Human Osteoprotegerin (TNFRSF11B) Recombinant Protein, PeproTech | Invitrogen 450-14-250UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human Osteoprotegerin (TNFRSF11B) Recombinant Protein, PeproTech

catalog :

450-14-250UG

quantity :

250 ug

price :

US 608.00

citations: 21

Reference
Zhao S, Liu H, Chen J, Qian D, Kong F, Jie J, et al. Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way. J Bone Miner Res. 2020;: pubmed publisher
Brito H, Radulski D, Wilhelms D, Stojakovic A, Brito L, Gil da Costa R, et al. Immune-mediated febrile response in female rats: Role of central hypothalamic mediators. Sci Rep. 2020;10:4073 pubmed publisher
Gooding S, Olechnowicz S, Morris E, Armitage A, Arezes J, Frost J, et al. Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease. Nat Commun. 2019;10:4533 pubmed publisher
Ochiai N, Nakachi Y, Yokoo T, Ichihara T, Eriksson T, Yonemoto Y, et al. Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. Commun Biol. 2019;2:86 pubmed publisher
Stephenson S, Care M, Fan I, Zougman A, Westhead D, Doody G, et al. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. J Immunol. 2019;202:1287-1300 pubmed publisher
Ai L, Sun C, Zhang L, Zhou S, Chu Z, Qin Y, et al. Inhibition of BDNF in multiple myeloma blocks osteoclastogenesis via down-regulated stroma-derived RANKL expression both in vitro and in vivo. PLoS ONE. 2012;7:e46287 pubmed publisher
Martínez Calatrava M, Prieto Potin I, Roman Blas J, Tardio L, Largo R, Herrero Beaumont G. RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis. Arthritis Res Ther. 2012;14:R149 pubmed publisher
Zhao B, Grimes S, Li S, Hu X, Ivashkiv L. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med. 2012;209:319-34 pubmed publisher
Fuller K, Ross J, Szewczyk K, Moss R, Chambers T. Bone is not essential for osteoclast activation. PLoS ONE. 2010;5: pubmed publisher
Knowles H, Cleton Jansen A, Korsching E, Athanasou N. Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J. 2010;24:4648-59 pubmed publisher
Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, et al. Central control of fever and female body temperature by RANKL/RANK. Nature. 2009;462:505-9 pubmed publisher
Barbaroux J, Beleut M, Brisken C, Mueller C, Groves R. Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation. J Immunol. 2008;181:1103-8 pubmed
Singh K, Rahman M, Son J, Kim K, Shim Y. An amperometric immunosensor for osteoproteogerin based on gold nanoparticles deposited conducting polymer. Biosens Bioelectron. 2008;23:1595-601 pubmed publisher
Zhu J, Jia X, Xiao G, Kang Y, Partridge N, Qin L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem. 2007;282:26656-64 pubmed
Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, et al. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest. 2006;116:1525-34 pubmed
Frick K, LaPlante K, Bushinsky D. RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro. Am J Physiol Renal Physiol. 2005;289:F1005-11 pubmed
Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, et al. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J Exp Med. 2004;200:601-11 pubmed
Nakano K, Okada Y, Saito K, Tanaka Y. Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. Arthritis Rheum. 2004;50:2450-8 pubmed
Cheng X, Kinosaki M, Takami M, Choi Y, Zhang H, Murali R. Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo. J Biol Chem. 2004;279:8269-77 pubmed
Leslie D, Vincent M, Spada F, Das H, Sugita M, Morita C, et al. CD1-mediated gamma/delta T cell maturation of dendritic cells. J Exp Med. 2002;196:1575-84 pubmed
Vincent M, Leslie D, Gumperz J, Xiong X, Grant E, Brenner M. CD1-dependent dendritic cell instruction. Nat Immunol. 2002;3:1163-8 pubmed

product information

Product Type :

Protein

Product Name :

Human Osteoprotegerin (TNFRSF11B) Recombinant Protein, PeproTech

Catalog # :

450-14-250UG

Quantity :

250 ug

Price :

US 608.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11B; MGC29565; OCIF; Opg; osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; soluble OPG; soluble Osteoprotegerin; sOPG; TNF receptor superfamily member 11b; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b; tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)