ELK1 Monoclonal Antibody (3H6D12) | Invitrogen 45-8700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ELK1 Monoclonal Antibody (3H6D12)

catalog :

45-8700

quantity :

100µg

price :

331 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3H6D12

reactivity :

human, mouse, rat, cow

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; fig 4	Fukuda A, Shimada M, Nakadai T, Nishimura K, Hisatake K. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. PLoS ONE. 2013;8:e72496 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ELK1 Monoclonal Antibody (3H6D12)

Catalog # :

45-8700

Catalog # :

458700

Quantity :

100µg

Price :

331 USD

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human, Mouse, Non-human primate, Rat

Applications :

Immunofluorescence: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 2 µg/mL

Species :

Bovine, Human, Mouse, Non-human primate, Rat

Clone :

3H6D12

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.

Immunogen :

Truncated recombinant protein derived from human ELK1 protein

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 2 µg/mL

Aliases :

ETS domain-containing protein Elk-1, ELK1