This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-10 Monoclonal Antibody (JES5-16E3), PerCP-Cyanine5.5, eBioscience
catalog :
45-7101-80
quantity :
25 ug
price :
US 181.00
clonality :
monoclonal
host :
rat
conjugate :
PerCP/Cy5.5
clone name :
JES5-16E3

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 180
Reference
Liu C, Guo S, Liu R, Guo M, Wang Q, Chai Z, et al. Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis. Neural Regen Res. 2024;19:671-679 pubmed publisher
Zhou J, Wang H, Shu T, Wang J, Yang W, Li J, et al. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience. 2023;26:107626 pubmed publisher
Jianyi D, Haili G, Bo Y, Meiqin Y, Baoyou H, Haoran H, et al. Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer. Cancer Immunol Immunother. 2023;72:73-85 pubmed publisher
Zhu K, Wang Y, Sarlus H, Geng K, Nutma E, Sun J, et al. Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Rep. 2022;23:e54499 pubmed publisher
Ma S, Patel S, Abe Y, Chen N, Patel P, Cho B, et al. RORγt phosphorylation protects against T cell-mediated inflammation. Cell Rep. 2022;38:110520 pubmed publisher
Medina Buelvas D, Rodr xed guez Sosa M, Vega L. Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi. Pathogens. 2021;10: pubmed publisher
Lin C, Chen M, Lin L, Christian D, Min B, Hunter C, et al. Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes. J Exp Med. 2021;218: pubmed publisher
Tong L, Hao H, Zhang Z, Lv Y, Liang X, Liu Q, et al. Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota. Theranostics. 2021;11:8570-8586 pubmed publisher
Vernet R, Charrier E, Cosset E, Fi xe8 vre S, Tomasello U, Grogg J, et al. Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model. Vaccines (Basel). 2021;9: pubmed publisher
Chen J, Ding Y, Huang F, Lan R, Wang Z, Huang W, et al. Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells. Oncol Lett. 2021;21:409 pubmed publisher
Kedzierska A, Lorek D, Slawek A, Chelmonska Soyta A. Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings. Sci Rep. 2020;10:10531 pubmed publisher
Miao W, Zhao Y, Huang Y, Chen D, Luo C, Su W, et al. IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury. J Immunol. 2020;204:1486-1498 pubmed publisher
Cai W, Dai X, Chen J, Zhao J, Xu M, Zhang L, et al. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI Insight. 2019;4: pubmed publisher
Cruz L, Hashemifar S, Wu C, Cho S, Nguyen D, Lin L, et al. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J Clin Invest. 2017;127:530-542 pubmed publisher
Alrefai H, Muhammad K, Rudolf R, Pham D, Klein Hessling S, Patra A, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724 pubmed publisher
Tian Y, Kuo C, Akbari O, Ou J. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016;44:1204-14 pubmed publisher
Singh S, Vedi S, Samrat S, Li W, Kumar R, Agrawal B. Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS ONE. 2016;11:e0146404 pubmed publisher
Roberts R, Eitas T, Byrne J, Johnson B, Short P, McKinnon K, et al. Towards programming immune tolerance through geometric manipulation of phosphatidylserine. Biomaterials. 2015;72:1-10 pubmed publisher
Kratochvill F, Gratz N, Qualls J, Van De Velde L, Chi H, Kovarik P, et al. Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner. Cancer Res. 2015;75:3054-64 pubmed publisher
Song N, Gao L, Qiu H, Huang C, Cheng H, Zhou H, et al. Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant. Int J Mol Med. 2015;36:139-49 pubmed publisher
Lewis M, De Leenheer E, Fishman S, Siew L, Gross G, Wong F. A reproducible method for the expansion of mouse CD8+ T lymphocytes. J Immunol Methods. 2015;417:134-8 pubmed publisher
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Sánchez Vallecillo M, Ullio Gamboa G, Palma S, Harman M, Chiodetti A, Moron G, et al. Adjuvant activity of CpG-ODN formulated as a liquid crystal. Biomaterials. 2014;35:2529-42 pubmed publisher
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice. Metab Brain Dis. 2014;29:59-73 pubmed publisher
Wei H, Zhao L, Li W, Fan K, Qian W, Hou S, et al. Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin. PLoS ONE. 2013;8:e84927 pubmed publisher
Kim J, Stott R, Soohoo J, Lee K, Zhao G, Yeh H, et al. Elevated levels of interferon-? production by memory T cells do not promote transplant tolerance resistance in aged recipients. PLoS ONE. 2013;8:e82856 pubmed publisher
Gower R, Boehler R, Azarin S, Ricci C, Leonard J, Shea L. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 2014;35:2024-31 pubmed publisher
Dey M, Chang A, Wainwright D, Ahmed A, Han Y, Balyasnikova I, et al. Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model. J Neuroimmunol. 2014;266:33-42 pubmed publisher
Holan V, Zajicova A, Javorkova E, Trosan P, Chudícková M, Pavlikova M, et al. Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells. Immunology. 2014;141:577-86 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Kling J, Mack M, Korner H. The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis. PLoS ONE. 2013;8:e79098 pubmed publisher
Banerjee A, Wang J, Bodhankar S, Vandenbark A, Murphy S, Offner H. Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice. Transl Stroke Res. 2013;4:554-63 pubmed
Lee H, Jang M, Kim J, Hong C, Lee E, Jeun E, et al. Ulmus davidiana var. japonica Nakai upregulates eosinophils and suppresses Th1 and Th17 cells in the small intestine. PLoS ONE. 2013;8:e76716 pubmed publisher
Kamata M, Tada Y, Mitsui A, Shibata S, Miyagaki T, Asano Y, et al. ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells. Am J Pathol. 2013;183:1731-1739 pubmed publisher
Corsetti P, de Almeida L, Carvalho N, Azevedo V, Silva T, Teixeira H, et al. Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS ONE. 2013;8:e74729 pubmed publisher
Gangaplara A, Massilamany C, Steffen D, Reddy J. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand. J Neuroimmunol. 2013;263:98-107 pubmed publisher
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1. J Neuroinflammation. 2013;10:111 pubmed publisher
Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, et al. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013;191:3614-23 pubmed publisher
Maseda D, Candando K, Smith S, Kalampokis I, Weaver C, Plevy S, et al. Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-?+CD4+ T cell numbers during colitis development in mice. J Immunol. 2013;191:2780-2795 pubmed publisher
Mineo S, Niikura M, Inoue S, Kuroda M, Kobayashi F. Development of severe pathology in immunized pregnant mice challenged with lethal malaria parasites. Infect Immun. 2013;81:3865-71 pubmed publisher
Leepiyasakulchai C, Taher C, Chuquimia O, Mazurek J, Söderberg Naucler C, Fernández C, et al. Infection rate and tissue localization of murine IL-12p40-producing monocyte-derived CD103(+) lung dendritic cells during pulmonary tuberculosis. PLoS ONE. 2013;8:e69287 pubmed publisher
de Kouchkovsky D, Esensten J, Rosenthal W, Morar M, Bluestone J, Jeker L. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J Immunol. 2013;191:1594-605 pubmed publisher
Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H, Serada S, et al. ifn-?-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 2013;4:e710 pubmed publisher
Zhang R, Li Q, Chuang P, Lu G, Liu R, Yang J, et al. Regulation of pathogenic Th17 cell differentiation by IL-10 in the development of glomerulonephritis. Am J Pathol. 2013;183:402-12 pubmed publisher
Hu Z, Zhang W, Usherwood E. Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect. J Immunol. 2013;191:312-22 pubmed publisher
Bae J, Koo J, Kim S, Park T, Kim M. Ginsenoside Rp1 Exerts Anti-inflammatory Effects via Activation of Dendritic Cells and Regulatory T Cells. J Ginseng Res. 2012;36:375-82 pubmed publisher
Thomas D, Wong F, Zaccone P, Green E, Wallberg M. Protection of islet grafts through transforming growth factor-?-induced tolerogenic dendritic cells. Diabetes. 2013;62:3132-42 pubmed publisher
Kalli F, Machiorlatti R, Battaglia F, Parodi A, Conteduca G, Ferrera F, et al. Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice. J Transl Med. 2013;11:120 pubmed publisher
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab Brain Dis. 2013;28:375-86 pubmed publisher
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, et al. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol. 2013;94:563-73 pubmed publisher
Natividad K, Junankar S, Mohd Redzwan N, Nair R, Wirasinha R, King C, et al. Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLoS ONE. 2013;8:e57469 pubmed publisher
Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, et al. Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis. Infect Immun. 2013;81:2104-11 pubmed publisher
Gahring L, Enioutina E, Myers E, Spangrude G, Efimova O, Kelley T, et al. Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. PLoS ONE. 2013;8:e57481 pubmed publisher
Schreiner J, Kretschmer D, Klenk J, Otto M, Bühring H, Stevanovic S, et al. Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol. 2013;190:3417-26 pubmed publisher
Breser M, Motrich R, Sanchez L, Mackern Oberti J, Rivero V. Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome. J Immunol. 2013;190:3121-33 pubmed publisher
Kathania M, Zadeh M, Lightfoot Y, Roman R, Sahay B, Abbott J, et al. Colonic immune stimulation by targeted oral vaccine. PLoS ONE. 2013;8:e55143 pubmed publisher
Yamamoto M, Seki Y, Iwai K, Ko I, Martin A, Tsuji N, et al. Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013;61:831-41 pubmed publisher
Horikawa M, Weimer E, DiLillo D, Venturi G, Spolski R, Leonard W, et al. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol. 2013;190:1158-68 pubmed publisher
Gleimer M, von Boehmer H, Kreslavsky T. PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function. Front Immunol. 2012;3:374 pubmed publisher
Wan W, Lionakis M, Liu Q, Roffe E, Murphy P. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. Cardiovasc Res. 2013;97:580-8 pubmed publisher
Kerzerho J, Maazi H, Speak A, Szely N, Lombardi V, Khoo B, et al. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. J Allergy Clin Immunol. 2013;131:1048-57, 1057.e1-2 pubmed publisher
Yoshizaki A, Miyagaki T, DiLillo D, Matsushita T, Horikawa M, Kountikov E, et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature. 2012;491:264-8 pubmed publisher
Aviszus K, Macleod M, Kirchenbaum G, Detanico T, Heiser R, St Clair J, et al. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol. 2012;189:4275-83 pubmed publisher
Ishii H, Jin X, Ueno M, Tanabe S, Kubo T, Serada S, et al. Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Cell Death Dis. 2012;3:e363 pubmed publisher
Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel C, et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 2013;6:177-88 pubmed publisher
Gangaplara A, Massilamany C, Brown D, Delhon G, Pattnaik A, Chapman N, et al. Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice. Clin Immunol. 2012;144:237-49 pubmed publisher
DePaolo R, Kamdar K, Khakpour S, Sugiura Y, Wang W, Jabri B. A specific role for TLR1 in protective T(H)17 immunity during mucosal infection. J Exp Med. 2012;209:1437-44 pubmed publisher
Carrier Y, Whitters M, Miyashiro J, LaBranche T, Ramon H, Benoit S, et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol. 2012;42:1393-404 pubmed publisher
Chen Y, Bodhankar S, Murphy S, Vandenbark A, Alkayed N, Offner H. Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice. Metab Brain Dis. 2012;27:487-93 pubmed publisher
Donners M, Wolfs I, Stöger L, van der Vorst E, Pöttgens C, Heymans S, et al. Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice. PLoS ONE. 2012;7:e35877 pubmed publisher
Altin J, Goodnow C, Cook M. IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. J Immunol. 2012;188:5478-88 pubmed publisher
Yurchenko E, Shio M, Huang T, Da Silva Martins M, Szyf M, Levings M, et al. Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE. 2012;7:e35572 pubmed publisher
Diao J, Mikhailova A, Tang M, Gu H, Zhao J, Cattral M. Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells. Blood. 2012;119:4919-27 pubmed publisher
Iwata Y, Boström E, Menke J, Rabacal W, Morel L, Wada T, et al. Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice. J Immunol. 2012;188:4568-80 pubmed publisher
Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, et al. Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. J Biol Chem. 2012;287:17100-8 pubmed publisher
Attridge K, Wang C, Wardzinski L, Kenefeck R, Chamberlain J, Manzotti C, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood. 2012;119:4656-64 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney N, Schuijs M, et al. IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS ONE. 2012;7:e32371 pubmed publisher
Liu J, Liu Z, Zhang X, Shi Y, Talebian F, Carl J, et al. Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis. J Immunol. 2012;188:3099-106 pubmed publisher
Wang H, Yeh C, Iwamoto T, Satsu H, Shimizu M, Totsuka M. Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway. J Agric Food Chem. 2012;60:2171-8 pubmed publisher
Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
Tian L, De Hertogh G, Fedeli M, Staats K, Schonefeldt S, Humblet Baron S, et al. Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice. J Autoimmun. 2012;38:39-48 pubmed publisher
Freitas do Rosário A, Lamb T, Spence P, Stephens R, Lang A, Roers A, et al. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol. 2012;188:1178-90 pubmed publisher
Maseda D, Smith S, DiLillo D, Bryant J, Candando K, Weaver C, et al. Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol. 2012;188:1036-48 pubmed publisher
Roffê E, Rothfuchs A, Santiago H, Marino A, Ribeiro Gomes F, Eckhaus M, et al. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. J Immunol. 2012;188:649-60 pubmed publisher
Tsakiri N, Papadopoulos D, Denis M, Mitsikostas D, Kollias G. TNFR2 on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE. Eur J Immunol. 2012;42:403-12 pubmed publisher
Massilamany C, Asojo O, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011;23:729-39 pubmed publisher
Berer K, Mues M, Koutrolos M, Rasbi Z, Boziki M, Johner C, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538-41 pubmed publisher
Tu Z, Li Y, Smith D, Sheibani N, Huang S, Kern T, et al. Retinal pericytes inhibit activated T cell proliferation. Invest Ophthalmol Vis Sci. 2011;52:9005-10 pubmed publisher
Yurchenko E, Levings M, Piccirillo C. CD4+ Foxp3+ regulatory T cells suppress ?? T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol. 2011;41:3455-66 pubmed publisher
Shin J, Park C. ELISPOT assay as a tool to study the effects of stem cells on cytokine secretion. Methods Mol Biol. 2012;792:105-14 pubmed publisher
Pongratz G, Melzer M, Straub R. The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis. Ann Rheum Dis. 2012;71:432-9 pubmed publisher
Massilamany C, Gangaplara A, Steffen D, Reddy J. Identification of novel mimicry epitopes for cardiac myosin heavy chain-? that induce autoimmune myocarditis in A/J mice. Cell Immunol. 2011;271:438-49 pubmed publisher
Weiss K, Christiaansen A, Fulton R, Meyerholz D, Varga S. Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol. 2011;187:3145-54 pubmed publisher
Rausch M, Hastings K. GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1. J Invest Dermatol. 2012;132:154-62 pubmed publisher
Poe J, Smith S, Haas K, Yanaba K, Tsubata T, Matsushita T, et al. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS ONE. 2011;6:e22464 pubmed publisher
Ganesh B, Bhattacharya P, Gopisetty A, Sheng J, Vasu C, Prabhakar B. IL-1? promotes TGF-?1 and IL-2 dependent Foxp3 expression in regulatory T cells. PLoS ONE. 2011;6:e21949 pubmed publisher
Goedecke A, Wobus M, Krech M, Münch N, Richter K, Hölig K, et al. Differential effect of platelet-rich plasma and fetal calf serum on bone marrow-derived human mesenchymal stromal cells expanded in vitro. J Tissue Eng Regen Med. 2011;5:648-54 pubmed publisher
Xiao Z, Mohamood A, Uddin S, Gutfreund R, Nakata C, Marshall A, et al. Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. Am J Pathol. 2011;179:725-32 pubmed publisher
Tian L, Altin J, Makaroff L, Franckaert D, Cook M, Goodnow C, et al. Foxp3? regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood. 2011;118:1845-53 pubmed publisher
Skripuletz T, Miller E, Grote L, Gudi V, Pul R, Voss E, et al. Lipopolysaccharide delays demyelination and promotes oligodendrocyte precursor proliferation in the central nervous system. Brain Behav Immun. 2011;25:1592-606 pubmed publisher
Kar U, Srivastava M, Andersson A, Baratelli F, Huang M, Kickhoefer V, et al. Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth. PLoS ONE. 2011;6:e18758 pubmed publisher
Tosiek M, Gruber A, Bader S, Mauel S, Hoymann H, Prettin S, et al. CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation. J Immunol. 2011;186:6106-18 pubmed publisher
Caccamo N, La Mendola C, Orlando V, Meraviglia S, Todaro M, Stassi G, et al. Differentiation, phenotype, and function of interleukin-17-producing human V?9V?2 T cells. Blood. 2011;118:129-38 pubmed publisher
Okamoto T, Saito T, Tabata Y, Uemoto S. Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,16 dimethyl PGE2 and PGE2-containing nanoscale hydrogels. Biomaterials. 2011;32:4925-35 pubmed publisher
Diao J, Zhao J, Winter E, Cattral M. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol. 2011;186:5058-67 pubmed publisher
Berretta F, St Pierre J, Piccirillo C, Stevenson M. IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol. 2011;186:4862-71 pubmed publisher
Coffelt S, Chen Y, Muthana M, Welford A, Tal A, Scholz A, et al. Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. J Immunol. 2011;186:4183-90 pubmed publisher
Bao Y, Han Y, Chen Z, Xu S, Cao X. IFN-?-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells. Eur J Immunol. 2011;41:657-68 pubmed publisher
Yanaba K, Yoshizaki A, Asano Y, Kadono T, Tedder T, Sato S. IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model. Am J Pathol. 2011;178:735-43 pubmed publisher
Kolbus D, Ramos O, Berg K, Persson J, Wigren M, Bjorkbacka H, et al. CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe?(/)? mice. BMC Immunol. 2010;11:58 pubmed publisher
Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, et al. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. J Immunol. 2011;186:113-20 pubmed publisher
Palmer M, Lee Y, Maynard C, Oliver J, Bikle D, Jetten A, et al. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem. 2011;286:997-1004 pubmed publisher
Diana J, Beaudoin L, Gautron A, Lehuen A. NKT and tolerance. Methods Mol Biol. 2011;677:193-206 pubmed publisher
Kastner L, Dwyer D, Qin F. Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells. J Immunol. 2010;185:5778-86 pubmed publisher
Wondimu Z, Santodomingo Garzon T, Le T, Swain M. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am J Pathol. 2010;177:2334-46 pubmed publisher
Piconese S, Pittoni P, Burocchi A, Gorzanelli A, Carè A, Tripodo C, et al. A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2. Eur J Immunol. 2010;40:2902-13 pubmed publisher
Nakatsukasa H, Tsukimoto M, Tokunaga A, Kojima S. Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly. Radiat Res. 2010;174:313-24 pubmed publisher
Lin P, Sun L, Thibodeaux S, Ludwig S, Vadlamudi R, Hurez V, et al. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol. 2010;185:2747-53 pubmed publisher
Matsushita T, Horikawa M, Iwata Y, Tedder T. Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J Immunol. 2010;185:2240-52 pubmed publisher
Darrah P, Hegde S, Patel D, Lindsay R, Chen L, Roederer M, et al. IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform. J Exp Med. 2010;207:1421-33 pubmed publisher
Vega Ramos J, Alari Pahissa E, Valle J, Carrasco Marin E, Esplugues E, Borras M, et al. CD69 limits early inflammatory diseases associated with immune response to Listeria monocytogenes infection. Immunol Cell Biol. 2010;88:707-15 pubmed publisher
Haas K, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, et al. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. J Immunol. 2010;184:4789-800 pubmed publisher
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed publisher
Niess J, Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol. 2010;184:2026-37 pubmed publisher
Tan A, Lam K. Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation. J Immunol. 2010;184:1849-57 pubmed publisher
Hondowicz B, Batheja A, Metzgar M, Caton A, Erikson J. ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice. J Autoimmun. 2010;34:460-8 pubmed publisher
Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed publisher
Sasajima N, Ogasawara T, Takemura N, Fujiwara R, Watanabe J, Sonoyama K. Role of intestinal Bifidobacterium pseudolongum in dietary fructo-oligosaccharide inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. Br J Nutr. 2010;103:539-48 pubmed publisher
Anderson C, Stumhofer J, Hunter C, Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J Immunol. 2009;183:4619-27 pubmed publisher
Kim S, Shen T, Min B. Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes. J Immunol. 2009;183:3033-9 pubmed publisher
Boudousquié C, Pellaton C, Barbier N, Spertini F. CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma. Clin Exp Allergy. 2009;39:1415-26 pubmed publisher
Locke N, Patterson S, Hamilton M, Sly L, Krystal G, Levings M. SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol. 2009;183:975-83 pubmed publisher
Liu X, Leerberg J, MacDonald K, Leggatt G, Frazer I. IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. J Immunol. 2009;183:51-8 pubmed publisher
Gebe J, Yue B, Unrath K, Falk B, Nepom G. Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol. 2009;183:59-65 pubmed publisher
Yanaba K, Bouaziz J, Matsushita T, Tsubata T, Tedder T. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009;182:7459-72 pubmed publisher
Fang C, Zhang X, Miwa T, Song W. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-15 pubmed publisher
Cuellar C, Wu W, Mendez S. The hookworm tissue inhibitor of metalloproteases (Ac-TMP-1) modifies dendritic cell function and induces generation of CD4 and CD8 suppressor T cells. PLoS Negl Trop Dis. 2009;3:e439 pubmed publisher
Shiokawa A, Tanabe K, Tsuji N, Sato R, Hachimura S. IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance. Immunol Lett. 2009;125:7-14 pubmed publisher
Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker P, et al. Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression. J Immunol. 2009;182:6508-16 pubmed publisher
Arakaki R, Nagaoka A, Ishimaru N, Yamada A, Yoshida S, Hayashi Y. Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background. Am J Pathol. 2009;174:1715-24 pubmed publisher
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
Spolski R, Kim H, Zhu W, Levy D, Leonard W. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol. 2009;182:2859-67 pubmed publisher
Ganesh B, Cheatem D, Sheng J, Vasu C, Prabhakar B. GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis. Int Immunol. 2009;21:269-82 pubmed publisher
Santodomingo Garzon T, Han J, Le T, Yang Y, Swain M. Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice. Hepatology. 2009;49:1267-76 pubmed publisher
Ribeiro de Almeida C, Heath H, Krpic S, Dingjan G, van Hamburg J, Bergen I, et al. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol. 2009;182:999-1010 pubmed
Lin Y, Wang W, Jin H, Zhong Y, Di J, Zeng S, et al. Comparison of murine thymic stromal lymphopoietin- and polyinosinic polycytidylic acid-mediated placental dendritic cell activation. J Reprod Immunol. 2009;79:119-28 pubmed publisher
Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher E. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253-60 pubmed publisher
Pacifico L, Marinho F, Fonseca C, Barsante M, Pinho V, Sales Junior P, et al. Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10. Infect Immun. 2009;77:98-107 pubmed publisher
Li Q, Xu B, Michie S, Rubins K, Schreriber R, McDevitt H. Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2008;105:12439-44 pubmed publisher
Godebu E, Summers Torres D, Lin M, Baaten B, Bradley L. Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells. J Immunol. 2008;181:1798-805 pubmed
Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, et al. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008;205:1381-93 pubmed publisher
Singh A, Carson W, Secor E, Guernsey L, Flavell R, Clark R, et al. Regulatory role of B cells in a murine model of allergic airway disease. J Immunol. 2008;180:7318-26 pubmed
Niikura M, Kamiya S, Kita K, Kobayashi F. Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium berghei NK65. J Immunol. 2008;180:6877-84 pubmed
Arens R, Wang P, Sidney J, Loewendorf A, Sette A, Schoenberger S, et al. Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response. J Immunol. 2008;180:6472-6 pubmed
Chen X, Priatel J, Chow M, Teh H. Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice. J Immunol. 2008;180:5973-82 pubmed
Batten M, Kljavin N, Li J, Walter M, De Sauvage F, Ghilardi N. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol. 2008;180:2752-6 pubmed
Jin R, Wang W, Yao J, Zhou Y, Qian X, Zhang J, et al. Characterization of the in vivo dynamics of medullary CD4+CD8- thymocyte development. J Immunol. 2008;180:2256-63 pubmed
Watte C, Nakamura T, Lau C, Ortaldo J, Stein Streilein J. Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance. J Leukoc Biol. 2008;83:928-35 pubmed publisher
Rankin A, Reed A, Oh S, Cozzo Picca C, Guay H, Larkin J, et al. CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis. J Immunol. 2008;180:833-41 pubmed
Pariwat P, Homvisasevongsa S, Muanprasat C, Chatsudthipong V. A natural plant-derived dihydroisosteviol prevents cholera toxin-induced intestinal fluid secretion. J Pharmacol Exp Ther. 2008;324:798-805 pubmed
Noguchi D, Wakita D, Tajima M, Ashino S, Iwakura Y, Zhang Y, et al. Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner. Int Immunol. 2007;19:1431-40 pubmed
Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008;38:417-29 pubmed
Denning T, Wang Y, Patel S, Williams I, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol. 2007;8:1086-94 pubmed
Kapp J, Honjo K, Kapp L, Goldsmith K, Bucy R. Antigen, in the presence of TGF-beta, induces up-regulation of FoxP3gfp+ in CD4+ TCR transgenic T cells that mediate linked suppression of CD8+ T cell responses. J Immunol. 2007;179:2105-14 pubmed
Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, et al. Induction of regulatory T cells by physiological level estrogen. J Cell Physiol. 2008;214:456-64 pubmed
Mutou Y, Ibuki Y, Kojima S. Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice. Photodermatol Photoimmunol Photomed. 2007;23:135-44 pubmed
Ordway D, Henao Tamayo M, Harton M, Palanisamy G, Troudt J, Shanley C, et al. The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation. J Immunol. 2007;179:522-31 pubmed
Puertas M, Carrillo J, Pastor X, Ampudia R, Alba A, Planas R, et al. Phenotype and functional characteristics of islet-infiltrating B-cells suggest the existence of immune regulatory mechanisms in islet milieu. Diabetes. 2007;56:940-9 pubmed
Popov S, Popova G, Paderin N, Koval O, Ovodova R, Ovodov Y. Preventative antiinflammatory effect of potamogetonan, a pectin from the common pondweed Potamogeton natans L. Phytother Res. 2007;21:609-14 pubmed
Zhou R, Wei H, Tian Z. NK3-like NK cells are involved in protective effect of polyinosinic-polycytidylic acid on type 1 diabetes in nonobese diabetic mice. J Immunol. 2007;178:2141-7 pubmed
Joetham A, Takeda K, Takada K, Taube C, Miyahara N, Matsubara S, et al. Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta. J Immunol. 2007;178:1433-42 pubmed
Wu W, Weigand L, Belkaid Y, Mendez S. Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur J Immunol. 2006;36:3238-47 pubmed
Scalapino K, Tang Q, Bluestone J, Bonyhadi M, Daikh D. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006;177:1451-9 pubmed
Nair R, Kilinc M, Jones S, Egilmez N. Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors. J Immunol. 2006;176:7325-34 pubmed
Baumgart M, Tompkins F, Leng J, Hesse M. Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation. J Immunol. 2006;176:5374-87 pubmed
Anderson C, Mendez S, Sacks D. Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice. J Immunol. 2005;174:2934-41 pubmed
Peng J, Lin J, Kung J, Finkelman F, Wu Hsieh B. The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection. Int Immunol. 2005;17:193-205 pubmed
product information
Product Type :
Antibody
Product Name :
IL-10 Monoclonal Antibody (JES5-16E3), PerCP-Cyanine5.5, eBioscience
Catalog # :
45-7101-80
Quantity :
25 ug
Price :
US 181.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
JES5-16E3
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA