;206:2947-57 pubmed publisher
Nair M, Du Y, Perrigoue J, Zaph C, Taylor J, Goldschmidt M, et al. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med. 2009;206:937-52 pubmed publisher
Nair M, Guild K, Du Y, Zaph C, Yancopoulos G, Valenzuela D, et al. Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. J Immunol. 2008;181:4709-15 pubmed
Barnes S, Vidrich A, Wang M, Wu G, Cominelli F, Rivera Nieves J, et al. Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. J Immunol. 2007;179:7012-20 pubmed
Mishra A, Wang M, Schlotman J, Nikolaidis N, Debrosse C, Karow M, et al. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol. 2007;293:L305-13 pubmed
McVay L, Keilbaugh S, Wong T, Kierstein S, Shin M, Lehrke M, et al. Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest. 2006;116:2914-23 pubmed
Fujinami A, Ohta K, Matsui H, Kitada N, Kitaura Y, Kawahara Y, et al. Resistin concentrations in murine adipose tissue and serum measured by a new enzyme immunoassay. Obesity (Silver Spring). 2006;14:199-205 pubmed
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, et al. Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet. J Biol Chem. 2005;280:42016-25 pubmed
Wang M, Shin M, Knight P, Artis D, Silberg D, Suh E, et al. Regulation of RELM/FIZZ isoform expression by Cdx2 in response to innate and adaptive immune stimulation in the intestine. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1074-83 pubmed
Artis D, Wang M, Keilbaugh S, He W, Brenes M, Swain G, et al. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A. 2004;101:13596-600 pubmed

product information

Product Type :

Protein

Product Name :

Mouse RELM beta Recombinant Protein, PeproTech

Catalog # :

450-26B-1MG

Quantity :

1 mg

Price :

US 3480.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Storage :

-20 C

Description :

Adipose tissue is an energy reserve that is strictly regulated in animals. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin. Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine that is specifically secreted by adipocytes. While the function of resistin is not well understood, it appears to have key paracrine roles and has a suggested role in type 2 diabetes. Studies show that in obese, diabetic mice the levels of serum resistin are increased, which has an antagonistic effect on insulin. Additional studies have shown that resistin causes insulin resistance and glucose intolerance in mice. Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Studies show that the coactivators CBP and p300, which have been shown to display histone acetyltransferase (HAT) activity, abundantly acetylate the histones at the resistin promoter suggesting their role in activating chromatin for resistin transcription. Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

9030012B21Rik; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2; CCRG; Colon and small intestine-specific cysteine-rich protein; colon carcinoma-related gene protein; cysteine-rich secreted A12-alpha-like protein 1; cysteine-rich secreted protein A12-alpha-like 1; Cysteine-rich secreted protein A12-beta; cysteine-rich secreted protein FIZZ2; FIZZ1; Fizz2; found in inflammatory zone 1; found in inflammatory zone 2; HXCP2; Relmb; RELMbeta; RELM-beta; resistin like beta; resistin-like beta; resistin-like molecule beta; RETNL2; RETNLB; RSNB; UNQ408/PRO770; XCP2; Xcp3